1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Osteogenic Sarcoma in 10 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment of human MG-63 osteosarcoma cells with human recombinant transforming growth factor beta 1 (TGF-beta 1) was found to inhibit cell proliferation." | 7.69 | Effects of transforming growth factor beta 1 on the regulation of osteocalcin synthesis in human MG-63 osteosarcoma cells. ( Jääskeläinen, T; Mäenpää, PH; Pirskanen, A, 1994) |
| "Treatment of human MG-63 osteosarcoma cells with human recombinant transforming growth factor beta 1 (TGF-beta 1) was found to inhibit cell proliferation." | 3.69 | Effects of transforming growth factor beta 1 on the regulation of osteocalcin synthesis in human MG-63 osteosarcoma cells. ( Jääskeläinen, T; Mäenpää, PH; Pirskanen, A, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 7 (70.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xia, Y | 1 |
| Cai, X | 1 |
| Fan, J | 1 |
| Zhang, L | 1 |
| Li, Z | 1 |
| Ren, J | 1 |
| Wu, G | 1 |
| Zhu, F | 1 |
| Adachi, S | 1 |
| Kubota, M | 1 |
| Lin, YW | 1 |
| Okuda, A | 1 |
| Matsubara, K | 1 |
| Wakazono, Y | 1 |
| Hirota, H | 1 |
| Kuwakado, K | 1 |
| Akiyama, Y | 1 |
| Pirskanen, A | 1 |
| Jääskeläinen, T | 1 |
| Mäenpää, PH | 1 |
| Sugimoto, T | 3 |
| Kano, J | 1 |
| Yamaguchi, T | 3 |
| Fukase, M | 4 |
| Chihara, K | 2 |
| Arao, M | 1 |
| Migliaccio, S | 1 |
| Wetsel, WC | 1 |
| Fox, WM | 1 |
| Washburn, TF | 1 |
| Korach, KS | 1 |
| Babich, M | 1 |
| Foti, LR | 1 |
| Mathias, KL | 1 |
| Broberg, A | 1 |
| Nissinen, L | 1 |
| Potila, M | 1 |
| Heino, J | 1 |
| Ikeda, K | 1 |
| Fujita, T | 2 |
| Baba, H | 1 |
| Kinoshita, Y | 1 |
| Fujimi, T | 1 |
1 trial available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Osteogenic Sarcoma
| Article | Year |
|---|---|
In vivo administration of granulocyte colony-stimulating factor promotes neutrophil survival in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adolescent; Burkitt Lymphoma; Cell Survival; Child; C | 1994 |
9 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Osteogenic Sarcoma
| Article | Year |
|---|---|
RhoA/ROCK pathway inhibition by fasudil suppresses the vasculogenic mimicry of U2OS osteosarcoma cells in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell | 2017 |
Effects of transforming growth factor beta 1 on the regulation of osteocalcin synthesis in human MG-63 osteosarcoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Base Sequence; Bone Neoplasms; Calcitriol; Cell Divis | 1994 |
Role of calcium/protein kinase C in the regulation of DNA synthesis by parathyroid hormone-related peptide in osteoblastic osteosarcoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cyclic AMP; DNA; Enzyme Activation; Humans; | 1993 |
Protein kinase C is crucial for the stimulation of sodium-dependent phosphate transport by parathyroid hormone-related peptide in osteoblast-like cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Biological Transport; Bon | 1994 |
Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaline Phosphatase; Alkaloids; Animals; Blotting, N | 1993 |
Protein kinase C modulator effects on parathyroid hormone-induced intracellular calcium and morphologic changes in UMR 106-H5 osteoblastic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Calcium; Chelating Agents | 1997 |
Three-dimensional collagen regulates collagen gene expression by a mechanism that requires serine/threonine kinases and is independent of mechanical contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, CD; Bone Neoplasms; Cell Adhesion; Collagen | 2001 |
Protein kinase C is involved in PTH-induced homologous desensitization by directly affecting PTH receptor in the osteoblastic osteosarcoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cyclic AMP; GTP-Binding Proteins; Isoquinoli | 1991 |
Possible involvement of protein kinase C in parathyroid hormone degradation by osteoblast-like rat osteosarcoma cell line UMR106.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diglycerides; Isoquinolines; Osteoblasts; Os | 1987 |