1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Neuroblastoma in 48 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here we show that in mouse cholinergic NS-20Y neuroblastoma cells cultured in the presence of either okadaic acid (serine/threonine phosphatases 1 and 2A inhibitor) or KN-62 (CaM kinase inhibitor) ChAT activity and mRNA either increased or decreased as a function of the drug concentration, respectively." | 7.71 | Modulation of choline acetyltransferase synthesis by okadaic acid, a phosphatase inhibitor, and KN-62, a CaM kinase inhibitor, in NS-20Y neuroblastoma. ( Bontron, S; Eder-Colli, L; Pahud, G, 2001) |
| "Lithium, carbamazepine and sodium valproate are mood stabilizers used in the treatment of bipolar disorder, and although their mechanisms of action remain unknown, signal transduction systems and the associated modulation of gene expression may constitute significant actions." | 7.70 | Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells. ( Jope, RS; Pacheco, MA, 1999) |
| "Apoptotic cell death is induced in SH-SY5Y neuroblastoma cells following exposure to the protein kinase inhibitors staurosporine (100 nM) and 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine: H-7 (100 microM)." | 7.70 | Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway. ( Ferrer, I; López, E, 2000) |
| "Our previous studies have demonstrated that the protein kinase inhibitor H-7 promotes neurite outgrowth from mouse neuroblastoma N18TG2 cells as well as from primary cerebellar cells, and also that the neurites induced by H-7 were more tolerant of colchicine (COL) than those induced by dibutyryl cAMP (dB-cAMP)." | 7.68 | Neurite outgrowth from N18TG2 neuroblastoma induced by H-7, a protein kinase inhibitor, in the presence of colchicine. ( Ono, K; Tokunaga, A; Tsuda, M, 1993) |
| "SH-SY-5Y human neuroblastoma cells rapidly elaborated an extensive network of neuritic processes following treatment with staurosporine, an inhibitor of protein kinase C." | 7.68 | Staurosporine-induced morphological differentiation of human neuroblastoma cells. ( Beermann, ML; Shea, TB, 1991) |
| "The effects of phorbol 12-myristate 13-acetate (PMA) on carbamylcholine (CBC)-induced [3H]cyclic GMP formation in mouse neuroblastoma cells (clone N1E-115) were studied." | 7.67 | Phorbol ester-induced inhibition of cyclic GMP formation mediated by muscarinic receptors in murine neuroblastoma cells. ( el-Fakahany, EE; Lai, WS, 1987) |
| " Here we show that in mouse cholinergic NS-20Y neuroblastoma cells cultured in the presence of either okadaic acid (serine/threonine phosphatases 1 and 2A inhibitor) or KN-62 (CaM kinase inhibitor) ChAT activity and mRNA either increased or decreased as a function of the drug concentration, respectively." | 3.71 | Modulation of choline acetyltransferase synthesis by okadaic acid, a phosphatase inhibitor, and KN-62, a CaM kinase inhibitor, in NS-20Y neuroblastoma. ( Bontron, S; Eder-Colli, L; Pahud, G, 2001) |
| "Lithium, carbamazepine and sodium valproate are mood stabilizers used in the treatment of bipolar disorder, and although their mechanisms of action remain unknown, signal transduction systems and the associated modulation of gene expression may constitute significant actions." | 3.70 | Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells. ( Jope, RS; Pacheco, MA, 1999) |
| "Apoptotic cell death is induced in SH-SY5Y neuroblastoma cells following exposure to the protein kinase inhibitors staurosporine (100 nM) and 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine: H-7 (100 microM)." | 3.70 | Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway. ( Ferrer, I; López, E, 2000) |
| "Pretreatment of human neuroblastoma cells with an inhibitor of protein kinase C (PKC), staurosporine or H-7, prior to the addition of human alpha interferon (HuIFN-alpha), recombinant HuIFN-alpha, or recombinant HuIFN-beta blocked the inhibitory effect of these IFNs on the release of infectious herpes simplex virus type 1 from treated cells." | 3.69 | Effect of protein kinase C inhibitors on the antiviral activity of human alpha interferon in herpes simplex virus-infected human neuroblastoma cells. ( Burns, P; Chatterjee, S; Koga, J, 1995) |
| "Lithium has a biphasic effect of the agonist-dependent accumulation of Ins(1,4,5)P3 in human neuroblastoma SH-SY5Y cells." | 3.69 | Phosphoinositide signalling in human neuroblastoma cells: biphasic effect of Li+ on the level of the inositolphosphate second messengers. ( Artemenko, IP; Hokin, LE; Los, GV, 1996) |
| "Protein phosphorylation and subsequent dephosphorylation was studied in digitonin-permeabilized neuroblastoma SH-SY5Y cells by measuring the incorporation of [32P]phosphate into myelin basic protein (MBP)." | 3.68 | An okadaic acid-sensitive protein phosphatase counteracts protein kinase C-induced phosphorylation in SH-SY5Y cells. ( Alling, C; Larsson, C; Simonsson, P, 1993) |
| "Our previous studies have demonstrated that the protein kinase inhibitor H-7 promotes neurite outgrowth from mouse neuroblastoma N18TG2 cells as well as from primary cerebellar cells, and also that the neurites induced by H-7 were more tolerant of colchicine (COL) than those induced by dibutyryl cAMP (dB-cAMP)." | 3.68 | Neurite outgrowth from N18TG2 neuroblastoma induced by H-7, a protein kinase inhibitor, in the presence of colchicine. ( Ono, K; Tokunaga, A; Tsuda, M, 1993) |
| "SH-SY-5Y human neuroblastoma cells rapidly elaborated an extensive network of neuritic processes following treatment with staurosporine, an inhibitor of protein kinase C." | 3.68 | Staurosporine-induced morphological differentiation of human neuroblastoma cells. ( Beermann, ML; Shea, TB, 1991) |
| "Preincubation with receptor agonists or phorbol esters desensitized muscarinic-receptor-mediated [3H]cyclic GMP responses in mouse neuroblastoma N1E-115 cells." | 3.68 | Protein kinase C is involved in desensitization of muscarinic receptors induced by phorbol esters but not by receptor agonists. ( el-Fakahany, EE; Lai, WS; Rogers, TB, 1990) |
| "The effects of phorbol 12-myristate 13-acetate (PMA) on carbamylcholine (CBC)-induced [3H]cyclic GMP formation in mouse neuroblastoma cells (clone N1E-115) were studied." | 3.67 | Phorbol ester-induced inhibition of cyclic GMP formation mediated by muscarinic receptors in murine neuroblastoma cells. ( el-Fakahany, EE; Lai, WS, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (14.58) | 18.7374 |
| 1990's | 36 (75.00) | 18.2507 |
| 2000's | 4 (8.33) | 29.6817 |
| 2010's | 1 (2.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iglesias, RM | 1 |
| Spray, DC | 1 |
| De Sarno, P | 1 |
| Shestopal, SA | 1 |
| Zmijewska, AA | 1 |
| Jope, RS | 3 |
| Kamata, Y | 1 |
| Hattori, Y | 1 |
| Adachi, S | 1 |
| Kubota, M | 1 |
| Lin, YW | 1 |
| Okuda, A | 1 |
| Matsubara, K | 1 |
| Wakazono, Y | 1 |
| Hirota, H | 1 |
| Kuwakado, K | 1 |
| Akiyama, Y | 1 |
| Schwarzschild, MA | 1 |
| Dauer, WT | 1 |
| Lewis, SE | 1 |
| Hamill, LK | 1 |
| Fink, JS | 1 |
| Hyman, SE | 1 |
| Miñana, MD | 7 |
| Cabedo, H | 2 |
| Felipo, V | 7 |
| Grisolía, S | 7 |
| Inukai, T | 1 |
| Chik, CL | 1 |
| Ho, AK | 1 |
| Larsson, C | 2 |
| Alling, C | 1 |
| Simonsson, P | 2 |
| Chatterjee, S | 1 |
| Burns, P | 1 |
| Koga, J | 1 |
| Zhang, L | 1 |
| Bouillon, M | 2 |
| Audette, M | 2 |
| Uemura, K | 1 |
| Hara, A | 1 |
| Taketomi, T | 1 |
| Ono, K | 3 |
| Tokunaga, A | 2 |
| Tsuda, M | 4 |
| Puymirat, J | 1 |
| Etongue-Mayer, P | 1 |
| Dussault, JH | 1 |
| Los, GV | 1 |
| Artemenko, IP | 1 |
| Hokin, LE | 1 |
| Ronca, F | 2 |
| Chan, SL | 1 |
| Yu, VC | 2 |
| Puhl, HL | 1 |
| Raman, PS | 1 |
| Williams, CL | 1 |
| Aronstam, RS | 1 |
| Nomura, T | 2 |
| Kumatoriya, K | 1 |
| Yoshimura, Y | 2 |
| Yamauchi, T | 2 |
| Fujii, M | 1 |
| Sugiura, H | 1 |
| Lu, R | 1 |
| Song, L | 1 |
| Yee, KS | 1 |
| Pacheco, MA | 1 |
| Pahud, G | 1 |
| Bontron, S | 1 |
| Eder-Colli, L | 1 |
| López, E | 1 |
| Ferrer, I | 1 |
| Suidan, HS | 1 |
| Stone, SR | 1 |
| Hemmings, BA | 1 |
| Monard, D | 1 |
| Considine, RV | 1 |
| Sherwin, JR | 1 |
| Simpson, LL | 1 |
| Shea, TB | 2 |
| Beermann, ML | 2 |
| Leli, U | 1 |
| Nixon, RA | 1 |
| Cara, A | 1 |
| Pecorara, M | 1 |
| Cornaglia-Ferraris, P | 1 |
| Tsuneishi, S | 1 |
| Romero, FJ | 1 |
| Llopis, J | 1 |
| Romá, J | 1 |
| Katayama, N | 2 |
| Yamagata, Y | 2 |
| Lai, WS | 2 |
| Rogers, TB | 1 |
| el-Fakahany, EE | 2 |
| Mangels, LA | 1 |
| Gnegy, ME | 1 |
| Parodi, MT | 1 |
| Varesio, L | 1 |
| Tonini, GP | 1 |
| Heikkilä, JE | 2 |
| Akerlind, G | 1 |
| Akerman, KE | 2 |
| Kikuchi, K | 2 |
| Tsuchiya, T | 2 |
| Sekikawa, M | 1 |
| Imoto, M | 1 |
| Jalava, AM | 1 |
| Liscovitch, M | 1 |
| Slack, B | 1 |
| Blusztajn, JK | 1 |
| Wurtman, RJ | 1 |
1 trial available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Neuroblastoma
| Article | Year |
|---|---|
In vivo administration of granulocyte colony-stimulating factor promotes neutrophil survival in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adolescent; Burkitt Lymphoma; Cell Survival; Child; C | 1994 |
47 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Neuroblastoma
| Article | Year |
|---|---|
Pannexin1-mediated ATP release provides signal transmission between Neuro2A cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphatases; Adenosine Triphosphate; An | 2012 |
Anti-apoptotic effects of muscarinic receptor activation are mediated by Rho kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Dose-Response Relationship, Drug; Humans; | 2005 |
Neural differentiation of human neuroblastoma GOTO cells via a Rho-Rho kinase-phosphorylation signal transduction and continuous observation of a single GOTO cell during differentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Botulinum Toxins; Cell Diffe | 2007 |
Leukemia inhibitory factor and ciliary neurotrophic factor increase activated Ras in a neuroblastoma cell line and in sympathetic neuron cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Animals, Newborn; Blotting, Weste | 1994 |
Protein kinase C inhibitors, H7 and calphostin C, inhibit induction of DNA synthesis by cytosolic extracts of exponentially growing neuroblastoma cells in isolated nuclei.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Cycle; Cell Division; Cricetinae; Cytos | 1994 |
Vasoactive intestinal polypeptide stimulates cyclic AMP production in mouse N1E-115 neuroblastoma cells: modulation by a protein kinase C activator and ionomycin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Animals; Calcium; Carcin | 1994 |
An okadaic acid-sensitive protein phosphatase counteracts protein kinase C-induced phosphorylation in SH-SY5Y cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Calcium; Cell Membran | 1993 |
Effect of protein kinase C inhibitors on the antiviral activity of human alpha interferon in herpes simplex virus-infected human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Herpesvirus 1, Human; Humans; Interferon T | 1995 |
The role of protein kinase C in inducing Alzheimer's A68 protein expression in the culture of human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Humans; Immunoblotting; Immun | 1994 |
Retinoic acid-stimulated intercellular adhesion molecule-1 expression on SK-N-SH cells: calcium/calmodulin-dependent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Pro | 1994 |
Transduction of retinoic acid and gamma-interferon signal for intercellular adhesion molecule-1 expression on human tumor cell lines: evidence for the late-acting involvement of protein kinase C inactivation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Adhesion Molecules; Enzyme Activation | 1993 |
Inhibition of neurite outgrowth in neuroblastoma cells by sphingosine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Blood; Culture Media; Isoquinolines; | 1993 |
Desensitization of acetylcholine induced inositol 1,4,5-trisphosphate formation in neuroblastoma SH-SY5Y cells following repetitive acetylcholine stimulations.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Alkaloids; Animals; Down-Regulation; E | 1993 |
Neurite outgrowth from N18TG2 neuroblastoma induced by H-7, a protein kinase inhibitor, in the presence of colchicine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Colchicine; Cytochalasin B; Isoquinolines; N | 1993 |
Thyroid hormones stabilize acetylcholinesterase mRNA in neuro-2A cells that overexpress the beta 1 thyroid receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine | 1995 |
Phosphoinositide signalling in human neuroblastoma cells: biphasic effect of Li+ on the level of the inositolphosphate second messengers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Atropine; Calcium; Egtazic Acid; Enzym | 1996 |
H7, an inhibitor of protein kinase C, prevents serum-induced phosphorylation of Raf and MAP kinase in neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Physiological Phenomena; Calcium-Calmo | 1996 |
1-(5-Isoquinolinesulfonyl)-2-methylpiperazine induces apoptosis in human neuroblastoma cells, SH-SY5Y, through a p53-dependent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Cell Nucleus; Enzyme Inhibitors; Half-Life | 1997 |
Inhibition of M3 muscarinic acetylcholine receptor-mediated Ca2+ influx and intracellular Ca2+ mobilization in neuroblastoma cells by the Ca2+/calmodulin-dependent protein kinase inhibitor 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-trosyl]-4-phenylpipe
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium-Calmodulin-Dependent Protein Kinases | 1997 |
Overexpression of alpha and beta isoforms of Ca2+/calmodulin-dependent protein kinase II in neuroblastoma cells -- H-7 promotes neurite outgrowth.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Benzylamines; Calcium-C | 1997 |
Neurite outgrowth of neuroblastoma cells overexpressing alpha and beta isoforms of Ca2+/calmodulin-dependent protein kinase II-effects of protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase | 1998 |
Lithium attenuates p53 levels in human neuroblastoma SH-SY5Y cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Humans; Lithium; Neuroblastoma; Osmolar Co | 1999 |
Retinoic acid confers resistance to p53-dependent apoptosis in SH-SY5Y neuroblastoma cells by modulating nuclear import of p53.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; DNA Fragmentation; Drug Resistance; Etopos | 1999 |
Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antipsychotic Agents; Bipolar Disorder; Calcium; Calc | 1999 |
Modulation of choline acetyltransferase synthesis by okadaic acid, a phosphatase inhibitor, and KN-62, a CaM kinase inhibitor, in NS-20Y neuroblastoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases | 2001 |
Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Blotting, Western; Caspase 2; Caspase 3; C | 2000 |
Differential effects of the protein kinase C inhibitors H7 and calphostin C on the cell cycle of neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Cycle; Cell Membrane Permeability; Cell | 1992 |
Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcimycin; Cyclic AMP; Egtazic A | 1992 |
Role of protein kinase C in short-term transmission at the mammalian neuromuscular junction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Botulinum Toxins; Calcium; Isoquinolines; Ne | 1992 |
Opposing influences of protein kinase activities on neurite outgrowth in human neuroblastoma cells: initiation by kinase A and restriction by kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bucladesine; Colforsin; Humans; Immunohist | 1992 |
Analysis of CD4 gene expression in human fetal brain and neuroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Base Sequence; Brain; CD4 Antigens; Cell Differentiat | 1992 |
Regulation of neurite outgrowth through protein kinase C and protease nexin-1 in neuroblastoma cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Cycloheximide; Dactinomycin; | 1992 |
H7, a protein kinase C inhibitor, increases the glutathione content of neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Enzyme Activation; Glutathione; I | 1992 |
Morphology of neurites from N18TG2 cell induced by protein kinase inhibitor H-7 and by cAMP.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Bucladesine; Cell Line; Colchicine; C | 1991 |
Inhibition of protein kinase C induces differentiation in Neuro-2a cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholinesterase; Animals; Cell Differentiation; | 1990 |
Staurosporine-induced morphological differentiation of human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Axons; Cell Differentiation; Colchicine; C | 1991 |
Protein kinase C is involved in desensitization of muscarinic receptors induced by phorbol esters but not by receptor agonists.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carbachol; Cyclic GMP; Down-Regu | 1990 |
A specific inhibitor of protein kinase C induces differentiation of neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Cell Differentiati | 1990 |
Muscarinic receptor-mediated translocation of calmodulin in SK-N-SH human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Biological Transport; Calcium; Cal | 1990 |
The specific inhibitor of protein kinase C, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7), induces morphological change and cell differentiation of human neural crest-derived cell lineages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Differentiation; Dose-Response Relationship, Dru | 1990 |
Protein kinase C activation and down-regulation in relation to phorbol ester-induced differentiation of SH-SY5Y human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium Channels; Cell Compartmentation; Cel | 1989 |
Neurite outgrowth from mouse neuroblastoma and cerebellar cells induced by the protein kinase inhibitor H-7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Cell Division; Cell Line; Cereb | 1989 |
Inhibition of protein kinase C induces differentiation of neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Differentiation; Cell Survival; Isoquin | 1989 |
A novel enhancement of SV40 enhancer activity by treatment of mouse neuroblastoma N18TG2 with protein kinase inhibitor H-7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Enhancer Elements, Genetic; Gene | 1988 |
Phorbol ester-induced inhibition of cyclic GMP formation mediated by muscarinic receptors in murine neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carbachol; Cell Line; Cyclic GMP | 1987 |
Decline in c-myc mRNA expression but not the induction of c-fos mRNA expression is associated with differentiation of SH-SY5Y human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Differentiation; Cell Line; Diglycerides; Gene E | 1988 |
Differential regulation of phosphatidylcholine biosynthesis by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol in NG108-15 neuroblastoma x glioma hybrid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Choline; Chromatography, High Pressure Liqui | 1987 |