1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Muscular Atrophy, Spinal in 2 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Muscular Atrophy, Spinal: A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil was administered by oral gavage from post-natal day 3 to 21 at a concentration of 30 mg/kg twice daily." | 1.38 | Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy. ( Anderson, CL; Bowerman, M; Boyer, JG; Kothary, R; Murray, LM, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hensel, N | 1 |
| Baskal, S | 1 |
| Walter, LM | 1 |
| Brinkmann, H | 1 |
| Gernert, M | 1 |
| Claus, P | 1 |
| Bowerman, M | 1 |
| Murray, LM | 1 |
| Boyer, JG | 1 |
| Anderson, CL | 1 |
| Kothary, R | 1 |
2 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Muscular Atrophy, Spinal
| Article | Year |
|---|---|
ERK and ROCK functionally interact in a signaling network that is compensationally upregulated in Spinal Muscular Atrophy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzimidazoles; Cell Death; Cell Line; Cytop | 2017 |
Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anterior Horn Cells; Disease Models, Animal; | 2012 |