1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Neurodegenerative Diseases in 2 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil is a Rho kinase inhibitor and has been reported to have neuroprotective effects." | 1.39 | Rho kinase inhibitor fasudil protects against β-amyloid-induced hippocampal neurodegeneration in rats. ( Chen, X; Gao, W; Song, Y; Wang, LY; Zhu, MJ, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Killick, R | 1 |
| Elliott, C | 1 |
| Ribe, E | 1 |
| Broadstock, M | 1 |
| Ballard, C | 1 |
| Aarsland, D | 1 |
| Williams, G | 1 |
| Song, Y | 1 |
| Chen, X | 1 |
| Wang, LY | 1 |
| Gao, W | 1 |
| Zhu, MJ | 1 |
1 review available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Neurodegenerative Diseases
| Article | Year |
|---|---|
Neurodegenerative Disease Associated Pathways in the Brains of Triple Transgenic Alzheimer's Model Mice Are Reversed Following Two Weeks of Peripheral Administration of Fasudil.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alzheimer Disease; Animals; Brain; Mice; Mice, Transg | 2023 |
1 other study available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Neurodegenerative Diseases
| Article | Year |
|---|---|
Rho kinase inhibitor fasudil protects against β-amyloid-induced hippocampal neurodegeneration in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amyloid beta-Peptides; Animals; Hippocampus; Male; Ne | 2013 |