1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Nephrosclerosis in 2 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Nephrosclerosis: Hardening of the KIDNEY due to infiltration by fibrous connective tissue (FIBROSIS), usually caused by renovascular diseases or chronic HYPERTENSION. Nephrosclerosis leads to renal ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Late fasudil treatment significantly improved kidney function, morphological changes, and alterations of mRNA expression in the renal cortex, although late untreated controls did not show any improvement." | 5.35 | Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats. ( Akimoto, K; Inaba, C; Koshikawa, S; Matsuoka, H; Nishikimi, T, 2008) |
| "We examined whether the Rho/Rho-kinase pathway is involved in the pathogenesis of nephrosclerosis in severely hypertensive rats and assessed the effects of long-term treatment with a Rho-kinase inhibitor, fasudil, on kidney function, histological findings, gene expressions, and survival." | 3.74 | Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats. ( Akimoto, K; Inaba, C; Ishikawa, Y; Ishimura, K; Koshikawa, S; Matsuoka, H; Nishikimi, T; Ono, H, 2007) |
| "Late fasudil treatment significantly improved kidney function, morphological changes, and alterations of mRNA expression in the renal cortex, although late untreated controls did not show any improvement." | 1.35 | Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats. ( Akimoto, K; Inaba, C; Koshikawa, S; Matsuoka, H; Nishikimi, T, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koshikawa, S | 2 |
| Nishikimi, T | 2 |
| Inaba, C | 2 |
| Akimoto, K | 2 |
| Matsuoka, H | 2 |
| Ishikawa, Y | 1 |
| Ishimura, K | 1 |
| Ono, H | 1 |
2 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Nephrosclerosis
| Article | Year |
|---|---|
Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Collagen Type I; Collagen Type III; Drug Int | 2008 |
Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Collagen Type I; Collagen Type III; Gene Exp | 2007 |