1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Seizures in 7 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Preconditioning by N-methyl-d-aspartate (NMDA) may be promoted in vivo by the administration of a sub-convulsing dose of NMDA, with a neuroprotective effect against seizures and neuronal death induced by the infusion of quinolinic acid (QA) in mice." | 7.77 | NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways. ( Boeck, CR; de Araújo Herculano, B; Martins, WC; Tasca, CI; Vandresen-Filho, S, 2011) |
| "The incidence of convulsion and associated factors were retrospectively analyzed in 23 patients with symptomatic cerebral vasospasm following subarachnoid hemorrhage (SAH) who underwent a total of 31 intra-arterial infusion of fasudil hydrochloride (IAFH) procedures in 49 vessels." | 7.76 | Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage. ( Enomoto, Y; Iwama, T; Yamada, K; Yoshimura, S, 2010) |
| "The authors report a case of convulsion during intra-arterial selective infusion of fasudil hydrochloride (FSD) for treatment of vasospasm following subarachnoid hemorrhage (SAH)." | 7.72 | [A case of convulsion during selective intra-arterial infusion of fasudil hydrochloride for treatment of vasospasm following subarachnoid hemorrhage]. ( Date, I; Nakashimia, H; Ohmoto, T; Ono, S; Sasahara, W; Sugiu, K; Tokunaga, K, 2004) |
| "Preconditioning by N-methyl-d-aspartate (NMDA) may be promoted in vivo by the administration of a sub-convulsing dose of NMDA, with a neuroprotective effect against seizures and neuronal death induced by the infusion of quinolinic acid (QA) in mice." | 3.77 | NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways. ( Boeck, CR; de Araújo Herculano, B; Martins, WC; Tasca, CI; Vandresen-Filho, S, 2011) |
| "The incidence of convulsion and associated factors were retrospectively analyzed in 23 patients with symptomatic cerebral vasospasm following subarachnoid hemorrhage (SAH) who underwent a total of 31 intra-arterial infusion of fasudil hydrochloride (IAFH) procedures in 49 vessels." | 3.76 | Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage. ( Enomoto, Y; Iwama, T; Yamada, K; Yoshimura, S, 2010) |
| " Therefore, we determined the effects of two Rho-kinase inhibitors, Y-27632 and fasudil, on seizures induced by pentylenetetrazole (PTZ) or maximal electroconvulsive shock (MES)." | 3.74 | Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice. ( Büyükafşar, K; Inan, S, 2008) |
| "The authors report a case of convulsion during intra-arterial selective infusion of fasudil hydrochloride (FSD) for treatment of vasospasm following subarachnoid hemorrhage (SAH)." | 3.72 | [A case of convulsion during selective intra-arterial infusion of fasudil hydrochloride for treatment of vasospasm following subarachnoid hemorrhage]. ( Date, I; Nakashimia, H; Ohmoto, T; Ono, S; Sasahara, W; Sugiu, K; Tokunaga, K, 2004) |
| "Fasudil treatment improved cognitive function and central nervous system (CNS) injury, and decreased SC susceptibility in rats." | 1.46 | Effect of fasudil on cognitive function following status convulsion in rats. ( Cheng, L; Han, W; He, R; Jiang, L; Song, X; Tang, X, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Busti, I | 1 |
| Allegra, M | 1 |
| Spalletti, C | 1 |
| Panzi, C | 1 |
| Restani, L | 1 |
| Billuart, P | 1 |
| Caleo, M | 1 |
| He, R | 1 |
| Han, W | 1 |
| Song, X | 1 |
| Tang, X | 1 |
| Cheng, L | 1 |
| Jiang, L | 1 |
| Dang, J | 1 |
| Tian, F | 1 |
| Li, F | 1 |
| Huang, W | 1 |
| Song, M | 1 |
| Ding, D | 1 |
| Huang, X | 1 |
| Inan, S | 1 |
| Büyükafşar, K | 1 |
| Enomoto, Y | 1 |
| Yoshimura, S | 1 |
| Yamada, K | 1 |
| Iwama, T | 1 |
| de Araújo Herculano, B | 1 |
| Vandresen-Filho, S | 1 |
| Martins, WC | 1 |
| Boeck, CR | 1 |
| Tasca, CI | 1 |
| Sasahara, W | 1 |
| Ono, S | 1 |
| Tokunaga, K | 1 |
| Sugiu, K | 1 |
| Nakashimia, H | 1 |
| Date, I | 1 |
| Ohmoto, T | 1 |
7 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Seizures
| Article | Year |
|---|---|
ROCK/PKA Inhibition Rescues Hippocampal Hyperexcitability and GABAergic Neuron Alterations in a Oligophrenin-1 Knock-Out Mouse Model of X-Linked Intellectual Disability.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cyclic AMP-Dependent Protein Kinases; Cytosk | 2020 |
Effect of fasudil on cognitive function following status convulsion in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; CA1 Region, Hippocampal; Cognition; Disease | 2017 |
Roles of Rho guanine nucleotide triphosphatases in hippocampal mossy fiber sprouting in the pentylenetetrazole kindling model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Gene Expression Regulatio | 2014 |
Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Anticonvulsants; Blotting, Western; | 2008 |
Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Aged, 80 and over; Anticonvulsants; Cath | 2010 |
NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Animals; Calcium-Calmodulin-Dependent | 2011 |
[A case of convulsion during selective intra-arterial infusion of fasudil hydrochloride for treatment of vasospasm following subarachnoid hemorrhage].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Humans; Infusions, Intra-Arterial; Male; Middle Aged; | 2004 |