1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Pregnancy in 38 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to evaluate the effects of fasudil on insulin resistance (IR) in HTR-8/SVneo cells." | 8.02 | Fasudil alleviated insulin resistance through promotion of proliferation, attenuation of cell apoptosis and inflammation and regulation of RhoA/Rho kinase/insulin/nuclear factor-κB signalling pathway in HTR-8/SVneo cells. ( Bai, Y; Du, Q; Du, R; Li, L; Li, P; Tang, L; Zhang, L; Zhang, W, 2021) |
| "The aim of this study was to evaluate the effects of fasudil on insulin resistance (IR) in HTR-8/SVneo cells." | 4.02 | Fasudil alleviated insulin resistance through promotion of proliferation, attenuation of cell apoptosis and inflammation and regulation of RhoA/Rho kinase/insulin/nuclear factor-κB signalling pathway in HTR-8/SVneo cells. ( Bai, Y; Du, Q; Du, R; Li, L; Li, P; Tang, L; Zhang, L; Zhang, W, 2021) |
| "To compare the effects of two serine-threonine protein kinase inhibitors in a mouse lens culture system previously designed to investigate cortical cataracts caused by L-buthionine sulfoximine (BSO), inhibitor of GSH biosynthesis." | 3.72 | Induction of cortical cataracts in cultured mouse lenses with H-89, an inhibitor of protein kinase A. ( Banerjee, U; Calvin, HI; Fu, SC; Guo, L; Li, W; Wu, K, 2003) |
| "Pretreatment with fasudil, a Rho kinase inhibitor, blunted the effects of 5-HT infusion." | 1.37 | Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus. ( Abman, SH; Delaney, C; Gien, J; Grover, TR; Roe, G, 2011) |
| "Fasudil was injected peritoneally into the neonate, and the ductus was studied 30 min after injection and 60 min after birth." | 1.35 | In vivo dilatation of the ductus arteriosus by Rho kinase inhibition in the rat. ( Momma, K; Nakanishi, T; Sun, F; Toyoshima, K, 2009) |
| "A23187, a Ca2+ ionophore, induced situs inversus; nifedipine, a L-type Ca2+ channel blocker, partially blocked phenylephrine-induced situs inversus." | 1.29 | Receptor subtype and intracellular signal transduction pathway associated with situs inversus induced by alpha 1 adrenergic stimulation in rat embryos. ( Baden, JM; Fujinaga, M; Hoffman, BB, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (7.89) | 18.7374 |
| 1990's | 22 (57.89) | 18.2507 |
| 2000's | 5 (13.16) | 29.6817 |
| 2010's | 6 (15.79) | 24.3611 |
| 2020's | 2 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Ostendorf, F | 1 |
| Metzdorf, J | 1 |
| Gold, R | 1 |
| Haghikia, A | 1 |
| Tönges, L | 1 |
| Bai, Y | 1 |
| Du, Q | 1 |
| Zhang, L | 2 |
| Li, L | 2 |
| Tang, L | 1 |
| Zhang, W | 1 |
| Du, R | 1 |
| Li, P | 1 |
| Domokos, D | 1 |
| Ducza, E | 1 |
| Gáspár, R | 1 |
| Salman, S | 1 |
| Holloway, AC | 1 |
| Nurse, CA | 1 |
| Ergul, M | 1 |
| Turgut, NH | 1 |
| Sarac, B | 1 |
| Altun, A | 1 |
| Yildirim, Ş | 1 |
| Bagcivan, I | 1 |
| Tourneux, P | 1 |
| Chester, M | 1 |
| Grover, T | 1 |
| Abman, SH | 3 |
| Momma, K | 1 |
| Toyoshima, K | 1 |
| Sun, F | 1 |
| Nakanishi, T | 1 |
| Delaney, C | 1 |
| Gien, J | 1 |
| Grover, TR | 2 |
| Roe, G | 2 |
| Butruille, L | 1 |
| Mayeur, S | 1 |
| Duparc, T | 1 |
| Knauf, C | 1 |
| Moitrot, E | 1 |
| Fajardy, I | 1 |
| Valet, P | 1 |
| Storme, L | 1 |
| Deruelle, P | 1 |
| Lesage, J | 1 |
| Ojeda, NB | 1 |
| Royals, TP | 1 |
| Alexander, BT | 1 |
| Calvin, HI | 1 |
| Wu, K | 1 |
| Li, W | 1 |
| Guo, L | 1 |
| Banerjee, U | 1 |
| Fu, SC | 1 |
| Parker, TA | 1 |
| Cole, OF | 1 |
| Seki, H | 1 |
| Sullivan, MH | 1 |
| Elder, MG | 1 |
| Cabell, L | 1 |
| Audesirk, G | 1 |
| Nilius, B | 1 |
| Schwartz, G | 1 |
| Oike, M | 1 |
| Droogmans, G | 1 |
| Okatani, Y | 1 |
| Taniguchi, K | 1 |
| Sagara, Y | 1 |
| Nabekura, J | 1 |
| Kawamoto, I | 1 |
| Akaike, N | 1 |
| Fujinaga, M | 1 |
| Hoffman, BB | 1 |
| Baden, JM | 1 |
| Mitchell, MD | 2 |
| LaMarche, S | 1 |
| Adamson, S | 1 |
| Coulam, C | 1 |
| Silver, RM | 1 |
| Edwin, SS | 1 |
| Pollard, JK | 1 |
| Hinko, A | 1 |
| Soloff, MS | 1 |
| Bayat-Sarmadi, M | 1 |
| Houdebine, LM | 1 |
| Morimoto, T | 1 |
| Devora, GA | 1 |
| Mibe, M | 1 |
| Casey, ML | 1 |
| MacDonald, PC | 1 |
| Sjöholm, A | 1 |
| Yamamoto, T | 1 |
| Chapman, BM | 1 |
| Soares, MJ | 1 |
| Sil, P | 1 |
| Kandaswamy, V | 1 |
| Sen, S | 1 |
| Akopov, SE | 1 |
| Pearce, WJ | 1 |
| Monaghan, AS | 1 |
| Baines, DL | 1 |
| Muimo, R | 1 |
| Olver, RE | 1 |
| Fujisawa, K | 1 |
| Nasu, K | 1 |
| Arima, K | 1 |
| Sugano, T | 1 |
| Narahara, H | 1 |
| Miyakawa, I | 1 |
| Bhat, NR | 1 |
| Hauser, KF | 1 |
| Kindy, MS | 1 |
| Rajabi, MR | 1 |
| Solomon, S | 1 |
| Poole, AR | 1 |
| Tamanini, A | 1 |
| Berton, G | 1 |
| Cabrini, G | 1 |
| Moore, JJ | 1 |
| Moore, RM | 1 |
| Vander Kooy, D | 1 |
| Tanigawa, K | 1 |
| Tsuchiyama, S | 1 |
| Kato, Y | 1 |
| Johnson, SE | 1 |
| Baglioni, C | 1 |
| Magnússon, MK | 1 |
| Halldórsson, H | 1 |
| Kjeld, M | 1 |
| Thorgeirsson, G | 1 |
| Poueymirou, WT | 1 |
| Schultz, RM | 2 |
| Manejwala, FM | 1 |
38 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Pregnancy
| Article | Year |
|---|---|
Propionic Acid and Fasudil as Treatment Against Rotenone Toxicity in an In Vitro Model of Parkinson's Disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Cell Survival; Cells, Cul | 2020 |
Fasudil alleviated insulin resistance through promotion of proliferation, attenuation of cell apoptosis and inflammation and regulation of RhoA/Rho kinase/insulin/nuclear factor-κB signalling pathway in HTR-8/SVneo cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Caspase 3; Cell Survival; Cells, Cultured; | 2021 |
RhoA and Rho-kinase inhibitors modulate cervical resistance: The possible role of RhoA/Rho-kinase signalling pathway in cervical ripening and contractility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cervical Ripening; Cervix Uteri; Fem | 2019 |
Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Cortex; Adrenal Medulla; Analgesics, Opioid; | 2014 |
Investigating the effects of the Rho-kinase enzyme inhibitors AS1892802 and fasudil hydrochloride on the contractions of isolated pregnant rat myometrium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Female; Myometrium; Phenylurea Compounds; Pr | 2016 |
Fasudil inhibits the myogenic response in the fetal pulmonary circulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Pressure; Cardiovascular Agents; Const | 2008 |
In vivo dilatation of the ductus arteriosus by Rho kinase inhibition in the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Cardiovascular Surgical Pr | 2009 |
Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Dose-Response Relationship, Drug; Female; Fe | 2011 |
Prenatal fasudil exposure alleviates fetal growth but programs hyperphagia and overweight in the adult male rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Animals; Female; Fetal Development; Feta | 2012 |
Sex differences in the enhanced responsiveness to acute angiotensin II in growth-restricted rats: role of fasudil, a Rho kinase inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Blood Pressure; Castration; | 2013 |
Induction of cortical cataracts in cultured mouse lenses with H-89, an inhibitor of protein kinase A.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Crystallin A Chain; Animals; Animals, Newborn; | 2003 |
Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Dose-Response Relationship, Drug; En | 2006 |
Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Decidua; Dinoprostone; Do | 1995 |
Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein kinase, and Ca(2+)-calmodulin-dependent protein kinase on neurite development in cultured rat hippocampal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Calcium-Calmodulin-Dependent Protein | 1993 |
Histamine-activated, non-selective cation currents and Ca2+ transients in endothelial cells from human umbilical vein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium Channels; Cations, Divalent; Electrophysiolog | 1993 |
Amplifying effect of endothelin-1 on serotonin-induced vasoconstriction of human umbilical artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Calcium Chloride; Dose-Response | 1995 |
Developmental change in voltage dependency of NMDA receptor-mediated response in nucleus tractus solitarii neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Electrophysiology; Female; | 1994 |
Receptor subtype and intracellular signal transduction pathway associated with situs inversus induced by alpha 1 adrenergic stimulation in rat embryos.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Calcium-Calmodulin-Depe | 1994 |
Regulation of intrauterine prostaglandin biosynthesis: interactions between protein kinase C and interleukin 1 beta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amnion; Chorion; Decidua; Dinoprostone; Fe | 1994 |
Tumor necrosis factor alpha stimulates amnion prostaglandin biosynthesis primarily via an action on fatty acid cyclooxygenase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amnion; Arachidonic Acid; Aspirin; Cells, | 1993 |
Up-regulation of oxytocin receptors in rabbit amnion by adenosine 3',5'-monophosphate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amnion; Animals; Bucladesine; Cholera Toxin; Colforsi | 1993 |
Effect of various protein kinase inhibitors on the induction of milk protein gene expression by prolactin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine; Alkaloids; Animals; Cells, Cultured; Epithel | 1993 |
Parathyroid hormone-related protein and human myometrial cells: action and regulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Chorionic Gonadotropin; Colfors | 1997 |
Glucose stimulates islet beta-cell mitogenesis through GTP-binding proteins and by protein kinase C-dependent mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atrial Natriuretic Factor; Calcium Channel B | 1997 |
Protein kinase C dependent and independent mechanisms controlling rat trophoblast cell DNA synthesis and differentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Blotting, N | 1997 |
Increased protein kinase C activity in myotrophin-induced myocyte growth.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Animals; Antisense Elements (Genetics); | 1998 |
Regulation of Ca2+ sensitization by PKC and rho proteins in ovine cerebral arteries: effects of artery size and age.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Calcium; Cerebral Arteries; Enzyme Ac | 1998 |
Inwardly rectifying K+ currents in fetal alveolar type II cells: regulation by protein kinase A and protein phosphatases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Colforsin; Cyclic AMP-Dependent | 1999 |
Production of interleukin (IL)-6 and IL-8 by a choriocarcinoma cell line, BeWo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Blotting, Northern; Choriocarcinoma; Dexametha | 2000 |
Cell proliferation and protooncogene induction in oligodendroglial progenitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Autoradiography; Blotting, Northern; Cell Di | 1992 |
Activation of protein kinase C stimulates collagenase production by cultured cells of the cervix of the pregnant guinea pig.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Cervix Uteri; Collagenases; | 1992 |
Adenosine 3':5'-monophosphate-dependent protein kinase from human placenta: characterization of the catalytic subunit.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Binding Sites; Female; Humans | 1991 |
Protein kinase-C activation is required for oxytocin-induced prostaglandin production in human amnion cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amnion; Calcium; Cells, Cultured; Cyclohex | 1991 |
Differential sensitivity of pancreatic beta-cells to phorbol ester TPA and C-kinase inhibitor H-7 in nonpregnant and pregnant rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Female; Insulin; Insulin Secretion; Islets o | 1990 |
Positive and negative regulation of a tumor necrosis factor response in melanoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; DNA Probes; Female; Humans; Isoqu | 1990 |
Endothelial inositol phosphate generation and prostacyclin production in response to G-protein activation by AlF4-.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 6-Ketoprostaglandin F1 alpha; Aluminum; Aluminum Comp | 1989 |
Regulation of mouse preimplantation development: inhibition of synthesis of proteins in the two-cell embryo that require transcription by inhibitors of cAMP-dependent protein kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amanitins; Animals; Blastocyst; Carrier Proteins; Cyc | 1989 |
Blastocoel expansion in the preimplantation mouse embryo: stimulation of sodium uptake by cAMP and possible involvement of cAMP-dependent protein kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biological Transport; Blastocyst; Cyclic AMP | 1989 |