1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Sensitivity and Specificity in 7 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Octanol produced a shift of the current dose-response curve toward lower concentrations of GABA." | 1.29 | Selective effects of alcohols on gamma-aminobutyric acid A receptor subunits expressed in human embryonic kidney cells. ( Carter, DB; Hamilton, BJ; Kurata, Y; Marszalec, W; Narahashi, T, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ohata, K | 1 |
| Chen-Yoshikawa, TF | 1 |
| Menju, T | 1 |
| Miyamoto, E | 1 |
| Tanaka, S | 1 |
| Takahashi, M | 1 |
| Motoyama, H | 1 |
| Hijiya, K | 1 |
| Aoyama, A | 1 |
| Date, H | 1 |
| Ytrebo, LM | 1 |
| Chen, H | 1 |
| Lin, Y | 1 |
| Han, M | 1 |
| Bai, S | 1 |
| Wen, S | 1 |
| Marszalec, W | 1 |
| Kurata, Y | 1 |
| Hamilton, BJ | 1 |
| Carter, DB | 1 |
| Narahashi, T | 1 |
| Pusztai, L | 1 |
| Lewis, CE | 1 |
| McGee, JO | 1 |
| Satoh, M | 1 |
| Hayasaka, M | 1 |
| Horiuchi, K | 1 |
| Takayanagi, I | 1 |
| Nygren, P | 1 |
| Larsson, R | 1 |
7 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Sensitivity and Specificity
| Article | Year |
|---|---|
Protective Effect of Inhaled Rho-Kinase Inhibitor on Lung Ischemia-Reperfusion Injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Inhalation; Animals; Biopsy, Needle; | 2017 |
Vascular dysfunction in septic shock--any ROCKing news?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Disease Models, Animal; Endothelium, | 2009 |
Simultaneous quantitative analysis of fasudil and its active metabolite in human plasma by liquid chromatography electro-spray tandem mass spectrometry.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Chromatography, Liquid; Female; Humans; Male; Molecul | 2010 |
Selective effects of alcohols on gamma-aminobutyric acid A receptor subunits expressed in human embryonic kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Octanol; Base Sequence; Cell Line; Depression, Chem | 1994 |
Growth arrest of the breast cancer cell line, T47D, by TNF alpha; cell cycle specificity and signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltra | 1993 |
Protein kinase C mediates increase of Ca2+ sensitivity for contraction by cholinoceptor partial agonist in ileal longitudinal muscle of guinea pig.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carbachol; Carbazoles; Cholinergic | 1998 |
Modulation of vincristine sensitivity of human kidney tumor cells by pharmacological agents interfering with intracellular signals. No apparent relationship to changes in cytoplasmic Ca2+ or pH.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Calcium; Colforsin; Cytoplasm; Humans | 1990 |