1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Ovarian Neoplasms in 6 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The poor prognosis of advanced ovarian cancer comes from increased invasiveness of human ovarian cancer cells." | 1.35 | Fasudil inhibits lysophosphatidic acid-induced invasiveness of human ovarian cancer cells. ( Hashimoto, K; Kawase, C; Kimura, T; Mabuchi, S; Morishige, K; Ogata, S; Ooyagi, C; Sakata, M; Sawada, K, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ogata, S | 1 |
| Morishige, K | 1 |
| Sawada, K | 1 |
| Hashimoto, K | 1 |
| Mabuchi, S | 1 |
| Kawase, C | 1 |
| Ooyagi, C | 1 |
| Sakata, M | 1 |
| Kimura, T | 1 |
| Ohta, T | 1 |
| Takahashi, T | 1 |
| Shibuya, T | 1 |
| Amita, M | 1 |
| Henmi, N | 1 |
| Takahashi, K | 1 |
| Kurachi, H | 1 |
| Obata, NH | 1 |
| Okazaki, K | 1 |
| Maeda, O | 1 |
| Kikkawa, F | 1 |
| Tomoda, Y | 1 |
| Hidaka, H | 1 |
| Powell, CB | 1 |
| Manning, K | 1 |
| Collins, JL | 1 |
| Gimond, C | 1 |
| Mercier, I | 1 |
| Weber, I | 1 |
| Aumailley, M | 1 |
| Hayakawa, A | 1 |
| Yokoyama, I | 1 |
| Tajiri, H | 1 |
| Okamoto, T | 1 |
| Nakashima, I | 1 |
6 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Ovarian Neoplasms
| Article | Year |
|---|---|
Fasudil inhibits lysophosphatidic acid-induced invasiveness of human ovarian cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antineoplastic Agents; Carcinoma; Cell Movem | 2009 |
Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through the blockage of hypoxia-inducible factor-1α in human ovarian cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line, Tumor; Cisplatin; Drug Synergism; Female; | 2012 |
Effect of KN-62, Ca2+/calmodulin-dependent protein kinase II inhibitor, on adriamycin resistance of human ovarian cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ATP Binding Cassette Transporter, Subfamily B, Member | 1995 |
Interferon-alpha (IFN alpha) induces a cytolytic mechanism in ovarian carcinoma cells through a protein kinase C-dependent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Cell Survival; Dacti | 1993 |
Adhesion complexes formed by OVCAR-4 cells on laminin 1 differ from those observed on fibronectin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Cell Adhesion; Enzyme Inh | 1996 |
Protein kinase C-dependent anti-apoptotic mechanism that is associated with high sensitivity to anti-Fas antibody in ovarian cancer cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies; Apoptosis; Calcimycin; Cell Division; Cer | 1999 |