1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Reperfusion Injury in 19 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil, a Rho-kinase inhibitor, is a promising neuroprotectant against ischemic stroke; however, its low bioavailability is an obstacle to be overcome." | 7.83 | Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil. ( Asai, T; Fukuta, T; Kikuchi, T; Koide, H; Namba, M; Oku, N; Sato, A; Shimizu, K; Yanagida, Y, 2016) |
| "The aim of this study is to evaluate the role of Rho-kinase in the pathogenesis of lung injury induced by intestinal ischemia/reperfusion (I/R) and the preconditioning effects of fasudil hydrochloride." | 7.77 | Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion. ( Fan, Z; Hu, XW; Huang, L; Jing, HR; Li, Y; Liu, KX; Tian, XF; Yao, JH, 2011) |
| "Retinal ischemia was induced by increasing the intraocular pressure to 100 mmHg for 60 min." | 5.37 | Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats. ( Gao, D; Song, H, 2011) |
| "Fasudil, a Rho-kinase inhibitor, is a promising neuroprotectant against ischemic stroke; however, its low bioavailability is an obstacle to be overcome." | 3.83 | Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil. ( Asai, T; Fukuta, T; Kikuchi, T; Koide, H; Namba, M; Oku, N; Sato, A; Shimizu, K; Yanagida, Y, 2016) |
| "This study aims to investigate the neuroprotective effect of Rho kinase inhibitor fasudil hydrochloride in ischemia/reperfusion injury N2a neuron." | 3.80 | Fasudil hydrochloride could promote axonal growth through inhibiting the activity of ROCK. ( Liu, DL; Xiao, WD; Yu, AX, 2014) |
| "The aim of this study is to evaluate the role of Rho-kinase in the pathogenesis of lung injury induced by intestinal ischemia/reperfusion (I/R) and the preconditioning effects of fasudil hydrochloride." | 3.77 | Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion. ( Fan, Z; Hu, XW; Huang, L; Jing, HR; Li, Y; Liu, KX; Tian, XF; Yao, JH, 2011) |
| " Administration of fasudil, an inhibitor of Rho-kinase, decreased myocardial infarction size from 59." | 3.75 | Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation. ( Bian, HJ; Ji, XP; Li, XX; Liu, XB; Zhang, J; Zhang, Y, 2009) |
| "Treatment with fasudil (20μM) significantly reduces the expression of GFAP in A172 cells and in spinal cord dorsal column." | 1.40 | Fasudil reduces GFAP expression after hypoxic injury. ( Agrawal, SK; Barnes, R; Kesherwani, V; Tarang, S, 2014) |
| "Retinal ischemia was induced by increasing the intraocular pressure to 100 mmHg for 60 min." | 1.37 | Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats. ( Gao, D; Song, H, 2011) |
| "Brain ischemia was induced by four-vessel occlusion procedure in rats." | 1.32 | Competitive binding of postsynaptic density 95 and Ca2+-calmodulin dependent protein kinase II to N-methyl-D-aspartate receptor subunit 2B in rat brain. ( Guo, J; Meng, FJ; Song, B; Yan, XB; Zhang, GY, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 13 (68.42) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Yanagida, Y | 2 |
| Namba, M | 2 |
| Fukuta, T | 2 |
| Yamamoto, H | 1 |
| Yanagida, M | 1 |
| Honda, M | 1 |
| Oku, N | 2 |
| Asai, T | 2 |
| Ohbuchi, M | 1 |
| Kimura, T | 1 |
| Nishikawa, T | 1 |
| Horiguchi, T | 1 |
| Fukuda, M | 1 |
| Masaki, Y | 1 |
| Wei, XE | 1 |
| Zhang, FY | 1 |
| Wang, K | 1 |
| Zhang, QX | 1 |
| Rong, LQ | 1 |
| Kesherwani, V | 1 |
| Tarang, S | 1 |
| Barnes, R | 1 |
| Agrawal, SK | 1 |
| Xiao, WD | 1 |
| Yu, AX | 1 |
| Liu, DL | 1 |
| Kirchner, C | 1 |
| Lüer, B | 1 |
| Efferz, P | 1 |
| Wohlschlaeger, J | 1 |
| Paul, A | 1 |
| Minor, T | 1 |
| Wang, M | 1 |
| Qi, DS | 1 |
| Zhou, C | 1 |
| Han, D | 1 |
| Li, PP | 1 |
| Zhang, F | 1 |
| Zhou, XY | 1 |
| Han, M | 1 |
| Di, JH | 1 |
| Ye, JS | 1 |
| Yu, HM | 1 |
| Song, YJ | 1 |
| Zhang, GY | 2 |
| Sato, A | 1 |
| Kikuchi, T | 1 |
| Koide, H | 1 |
| Shimizu, K | 1 |
| Ohata, K | 1 |
| Chen-Yoshikawa, TF | 1 |
| Menju, T | 1 |
| Miyamoto, E | 1 |
| Tanaka, S | 1 |
| Takahashi, M | 1 |
| Motoyama, H | 1 |
| Hijiya, K | 1 |
| Aoyama, A | 1 |
| Date, H | 1 |
| Li, Q | 1 |
| Huang, XJ | 1 |
| He, W | 1 |
| Ding, J | 1 |
| Jia, JT | 1 |
| Fu, G | 1 |
| Wang, HX | 1 |
| Guo, LJ | 1 |
| Zhang, J | 1 |
| Li, XX | 1 |
| Bian, HJ | 1 |
| Liu, XB | 1 |
| Ji, XP | 1 |
| Zhang, Y | 1 |
| Li, Y | 1 |
| Yao, JH | 1 |
| Hu, XW | 1 |
| Fan, Z | 1 |
| Huang, L | 1 |
| Jing, HR | 1 |
| Liu, KX | 1 |
| Tian, XF | 1 |
| Song, H | 1 |
| Gao, D | 1 |
| Kuroda, S | 1 |
| Tashiro, H | 1 |
| Igarashi, Y | 1 |
| Tanimoto, Y | 1 |
| Nambu, J | 1 |
| Oshita, A | 1 |
| Kobayashi, T | 2 |
| Amano, H | 1 |
| Tanaka, Y | 1 |
| Ohdan, H | 1 |
| Kentrup, D | 1 |
| Reuter, S | 1 |
| Schnöckel, U | 1 |
| Grabner, A | 1 |
| Edemir, B | 1 |
| Pavenstädt, H | 1 |
| Schober, O | 1 |
| Schäfers, M | 1 |
| Schlatter, E | 1 |
| Büssemaker, E | 1 |
| Wang, QM | 1 |
| Stalker, TJ | 1 |
| Gong, Y | 1 |
| Rikitake, Y | 1 |
| Scalia, R | 1 |
| Liao, JK | 1 |
| Meng, FJ | 1 |
| Guo, J | 1 |
| Song, B | 1 |
| Yan, XB | 1 |
| Yada, T | 1 |
| Shimokawa, H | 1 |
| Hiramatsu, O | 1 |
| Kajita, T | 1 |
| Shigeto, F | 1 |
| Tanaka, E | 1 |
| Shinozaki, Y | 1 |
| Mori, H | 1 |
| Kiyooka, T | 1 |
| Katsura, M | 1 |
| Ohkuma, S | 1 |
| Goto, M | 1 |
| Ogasawara, Y | 1 |
| Kajiya, F | 1 |
| Satoh, S | 1 |
| Utsunomiya, T | 1 |
| Tsurui, K | 1 |
| Ikegaki, I | 1 |
| Sasaki, Y | 1 |
| Asano, T | 1 |
19 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Reperfusion Injury
| Article | Year |
|---|---|
Release rate is a key variable affecting the therapeutic effectiveness of liposomal fasudil for the treatment of cerebral ischemia/reperfusion injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1,2-Dipalmitoylphosphatidylcholine; Ammonium Sulfate; | 2020 |
Neuroprotective Effects of Fasudil, a Rho-Kinase Inhibitor, After Spinal Cord Ischemia and Reperfusion in Rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Intravenous; Animals; Male; Neuroprot | 2018 |
Fasudil hydrochloride protects neurons in rat hippocampal CA1 region through inhibiting GluR6-MLK3-JNKs signal pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; CA1 Region, Hippocampal; Caspase 3; Cytoprot | 2014 |
Fasudil reduces GFAP expression after hypoxic injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Cell Hypoxia; Cell Line, Tumor; | 2014 |
Fasudil hydrochloride could promote axonal growth through inhibiting the activity of ROCK.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Axons; Cell Line, Tumor; Cell Surviv | 2014 |
Ex vivo use of a Rho-kinase inhibitor during renal preservation improves graft function upon reperfusion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Creatinine; Cryopreservation; Glomerular Fil | 2015 |
Ischemic preconditioning protects the brain against injury via inhibiting CaMKII-nNOS signaling pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Brain Ischemia; CA1 Region, Hippo | 2016 |
Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Intravenous; Animals; Brain; Brain Is | 2016 |
Protective Effect of Inhaled Rho-Kinase Inhibitor on Lung Ischemia-Reperfusion Injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Inhalation; Animals; Biopsy, Needle; | 2017 |
Neuroprotective potential of fasudil mesylate in brain ischemia-reperfusion injury of rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Cell Survival; Cer | 2009 |
Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anthracenes; Apoptosis; Apoptosis Inducing F | 2009 |
Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Lung Injury; Animals; Interleukin-6; Intestines | 2011 |
Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; bcl-2-Associated X Protein; Caspase 3; Gene | 2011 |
Rho inhibitor prevents ischemia-reperfusion injury in rat steatotic liver.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Depolymerizing Factors; Animals; Endothelin-1; | 2012 |
Hydroxyfasudil-mediated inhibition of ROCK1 and ROCK2 improves kidney function in rat renal acute ischemia-reperfusion injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Immunohistochemistry; Kid | 2011 |
Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Endothelium, Vascular; Leukocytes; Mice; Mic | 2012 |
Competitive binding of postsynaptic density 95 and Ca2+-calmodulin dependent protein kinase II to N-methyl-D-aspartate receptor subunit 2B in rat brain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding, Competitive; Brain Ischemia; Calciu | 2004 |
Beneficial effect of hydroxyfasudil, a specific Rho-kinase inhibitor, on ischemia/reperfusion injury in canine coronary microcirculation in vivo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Coronary Circulation; Dogs; Female; Intracel | 2005 |
Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Brain Ischemia; Cerebral Arteries; Do | 2001 |