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1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Nervous System Disorders

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Nervous System Disorders in 4 studies

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.

Research Excerpts

ExcerptRelevanceReference
"The effects of an intracellular calcium antagonist fasudil (HA 1077) on protein synthesis, ion derangement, brain edema, and the neurological signs associated with focal cerebral ischemia, were investigated via a nine-hour occlusion of the left common carotid artery (CCA) in Mongolian gerbils."7.69Fasudil (HA1077), an intracellular calcium antagonist, improves neurological deficits and tissue potassium loss in focal cerebral ischemia in gerbils. ( Kondoh, Y; Mizusawa, S; Murakami, M; Nagata, K; Nakamichi, H, 1997)
" This study analyzed the morphological, biochemical, and functional features of OPHN1-deficient h-iPSCs and their rescue by treatment with the ROCK inhibitor fasudil, shedding light on the relevance of the ROCK pathway during neuronal differentiation and providing a neuronal model for human OPHN1 syndrome and its treatment."3.83Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function. ( Alfieri, P; Barresi, S; Bertini, E; Billuart, P; Chiurazzi, P; Compagnucci, C; Petrini, S; Piccini, G; Zanni, G, 2016)
"The effects of an intracellular calcium antagonist fasudil (HA 1077) on protein synthesis, ion derangement, brain edema, and the neurological signs associated with focal cerebral ischemia, were investigated via a nine-hour occlusion of the left common carotid artery (CCA) in Mongolian gerbils."3.69Fasudil (HA1077), an intracellular calcium antagonist, improves neurological deficits and tissue potassium loss in focal cerebral ischemia in gerbils. ( Kondoh, Y; Mizusawa, S; Murakami, M; Nagata, K; Nakamichi, H, 1997)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Compagnucci, C1
Barresi, S1
Petrini, S1
Billuart, P1
Piccini, G1
Chiurazzi, P1
Alfieri, P1
Bertini, E1
Zanni, G1
Lu, Q1
Longo, FM1
Zhou, H1
Massa, SM1
Chen, YH1
Kondoh, Y1
Mizusawa, S1
Murakami, M1
Nakamichi, H1
Nagata, K1
Tanaka, Y1
Masuzawa, T1
Saito, M1
Yamada, T1
Ebihara, A1
Iwasa, H1
Mori, S1

Other Studies

4 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Nervous System Disorders

ArticleYear
Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function.
    Stem cells translational medicine, 2016, Volume: 5, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Differentiation; Cell Shape; Cells, Cultured; Cy

2016
Signaling through Rho GTPase pathway as viable drug target.
    Current medicinal chemistry, 2009, Volume: 16, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Aminoquinolines; Anilides; Animals; Benzamide

2009
Fasudil (HA1077), an intracellular calcium antagonist, improves neurological deficits and tissue potassium loss in focal cerebral ischemia in gerbils.
    Neurological research, 1997, Volume: 19, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Body Water; Brain; Brain Edema; Brain Ischem

1997
Combined administration of Fasudil hydrochloride and nitroglycerin for treatment of cerebral vasospasm.
    Acta neurochirurgica. Supplement, 2001, Volume: 77

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Brain Ischemia; Drug Combinations; Female; Huma

2001