1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Ocular Hypertension in 4 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Ocular Hypertension: A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In addition, in the rabbit ocular hypertension model, the topical administration of H-1152P (28 mM) significantly lowered IOPs starting at 30 minutes and lasting up to 300 minutes after water loading." | 1.35 | The effect of the H-1152P, a potent Rho-associated coiled coil-formed protein kinase inhibitor, in rabbit normal and ocular hypertensive eyes. ( Fukunaga, T; Hidaka, H; Ikesugi, K; Nishio, M; Sugimoto, M; Sumi, K; Uji, Y, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, M | 1 |
| Chen, X | 1 |
| Wang, N | 1 |
| Cai, S | 1 |
| Li, N | 1 |
| Qiu, J | 1 |
| Brandt, CR | 1 |
| Kaufman, PL | 2 |
| Liu, X | 1 |
| Fukunaga, T | 2 |
| Ikesugi, K | 2 |
| Nishio, M | 2 |
| Sugimoto, M | 2 |
| Sasoh, M | 1 |
| Hidaka, H | 2 |
| Uji, Y | 2 |
| Sumi, K | 1 |
| Gabelt, BT | 1 |
| Hennes, EA | 1 |
| Seeman, JL | 1 |
| Tian, B | 1 |
4 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Ocular Hypertension
| Article | Year |
|---|---|
H-1152 effects on intraocular pressure and trabecular meshwork morphology of rat eyes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Cells, Cultured; Eye; Humans; Int | 2008 |
The effect of the Rho-associated protein kinase inhibitor, HA-1077, in the rabbit ocular hypertension model induced by water loading.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Topical; Animals; Disease Models, Ani | 2009 |
The effect of the H-1152P, a potent Rho-associated coiled coil-formed protein kinase inhibitor, in rabbit normal and ocular hypertensive eyes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Topical; Animals; Conjunctiva; Dose-R | 2009 |
H-7 effect on outflow facility after trabecular obstruction following long-term echothiophate treatment in monkeys.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Accommodation, Ocular; Animals; Aqueous Humor; Cholin | 2004 |