1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Proteinuria in 4 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Proteinuria: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We compared the therapeutic effects of fasudil on the spontaneously hypercholesterolemic (SHC) rat, a model of chronic kidney disease (CKD) with proteinuria, with those of the angiotensin receptor blocker olmesartan (OL) by paying attention to the proteinuria and the macrophage phenotype." | 3.79 | Protective effects of Rho kinase inhibitor fasudil on rats with chronic kidney disease. ( Higashi, K; Kumagai, H; Kushiyama, T; Miura, S; Oda, T; Oshima, N; Sakurai, Y; Takechi, H; Uchida, T; Watanabe, A; Yamamoto, K, 2013) |
| "Fasudil treatment significantly improved survival and decreased proteinuria, particularly when treatment was started at 18 weeks." | 1.38 | Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice. ( Bhagat, G; Biswas, PS; Gupta, S; Pernis, AB; Song, L; Stirzaker, RA, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kushiyama, T | 1 |
| Oda, T | 1 |
| Yamamoto, K | 1 |
| Higashi, K | 1 |
| Watanabe, A | 1 |
| Takechi, H | 1 |
| Uchida, T | 1 |
| Oshima, N | 1 |
| Sakurai, Y | 1 |
| Miura, S | 1 |
| Kumagai, H | 1 |
| Stirzaker, RA | 1 |
| Biswas, PS | 1 |
| Gupta, S | 1 |
| Song, L | 1 |
| Bhagat, G | 1 |
| Pernis, AB | 1 |
| Williams, JM | 1 |
| Johnson, AC | 1 |
| Stelloh, C | 1 |
| Dreisbach, AW | 1 |
| Franceschini, N | 1 |
| Regner, KR | 1 |
| Townsend, RR | 1 |
| Roman, RJ | 1 |
| Garrett, MR | 1 |
| Kanda, T | 1 |
| Wakino, S | 1 |
| Hayashi, K | 1 |
| Homma, K | 1 |
| Ozawa, Y | 1 |
| Saruta, T | 1 |
4 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Proteinuria
| Article | Year |
|---|---|
Protective effects of Rho kinase inhibitor fasudil on rats with chronic kidney disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Angiotensin II Type 1 Receptor Blockers; Anim | 2013 |
Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Oral; Animals; Antigen-Antibody Compl | 2012 |
Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Congenic; Blood Pressure; Blotting, | 2012 |
Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Pressure; Cell Cycle Proteins; Cell Di | 2003 |