1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Nerve Degeneration in 10 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmed, LA | 1 |
| Darwish, HA | 1 |
| Abdelsalam, RM | 1 |
| Amin, HA | 1 |
| Fujimura, M | 1 |
| Usuki, F | 1 |
| Kawamura, M | 1 |
| Izumo, S | 1 |
| Zhang, M | 1 |
| Shan, H | 1 |
| Gu, Z | 1 |
| Wang, D | 1 |
| Wang, T | 1 |
| Wang, Z | 1 |
| Tao, L | 1 |
| Tönges, L | 1 |
| Frank, T | 1 |
| Tatenhorst, L | 1 |
| Saal, KA | 1 |
| Koch, JC | 1 |
| Szego, ÉM | 1 |
| Bähr, M | 1 |
| Weishaupt, JH | 1 |
| Lingor, P | 1 |
| Wang, HL | 1 |
| Hu, SH | 1 |
| Chou, AH | 1 |
| Wang, SS | 1 |
| Weng, YH | 1 |
| Yeh, TH | 1 |
| Kitaoka, Y | 2 |
| Kumai, T | 1 |
| Lam, TT | 1 |
| Kuribayashi, K | 1 |
| Isenoumi, K | 1 |
| Munemasa, Y | 1 |
| Motoki, M | 1 |
| Kobayashi, S | 1 |
| Ueno, S | 1 |
| Huang, L | 1 |
| He, Z | 1 |
| Guo, L | 1 |
| Wang, H | 1 |
| Ito, T | 1 |
| Ohtori, S | 1 |
| Hata, K | 1 |
| Inoue, G | 1 |
| Moriya, H | 1 |
| Takahashi, K | 1 |
| Yamashita, T | 1 |
| Rundén, E | 1 |
| Seglen, PO | 1 |
| Haug, FM | 1 |
| Ottersen, OP | 1 |
| Wieloch, T | 1 |
| Shamloo, M | 1 |
| Laake, JH | 1 |
| Mattson, MP | 1 |
10 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Nerve Degeneration
| Article | Year |
|---|---|
Role of Rho Kinase Inhibition in the Protective Effect of Fasudil and Simvastatin Against 3-Nitropropionic Acid-Induced Striatal Neurodegeneration and Mitochondrial Dysfunction in Rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; bcl-2-Associated X Protein; Behavior, Animal | 2016 |
Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Botulinum Toxins; Down-Regulation; Male; Met | 2011 |
Increased expression of calcium/calmodulin-dependent protein kinase type II subunit δ after rat traumatic brain injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Brain Injuries; Calcium Signaling | 2012 |
Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-4-phenylpyridinium; Animals; Axons; Behavior | 2012 |
H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Ataxin-3; Ataxin-7; Brain; Dose-Resp | 2013 |
Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Count; Disease Models, Animal; Drug Int | 2004 |
Improvement of cognitive deficit and neuronal damage in rats with chronic cerebral ischemia via relative long-term inhibition of rho-kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Infarction; Brain Ischemia; Cerebral C | 2008 |
Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anterior Horn Cells; Axons; Behavior, Animal | 2007 |
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Apoptosis; Benzylamines; Calci | 1998 |
Evidence for the involvement of protein kinase C in neurodegenerative changes in cultured human cortical neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Survival; Cells, Cultured; Cerebral Cortex; Fetu | 1991 |