1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Muscle Contraction in 140 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Airway smooth muscle contraction is not caused by the increase in intracellular Ca(2+) ([Ca(2+)](i)) alone because agonist stimulation increases tension at the same [Ca(2+)](i) (increase in Ca(2+) sensitivity)." | 5.35 | Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction. ( Chiba, Y; Hanazaki, M; Kohjitani, A; Misawa, M; Morita, K; Sakai, H; Yokoyama, M, 2008) |
| " Fasudil, a selective Rho-kinase inhibitor developed in Japan, is effective for the treatment of a wide range of cardiovascular diseases, with reasonable safety." | 4.84 | Progress of the study of rho-kinase and future perspective of the inhibitor. ( Shimokawa, H; Tawara, S, 2007) |
| "The involvement of Rho-associated kinase (ROK) in activation of rabbit urethral smooth muscle contraction was investigated by examining the effects of two structurally distinct inhibitors of ROK, Y27632 and H1152, on the contractile response to electric field stimulation, membrane depolarization with KCl, and α1-adrenoceptor stimulation with phenylephrine." | 3.77 | Rho-associated kinase plays a role in rabbit urethral smooth muscle contraction, but not via enhanced myosin light chain phosphorylation. ( Cole, WC; Hollywood, M; McHale, N; Sergeant, G; Thornbury, K; Walsh, MP, 2011) |
| "We previously showed that lower esophageal spincter (LES) tone depends on spontaneous production of inositol 1,4,5-trisphosphate (IP3) and release of intracellular Ca2+ and that acute experimental esophagitis reduces LES tone and IP3 production, suggesting damage to mechanisms responsible for release of Ca2+ from intracellular stores." | 3.69 | Experimental esophagitis affects intracellular calcium stores in the cat lower esophageal sphincter. ( Behar, J; Biancani, P; Kim, N; Rich, H; Sohn, UD, 1997) |
| "The Ca2+ channel antagonists nifedipine and verapamil each significantly inhibited (50-100%) the smooth muscle contraction induced in response to either 5-hydroxytryptamine (1 microM, 5-HT) or 20 mM K+ (K(+)-physiological salt solution) in the basilar artery." | 3.68 | Ca2+ channel antagonists and inhibition of protein kinase C each block contraction but not depolarization to 5-hydroxytryptamine in the rabbit basilar artery. ( Clark, AH; Garland, CJ, 1993) |
| " Direct stimulation of protein kinase C with phorbol 12,13-dibutyrate (PDBu) produced sustained smooth muscle contraction which was fairly rapid in onset and could be reversed by H7 but not by NCDC." | 3.68 | 5-hydroxytryptamine-stimulated accumulation of 1,2-diacylglycerol in the rabbit basilar artery: a role for protein kinase C in smooth muscle contraction. ( Clark, AH; Garland, CJ, 1991) |
| "Fasudil treated SJL/J mice showed increased body weight, but decreased grip strength, horizontal activity, and soleus muscle force, compared to untreated SJL/J controls." | 1.36 | Characterization of dysferlin deficient SJL/J mice to assess preclinical drug efficacy: fasudil exacerbates muscle disease phenotype. ( Gordish-Dressman, H; Hoffman, EP; Knoblach, SM; Nagaraju, K; Rayavarapu, S; Van der Meulen, JH, 2010) |
| "Adenosine (10 microM) was used as other contractile agent for comparison." | 1.35 | Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis. ( Gok, S; Izanli-Paksoy, A; Vural, K, 2009) |
| "Airway smooth muscle contraction is not caused by the increase in intracellular Ca(2+) ([Ca(2+)](i)) alone because agonist stimulation increases tension at the same [Ca(2+)](i) (increase in Ca(2+) sensitivity)." | 1.35 | Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction. ( Chiba, Y; Hanazaki, M; Kohjitani, A; Misawa, M; Morita, K; Sakai, H; Yokoyama, M, 2008) |
| "Delayed cerebral vasospasm after subarachnoid hemorrhage (SAH) may be due, in part, to altered regulation of arterial smooth muscle contraction." | 1.33 | Activation of Rho-associated kinase during augmented contraction of the basilar artery to serotonin after subarachnoid hemorrhage. ( Faraci, FM; Heistad, DD; Watanabe, Y, 2005) |
| "Caffeine treatment also resulted in increased phosphorylation of calmodulin-dependent protein kinase (CAMK)-II in epitrochlearis muscle." | 1.32 | Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions. ( Han, DH; Holloszy, JO; Hucker, KA; Wright, DC, 2004) |
| "When fasudil was combined with ONO-RS-082, fasudil exerted additional inhibition of the tension without further inhibition of the Ser19 phosphorylation." | 1.32 | Inhibition of protein kinase C-mediated contraction by Rho kinase inhibitor fasudil in rabbit aorta. ( Ikeda, M; Ito, K; Iwanaga, T; Sasaki, Y; Seto, M; Shimomura, E; Shiraishi, M, 2004) |
| " Dose-response curves for ET-1 relaxation were shifted to the left." | 1.29 | Two receptor subtypes are involved in the contractile component of the guinea pig ileum responses to endothelins. ( Ihara, M; Miasiro, N; Paiva, AC; Yano, M, 1993) |
| "Jatrophone was equipotent to H-7, but 100 to 500 fold less potent than staurosporine." | 1.29 | The relaxant action of jatrophone in rat portal vein. A comparison with protein kinase C inhibitors. ( Brum, RL; Calixto, JB; Silva, AM, 1995) |
| "Pretreatment with nifedipine (10(-6) M) did not reduce IPs formation." | 1.29 | Endothelin-1-induced phosphoinositide hydrolysis and contraction in isolated rabbit detrusor and urethral smooth muscle. ( Andersson, KE; Garcia-Pascual, A; Holmquist, F; Persson, K, 1993) |
| " The dose-response curve of HA1077 for MLC20 phosphorylation was to the left of the tension curve produced by 40 mM K+." | 1.28 | Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle. ( Hidaka, H; Sasaki, Y; Seto, M, 1991) |
| "When histamine 10(-5) M was applied, [Ca2+]i abruptly rose and reached the first peak within several seconds." | 1.28 | Temporal changes in the calcium-force relation during histamine-induced contractions of strips of the coronary artery of the pig. ( Abe, S; Hirano, K; Kanaide, H; Nakamura, M, 1991) |
| " H-7 produced a shift to the right of the dose-response curve for the PKC activator, 12-o-tetradecanoylphorbol-13-acetate (TPA) in the case of SHR aortas, while no such shift was noted in tissues from WKY." | 1.28 | Effects of H-7 (protein kinase inhibitor) and phorbol ester on aortic strips from spontaneously hypertensive rats. ( Iwasaki, T; Miyata, S; Morita, S; Nagai, K; Shibata, R, 1990) |
| "Ebselen is a new anti-inflammatory drug with a wide spectrum of pharmacological activities." | 1.28 | Ebselen inhibits contractile responses of guinea-pig parenchymal lung strips. ( Bast, A; Leurs, R; Timmerman, H, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (5.00) | 18.7374 |
| 1990's | 70 (50.00) | 18.2507 |
| 2000's | 41 (29.29) | 29.6817 |
| 2010's | 22 (15.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ishida, H | 1 |
| Saito, SY | 1 |
| Hishinuma, E | 1 |
| Kitayama, T | 1 |
| Ishikawa, T | 2 |
| Domokos, D | 1 |
| Ducza, E | 1 |
| Gáspár, R | 1 |
| Lan, B | 1 |
| Wang, L | 1 |
| Zhang, J | 1 |
| Pascoe, CD | 1 |
| Norris, BA | 1 |
| Liu, JC | 1 |
| Solomon, D | 1 |
| Paré, PD | 1 |
| Deng, L | 1 |
| Seow, CY | 1 |
| Porras-González, C | 2 |
| González-Rodríguez, P | 1 |
| Calderón-Sánchez, E | 1 |
| López-Barneo, J | 1 |
| Ureña, J | 2 |
| Anderson, CD | 1 |
| Kendig, DM | 1 |
| Al-Qudah, M | 1 |
| Mahavadi, S | 1 |
| Murthy, KS | 1 |
| Grider, JR | 1 |
| Egea-Guerrero, JJ | 1 |
| Murillo-Cabezas, F | 1 |
| Muñoz-Sánchez, MÁ | 1 |
| Vilches-Arenas, A | 1 |
| Castellano, A | 1 |
| González-Montelongo, Mdel C | 1 |
| Wang, B | 1 |
| Ding, YM | 1 |
| Wang, CT | 1 |
| Wang, WX | 1 |
| Aydinoglu, F | 1 |
| Ergurhan Kiroglu, O | 1 |
| Astarci, E | 1 |
| Balli, E | 1 |
| Ogulener, N | 1 |
| Colhoun, AF | 1 |
| Speich, JE | 3 |
| Dolat, MT | 1 |
| Habibi, JR | 1 |
| Guruli, G | 1 |
| Ratz, PH | 7 |
| Barbee, RW | 1 |
| Klausner, AP | 2 |
| Behuliak, M | 1 |
| Vavřínová, A | 1 |
| Bencze, M | 1 |
| Polgárová, K | 1 |
| Ergang, P | 1 |
| Kuneš, J | 1 |
| Vaněčková, I | 1 |
| Zicha, J | 1 |
| Sims, SM | 1 |
| Chrones, T | 1 |
| Preiksaitis, HG | 1 |
| Gok, S | 1 |
| Izanli-Paksoy, A | 1 |
| Vural, K | 1 |
| Tatsumiya, K | 1 |
| Yamanishi, T | 1 |
| Watanabe, M | 1 |
| Masuda, A | 1 |
| Mizuno, T | 1 |
| Kamai, T | 1 |
| Yoshida, K | 1 |
| Priviero, FB | 2 |
| Jin, LM | 1 |
| Ying, Z | 3 |
| Teixeira, CE | 3 |
| Webb, RC | 3 |
| Kizub, IV | 1 |
| Pavlova, OO | 1 |
| Johnson, CD | 1 |
| Soloviev, AI | 2 |
| Zholos, AV | 1 |
| Walsh, MP | 4 |
| Thornbury, K | 1 |
| Cole, WC | 1 |
| Sergeant, G | 1 |
| Hollywood, M | 1 |
| McHale, N | 1 |
| Rayavarapu, S | 1 |
| Van der Meulen, JH | 1 |
| Gordish-Dressman, H | 1 |
| Hoffman, EP | 1 |
| Nagaraju, K | 1 |
| Knoblach, SM | 1 |
| Bednarek, ML | 1 |
| Miner, AS | 3 |
| Robles, JC | 1 |
| Sturek, M | 1 |
| Parker, JL | 1 |
| Heaps, CL | 1 |
| Clelland, LJ | 1 |
| Browne, BM | 1 |
| Alvarez, SM | 1 |
| Saito, M | 4 |
| Ohmasa, F | 1 |
| Shomori, K | 1 |
| Dimitriadis, F | 1 |
| Ohiwa, H | 1 |
| Shimizu, S | 1 |
| Tsounapi, P | 1 |
| Kinoshita, Y | 1 |
| Satoh, K | 1 |
| Alford, PW | 2 |
| Dabiri, BE | 1 |
| Goss, JA | 1 |
| Hemphill, MA | 1 |
| Brigham, MD | 1 |
| Parker, KK | 2 |
| Nesmith, AP | 1 |
| Seywerd, JN | 1 |
| Grosberg, A | 1 |
| Southern, JB | 1 |
| Henderson, S | 1 |
| Wilson, CW | 1 |
| Inoue, S | 1 |
| Takenaka, A | 1 |
| Meehl, JT | 1 |
| Eddinger, TJ | 1 |
| Hoka, S | 1 |
| Shimokawa, H | 4 |
| Büyükafşar, K | 3 |
| Levent, A | 3 |
| Ark, M | 1 |
| Kandabashi, T | 1 |
| Miyata, K | 1 |
| Kunihiro, I | 1 |
| Eto, Y | 1 |
| Morishige, K | 1 |
| Matsumoto, Y | 1 |
| Obara, K | 1 |
| Nakayama, K | 2 |
| Takahashi, S | 1 |
| Takeshita, A | 2 |
| Breitenlechner, C | 1 |
| Gassel, M | 1 |
| Hidaka, H | 6 |
| Kinzel, V | 1 |
| Huber, R | 1 |
| Engh, RA | 1 |
| Bossemeyer, D | 1 |
| Wright, DC | 1 |
| Hucker, KA | 1 |
| Holloszy, JO | 1 |
| Han, DH | 1 |
| Nakayama, M | 1 |
| Amano, M | 1 |
| Kawabata, S | 1 |
| Kaibuchi, K | 1 |
| Takefuji, M | 1 |
| Smith, NC | 1 |
| Burnstock, G | 1 |
| Shimomura, E | 1 |
| Shiraishi, M | 1 |
| Iwanaga, T | 1 |
| Seto, M | 4 |
| Sasaki, Y | 6 |
| Ikeda, M | 1 |
| Ito, K | 2 |
| Ruddock, MW | 1 |
| Hirst, DG | 1 |
| Watanabe, Y | 1 |
| Faraci, FM | 1 |
| Heistad, DD | 1 |
| Orlando, KA | 1 |
| Stone, NL | 1 |
| Pittman, RN | 1 |
| Xie, Z | 1 |
| Su, W | 1 |
| Guo, Z | 1 |
| Pang, H | 1 |
| Post, SR | 1 |
| Gong, MC | 1 |
| Amobi, NI | 1 |
| Chung, IP | 1 |
| Smith, IC | 1 |
| Takahashi, R | 1 |
| Nishimura, J | 2 |
| Seki, N | 1 |
| Yunoki, T | 1 |
| Tomoda, T | 1 |
| Kanaide, H | 5 |
| Naito, S | 1 |
| Tawara, S | 1 |
| Jin, L | 1 |
| Hanazaki, M | 1 |
| Yokoyama, M | 1 |
| Morita, K | 1 |
| Kohjitani, A | 1 |
| Sakai, H | 1 |
| Chiba, Y | 1 |
| Misawa, M | 1 |
| Miasiro, N | 1 |
| Paiva, AC | 1 |
| Ihara, M | 1 |
| Yano, M | 1 |
| Jiang, MJ | 1 |
| Chan, CF | 1 |
| Chang, YL | 1 |
| Low, AM | 1 |
| Loke, JC | 1 |
| Kwan, CY | 1 |
| Daniel, EE | 1 |
| Sakai, Y | 1 |
| Inazu, M | 1 |
| Shamoto, A | 1 |
| Zhu, B | 1 |
| Homma, I | 1 |
| McKenna, TM | 1 |
| Clegg, JM | 1 |
| Williams, TJ | 1 |
| Sasajima, H | 2 |
| Shima, H | 2 |
| Toyoda, Y | 2 |
| Nishio, I | 2 |
| Silva, AM | 1 |
| Brum, RL | 1 |
| Calixto, JB | 1 |
| Okatani, Y | 1 |
| Taniguchi, K | 1 |
| Sagara, Y | 1 |
| Yang, KX | 1 |
| Black, JL | 1 |
| Takizawa, S | 1 |
| Hori, M | 1 |
| Ozaki, H | 1 |
| Karaki, H | 1 |
| Yu, P | 4 |
| De Petris, G | 3 |
| Biancani, P | 7 |
| Amaral, J | 2 |
| Behar, J | 6 |
| Tansey, MG | 1 |
| Luby-Phelps, K | 1 |
| Kamm, KE | 1 |
| Stull, JT | 1 |
| Harnett, KM | 2 |
| Sohn, UD | 2 |
| Rhim, BY | 1 |
| Hillemeier, C | 2 |
| Bitar, KN | 3 |
| Matsui, T | 4 |
| Kaizu, H | 1 |
| Itoh, S | 1 |
| Asano, T | 6 |
| Tagawa, H | 1 |
| Tomoike, H | 1 |
| Mitsuoka, W | 1 |
| Satoh, S | 4 |
| Kuga, T | 1 |
| Nakamura, M | 3 |
| Souhrada, M | 2 |
| Souhrada, JF | 2 |
| Garcia-Pascual, A | 2 |
| Persson, K | 2 |
| Holmquist, F | 2 |
| Andersson, KE | 2 |
| Watanabe, C | 1 |
| Hirano, K | 4 |
| Clark, AH | 2 |
| Garland, CJ | 2 |
| De Diego, A | 1 |
| Cortijo, J | 1 |
| Villagrasa, V | 1 |
| Perpiñá, M | 1 |
| Esplugues, J | 1 |
| Morcillo, EJ | 1 |
| Sohn, U | 1 |
| Chrzanowska-Wodnicka, M | 1 |
| Burridge, K | 1 |
| Honda, K | 1 |
| Takano, Y | 1 |
| Kamiya, H | 1 |
| Oriji, GK | 2 |
| Keiser, HR | 2 |
| Karibe, A | 1 |
| Watanabe, J | 1 |
| Horiguchi, S | 1 |
| Takeuchi, M | 1 |
| Suzuki, S | 1 |
| Funakoshi, M | 1 |
| Katoh, H | 1 |
| Keitoku, M | 1 |
| Shirato, K | 1 |
| Chen, Q | 2 |
| Miranda, FJ | 1 |
| Alabadí, JA | 1 |
| Pérez, P | 1 |
| Ortí, M | 1 |
| Centeno, JM | 1 |
| Yuste, A | 1 |
| Sanz-Cervera, JF | 1 |
| Marco, JA | 1 |
| Alborch, E | 1 |
| Rich, H | 1 |
| Kim, N | 1 |
| Kimura, K | 1 |
| Yoshikawa, A | 1 |
| Hano, T | 1 |
| Satoh, M | 1 |
| Hayasaka, M | 1 |
| Horiuchi, K | 1 |
| Takayanagi, I | 1 |
| Uchida, K | 1 |
| Yuzuki, R | 1 |
| Kamikawa, Y | 1 |
| Xiao, Z | 1 |
| Harnett, K | 1 |
| Tian, B | 1 |
| Millar, C | 1 |
| Kaufman, PL | 1 |
| Bershadsky, A | 1 |
| Becker, E | 1 |
| Geiger, B | 1 |
| Hidalgo, A | 1 |
| Cantabrana, B | 1 |
| Pérez-Vallina, JR | 1 |
| Nagumo, H | 2 |
| Sakurada, K | 1 |
| Chakder, S | 1 |
| Rattan, S | 2 |
| Nunes, JP | 1 |
| Guimarães, S | 1 |
| Thieme, H | 1 |
| Nass, JU | 1 |
| Nuskovski, M | 1 |
| Bechrakis, NE | 1 |
| Stumpff, F | 1 |
| Strauss, O | 1 |
| Wiederholt, M | 1 |
| Swärd, K | 1 |
| Dreja, K | 1 |
| Susnjar, M | 1 |
| Hellstrand, P | 1 |
| Hartshorne, DJ | 1 |
| Parizi, M | 1 |
| Howard, EW | 1 |
| Tomasek, JJ | 1 |
| Ono, Y | 1 |
| Okamoto, H | 1 |
| Takuwa, Y | 3 |
| Supinski, G | 1 |
| Stofan, D | 1 |
| Callahan, LA | 1 |
| Nethery, D | 1 |
| DiMarco, A | 1 |
| Masumoto, N | 1 |
| Tanabe, Y | 1 |
| Horio, S | 1 |
| Fukui, H | 1 |
| Suenaga, H | 1 |
| Kamata, K | 1 |
| Nakamura, K | 1 |
| Ibayashi, S | 1 |
| Fujishima, M | 1 |
| Honjo, M | 1 |
| Inatani, M | 1 |
| Kido, N | 1 |
| Sawamura, T | 1 |
| Yue, BY | 1 |
| Honda, Y | 1 |
| Tanihara, H | 1 |
| Zhang, D | 1 |
| Wang, Z | 1 |
| Jin, N | 2 |
| Li, L | 1 |
| Rhoades, RA | 2 |
| Yancey, KW | 1 |
| Swartz, DR | 1 |
| Jezior, JR | 1 |
| Brady, JD | 1 |
| Rosenstein, DI | 1 |
| McCammon, KA | 1 |
| Utsunomiya, T | 1 |
| Tsurui, K | 1 |
| Kobayashi, T | 1 |
| Ikegaki, I | 2 |
| Wesselman, JP | 1 |
| Spaan, JA | 1 |
| van der Meulen, ET | 1 |
| VanBavel, E | 1 |
| Lamping, KG | 1 |
| Fan, YP | 1 |
| Puri, RN | 1 |
| Mita, M | 1 |
| Yanagihara, H | 1 |
| Hishinuma, S | 1 |
| Poon, AM | 1 |
| Kravtsov, GM | 1 |
| Pang, SF | 1 |
| Bershtein, SA | 1 |
| Day, RW | 1 |
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| Klitzner, TS | 1 |
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| Shibata, R | 1 |
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| Iwasaki, T | 1 |
| Leurs, R | 2 |
| Bast, A | 2 |
| Timmerman, H | 2 |
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| Hoshi, H | 1 |
| Mitsui, Y | 1 |
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| Shibuya, M | 1 |
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| Morita, R | 1 |
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| Miyashita, Y | 1 |
| Imanaka, S | 1 |
| Ogihara, T | 1 |
| Villalobos-Molina, R | 1 |
| Ransanz, V | 1 |
| Torres-Márquez, ME | 1 |
| Hong, E | 1 |
| García-Sáinz, JA | 1 |
| Kodama, M | 1 |
| Kai, H | 1 |
| Sugiura, M | 1 |
| Inagami, T | 1 |
| Hare, GM | 1 |
| Johns, JA | 1 |
| Auguet, M | 1 |
| Delaflotte, S | 1 |
| Chabrier, PE | 1 |
| Braquet, P | 1 |
| Go, JN | 1 |
| Tanaka, T | 1 |
| Inagaki, M | 1 |
| van Breemen, C | 1 |
5 reviews available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Muscle Contraction
| Article | Year |
|---|---|
[Basic and clinical studies on coronary vasospasm].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium Channel Blockers; Coronary Artery Disease; Co | 2002 |
[Involvement of small GTPase Rho and Rho-kinase in the pathogenesis of hypertension and hypertensive target organ damage].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Angina Pectoris; Animals; Arteriosclerosis; C | 2004 |
Progress of the study of rho-kinase and future perspective of the inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cardiovascular Diseases; Cell Proliferation; | 2007 |
[Molecular pharmacology of intracellular calcium signaling].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azepines; Calcium; Cyclic AMP; Humans; Isoqu | 1990 |
[Molecular pharmacology on intracellular calcium messenger system].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actomyosin; Binding Sites; Calcium; Calcium Channel B | 1986 |
135 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Muscle Contraction
| Article | Year |
|---|---|
Differential contribution of calcium channels to α
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Body Temperature Regulation; Calcium; Calciu | 2018 |
RhoA and Rho-kinase inhibitors modulate cervical resistance: The possible role of RhoA/Rho-kinase signalling pathway in cervical ripening and contractility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cervical Ripening; Cervix Uteri; Fem | 2019 |
Rho-kinase mediated cytoskeletal stiffness in skinned smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Calcium; Cell Shape; Cytoskel | 2013 |
Low-dose combination of Rho kinase and L-type Ca(2+) channel antagonists for selective inhibition of depolarization-induced sustained arterial contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Calcium; Calcium Channel Blockers; | 2014 |
Role of various kinases in muscarinic M3 receptor-mediated contraction of longitudinal muscle of rat colon.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Benzimidazoles; Calcium-Calmodulin-D | 2014 |
Role of L-type Ca(2+) channels, sarcoplasmic reticulum and Rho kinase in rat basilar artery contractile properties in a new model of subarachnoid hemorrhage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Calcium; Calcium Channel Blo | 2015 |
Role of ROCK expression in gallbladder smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bile; Cholesterol; Disease Models, Animal; G | 2015 |
Effects of ethanol on RhoA/Rho-kinase-mediated calcium sensitization in mouse lung parenchymal tissue.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Ethanol; Lung; Male; Mice; | 2015 |
Acute length adaptation and adjustable preload in the human detrusor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adaptation, Physiological; Enzyme Inhibitors; Female; | 2016 |
Ontogenetic changes in contribution of calcium sensitization and calcium entry to blood pressure maintenance of Wistar-Kyoto and spontaneously hypertensive rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Blood Pressure; Calcium; Calcium C | 2015 |
Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Benzophenanthridines; Calcium; Electric Stimu | 2008 |
Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Benzophenanthridines; Bronchodila | 2009 |
Effects of fasudil, a Rho-kinase inhibitor, on contraction of pig bladder tissues with or without urothelium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbachol; Cholinergic Agonists; Dose-Respon | 2009 |
Up-regulation of the RhoA/Rho-kinase signaling pathway in corpus cavernosum from endothelial nitric-oxide synthase (NOS), but not neuronal NOS, null mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cyclic GMP; Endothelium, Vascular; I | 2010 |
Rho kinase and protein kinase C involvement in vascular smooth muscle myofilament calcium sensitization in arteries from diabetic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Benzophenanthridines; Calcium; Dia | 2010 |
Rho-associated kinase plays a role in rabbit urethral smooth muscle contraction, but not via enhanced myosin light chain phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Electric Stimulation; Male; Muscle C | 2011 |
Characterization of dysferlin deficient SJL/J mice to assess preclinical drug efficacy: fasudil exacerbates muscle disease phenotype.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Drug Evaluation, Pre | 2010 |
Active tension adaptation at a shortened arterial muscle length: inhibition by cytochalasin-D.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Bridged Bicyclo Compounds, Heterocyc | 2011 |
Ca2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Collateral Circulation; Cor | 2011 |
Rho-kinase inhibition attenuates calcium-induced contraction in β-escin but not Triton X-100 permeabilized rabbit femoral artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cardiovascular Agents; Dose-Respons | 2011 |
Rhos and Rho kinases in the rat prostate: their possible functional roles and distributions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbachol; Immunoblotting; Immunohistochemis | 2011 |
Blast-induced phenotypic switching in cerebral vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Algorithms; Arteries; Blast Injuries; Blotting, Weste | 2011 |
Vascular smooth muscle contractility depends on cell shape.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Cell Nucleus; Cell Shape; Cells, | 2011 |
Adjustable passive stiffness in mouse bladder: regulated by Rho kinase and elevated following partial bladder outlet obstruction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbachol; Cholinergic Agonists; Dinoproston | 2012 |
Hydroxyfasudil ameliorates bladder dysfunction in male spontaneously hypertensive rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Hypertension; Male; Muscle Contraction; Musc | 2012 |
RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Amides; Animals; Carbachol | 2002 |
Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Amides; Animals; Carbachol; Electric S | 2003 |
Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Blotting, We | 2003 |
Evidence for protein kinase C-mediated activation of Rho-kinase in a porcine model of coronary artery spasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Calcium; Capillary Permea | 2003 |
Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Amino Acid Sequence; | 2003 |
Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylate Kinase; Animals; Benzylamines; Biological T | 2004 |
Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Atropine; Blotting, Western; | 2004 |
Mechanisms underlying postjunctional synergism between responses of the vas deferens to noradrenaline and ATP.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; | 2004 |
Inhibition of protein kinase C-mediated contraction by Rho kinase inhibitor fasudil in rabbit aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Enzyme Activation; In Vitro | 2004 |
Nicotinamide relaxes vascular smooth muscle by inhibiting myosin light chain kinase-dependent signaling pathways: implications for anticancer efficacy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calmodulin; Chickens; Dose-Response | 2004 |
Activation of Rho-associated kinase during augmented contraction of the basilar artery to serotonin after subarachnoid hemorrhage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Disease Models, Animal; Enzy | 2005 |
Proerectile effects of the Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine (H-1152) in the rat penis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Blood Pressure; Intracellular Signal | 2005 |
Rho kinase regulates fragmentation and phagocytosis of apoptotic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Animals; Apoptosis; Bridged Bicyclo C | 2006 |
Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Cells, Cultured; Diabetes Mel | 2006 |
Attenuation of contractility in rat epididymal vas deferens by Rho kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Azepines; Ca | 2006 |
RhoA/Rho kinase-mediated Ca2+ sensitization in the contraction of human prostate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Blotting, Western; Calcium; Cells, Cultured; | 2007 |
Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Atropine; Bl | 2007 |
Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Amides; Animals; Bronchi; Bronchoconst | 2008 |
Two receptor subtypes are involved in the contractile component of the guinea pig ileum responses to endothelins.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Endothelin Receptor Ant | 1993 |
Intracellular calcium and myosin light chain phosphorylation during U46619-activated vascular contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13 | 1994 |
Sensitivity to protein kinase C inhibitors of nicardipine-insensitive component of high K+ contracture in rat and guinea-pig aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Calcium; Guinea Pigs; Hyper | 1994 |
Contractile hyperreactivity and alteration of PKC activity in gastric fundus smooth muscle of diabetic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5 | 1994 |
Protein kinase C is a mediator of lipopolysaccharide-induced vascular suppression in the rat aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Oxidoreductases; Animals; Aorta; Arginine; | 1994 |
Role of protein kinase C in relationship between Ca2+ and contractile elements in rat alpha-toxin-permeabilized mesenteric artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bacterial Toxins; Calcium; Cell M | 1995 |
The relaxant action of jatrophone in rat portal vein. A comparison with protein kinase C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Caffeine; Calcium; Diterpenes; En | 1995 |
Amplifying effect of endothelin-1 on serotonin-induced vasoconstriction of human umbilical artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Calcium Chloride; Dose-Response | 1995 |
The involvement of protein kinase C in the contraction of human airway smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bronchi; Histamine; Humans; In Vitro Techn | 1995 |
Effects of isoquinoline derivatives, HA1077 and H-7, on cytosolic Ca2+ level and contraction in vascular smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Calcium; Cytosol; Isoquinolines; Male | 1993 |
Cholecystokinin-coupled intracellular signaling in human gallbladder muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzimidazoles; Calmodulin; Cholecystokinin; Diglycer | 1994 |
Ca(2+)-dependent phosphorylation of myosin light chain kinase decreases the Ca2+ sensitivity of light chain phosphorylation within smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Calcium; Calcium-Calmod | 1994 |
Differential signal transduction pathways in cat lower esophageal sphincter tone and response to ACh.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Analysis of Variance; Animals; Benzimi | 1994 |
Interaction between signal transduction pathways contributing to gallbladder tonic contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calmodulin; Cats; Diglycerides; Fem | 1993 |
The role of active smooth-muscle contraction in the occurrence of chronic vasospasm in the canine two-hemorrhage model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Dogs; Female; Ischemic Attac | 1994 |
Hyperreactivity of aortic smooth muscle to serotonin is related to the presence of atheroma in Watanabe heritable hyperlipidaemic rabbits.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Arteriosclerosis; Calcium; Culture Te | 1993 |
Inhibitory effect of staurosporine on protein kinase C stimulation of airway smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Alkaloids; Amiloride; Animals; Car | 1993 |
Endothelin-1-induced phosphoinositide hydrolysis and contraction in isolated rabbit detrusor and urethral smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Endotheli | 1993 |
Role of extracellular and intracellular sources of Ca2+ in sarafotoxin S6b-induced contraction of strips of the rat aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Caffeine; Calcium; Cytosol; | 1993 |
Ca2+ channel antagonists and inhibition of protein kinase C each block contraction but not depolarization to 5-hydroxytryptamine in the rabbit basilar artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Calcium Channel Blockers; Ca | 1993 |
Effects of phorbol 12,13-diacetate and its influence on spasmogenic responses in normal and sensitized guinea-pig trachea.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Calcium; Diuretics; Guinea Pigs; | 1995 |
Protein kinase C mediates spontaneous tone in the cat lower esophageal sphincter.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cats; Diglycerides; Esophagogastric Junction | 1996 |
Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Actin Cytoskeleton; Actins; Alkaloids; Ani | 1996 |
Involvement of protein kinase C in muscarinic agonist-induced contractions of guinea pig ileal longitudinal muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carbachol; Diglycerides; Guinea Pig | 1996 |
Cyclosporine A-induced contractions and prostacyclin release are maintained by extracellular calcium in rat aortic rings: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Calcium Channel Blockers; Cell Membra | 1997 |
Role of cytosolic Ca2+ and protein kinase C in developing myogenic contraction in isolated rat small arteries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Calcium; Cytosol; Femoral Artery; | 1997 |
Different pathways mediate cholecystokinin actions in cholelithiasis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzimidazoles; Benzophenanthridi | 1997 |
Analysis of rabbit vascular responses to DBI, an ingol derivative isolated from Euphorbia canariensis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Calcium; Calmodulin; Carotid | 1997 |
Experimental esophagitis affects intracellular calcium stores in the cat lower esophageal sphincter.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Analysis of Variance; Animals; Benzimi | 1997 |
Protein kinase C mediates angiotensin II-induced contractions and the release of endothelin and prostacyclin in rat aortic rings.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Dose-Respon | 1997 |
Increased Ca2+ sensitivity of contractile elements via protein kinase C in alpha-toxin permeabilized SMA from young spontaneously hypertensive rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Calcium; Enzyme Inhibi | 1997 |
Protein kinase C mediates increase of Ca2+ sensitivity for contraction by cholinoceptor partial agonist in ileal longitudinal muscle of guinea pig.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carbachol; Carbazoles; Cholinergic | 1998 |
The role of receptor-operated CA2+ influx in endothelin-induced contraction of the muscularis mucosae.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Endothelin Receptor Antagonists; En | 1998 |
Signal transduction pathways mediating CCK-induced gallbladder muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzimidazoles; Calcium; Calmodulin; Cats; C | 1998 |
Effects of H-7 on the iris and ciliary muscle in monkeys.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Accommodation, Ocular; Actomyosin; Animals | 1998 |
Contribution of cAMP to the inhibitory effect of non-steroidal anti-inflammatory drugs in rat uterine smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cal | 1998 |
HA1077, a protein kinase inhibitor, inhibits calponin phosphorylation on Ser175 in porcine coronary artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Calcium-Binding Proteins; Calponin | 1998 |
Mechanisms and sites of action of endothelins 1 and 2 on the opossum internal anal sphincter smooth muscle tone in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic Agents; Anal Canal; Animals; Atropine; Cal | 1999 |
The influence of the wall tension on the contractile responses of arteries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Arteries; E | 1999 |
The effects of protein kinase C on trabecular meshwork and ciliary muscle contractility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Animals; Blotting, Western; Carbachol; C | 1999 |
Inhibition of Rho-associated kinase blocks agonist-induced Ca2+ sensitization of myosin phosphorylation and force in guinea-pig ileum.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carbachol; Cholinergic Agonists; En | 2000 |
Regulation of LPA-promoted myofibroblast contraction: role of Rho, myosin light chain kinase, and myosin light chain phosphatase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Alkaloids; Azepines; Botulin | 2000 |
Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Blood Proteins; Calcium; Cells, Cultu | 2000 |
Effects of protein kinase A inhibition on rat diaphragm force generation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cyclic AMP-Dependent Protein Kinases; Diaphr | 2000 |
Attenuation of pressure-induced myogenic contraction and tyrosine phosphorylation by fasudil, a cerebral vasodilator, in rat cerebral artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell-Free System; Cerebral Arteries | 2000 |
Inhibition of oxotremorine-induced desensitization of guinea-pig ileal longitudinal muscle in Ca2+-free conditions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Calcium; Enzyme Inhibitors; G | 2001 |
Alpha-adrenoceptor agonists produce Ca2+ oscillations in isolated rat aorta: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; | 2000 |
Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Basilar Artery; Calc | 2001 |
Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Aqueous Humor; Blotting, Western; Ca | 2001 |
Microtubule disruption modulates the Rho-kinase pathway in vascular smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Antineoplastic Agents; Aorta; Azepin | 2001 |
Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE-908-sensitive channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetamides; Amides; Animals; Bethanechol; Calcium; Ca | 2001 |
Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Brain Ischemia; Cerebral Arteries; Do | 2001 |
Role of protein kinase C in myogenic calcium-contraction coupling of rat cannulated mesenteric small arteries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Catheterization; Enzyme Inhibitors; | 2001 |
Enhanced contractile mechanisms in vasospasm: is endothelial dysfunction the whole story?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Coronary Vasospasm; Endothelium, Va | 2002 |
Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anal Canal; Angiotensin II; Animals; Dose-Response Re | 2002 |
Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Arteries; Enzyme Inhibitors; In Vitr | 2002 |
Receptor-mediated modulation of avian caecal muscle contraction by melatonin: role of tyrosine protein kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apamin; Binding, Competitive; Cecum; Dose-Re | 2002 |
The contractile apparatus in vascular smooth muscle cells of spontaneously hypertensive rats possess increased calcium sensitivity: the possible role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Hypertension; Isoquinolines; Muscle | 1992 |
Endothelin-1-induced contractions of isolated pig detrusor and vesical arterial smooth muscle: calcium dependence and phosphoinositide hydrolysis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Calcium; Endothelins; Female; Hydr | 1992 |
Oxygen-mediated regulation of neonatal and adult rabbit aortic tension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Aorta; Arginine; Endothelium, Vascula | 1992 |
Effects of phorbol ester on lower urinary tract smooth muscles in rabbits.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbachol; Drug Interactions; Female; Isoqui | 1992 |
[A pharmacological study on the mechanism of the endothelin-induced contraction of the bovine cerebral artery].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcium | 1991 |
Existence of two components in the tonic contraction of rat aorta mediated by alpha 1-adrenoceptor activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; | 1991 |
Reactive oxygen-mediated contraction in pulmonary arterial smooth muscle: cellular mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagon | 1991 |
Low pH-induced release of calcitonin gene-related peptide from capsaicin-sensitive sensory nerves: mechanism of action and biological response.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5 | 1991 |
Hsp27 is a mediator of sustained smooth muscle contraction in response to bombesin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anal Canal; Animals; Antibodies, Monoclonal; Bombesin | 1991 |
Phorbol 12,13-diacetate-induced contraction of the canine basilar artery: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Basilar Artery; Cyclic GMP; Dinop | 1991 |
A selective effect of protein kinase C activators on noradrenaline release compared with subsequent contraction in canine isolated saphenous veins.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diterpenes; Dogs; Electric Stimulation; Enzy | 1991 |
Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Dinoprost; In Vitro Techniq | 1991 |
Activation of the protein kinase C-mediated contractile system in canine basilar artery undergoing chronic vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Chronic Disease; Dinoprost; | 1991 |
Norepinephrine-induced phosphatidylcholine hydrolysis in intact rat aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Hydrolysis; Isoquinolines; Male; Muscle Cont | 1991 |
A new type of vasodilator, HA1077, an isoquinoline derivative, inhibits proliferation of bovine vascular smooth muscle cells in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Calcium; Cattle; Cell Cycle; Cell Div | 1991 |
Imaging of protein kinase C distribution and translocation in living vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell Compartmentation; Cytosol; Fer | 1991 |
Possible role of protein kinase C-dependent smooth muscle contraction in the pathogenesis of chronic cerebral vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Basilar Artery; Diglycerides; Dog | 1991 |
5-hydroxytryptamine-stimulated accumulation of 1,2-diacylglycerol in the rabbit basilar artery: a role for protein kinase C in smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diglycerides; Female; In Vitro Techniques; I | 1991 |
Temporal changes in the calcium-force relation during histamine-induced contractions of strips of the coronary artery of the pig.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Coronary Vessels; Cytosol; Female; | 1991 |
Mechanisms of action of endothelin 1 in maturing rabbit airway smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Aging; Animals; Dinoprostone; Eicosano | 1991 |
[Calmodulin dependent regulation of smooth muscle contraction].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azepines; Calcium; Calmodulin; Isoquinolines | 1990 |
Effects of H-7 (protein kinase inhibitor) and phorbol ester on aortic strips from spontaneously hypertensive rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Calcimycin; | 1990 |
Ebselen inhibits contractile responses of guinea-pig parenchymal lung strips.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azo | 1990 |
Mode of stimulation of gallbladder contraction by substance K.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Atropine; Dose-Response Relat | 1990 |
Endothelin stimulates hypertrophy and contractility of neonatal rat cardiac myocytes in a serum-free medium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cells, Cultured; Endothelins; In Vi | 1990 |
Endothelin: a potential modulator of cerebral vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cerebral Arteries; Dogs; Endothelin | 1990 |
Effect of the kinase inhibitor, H-7, on stress, crossbridge phosphorylation, muscle shortening and inositol phosphate production in rabbit arteries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Female; In Vitro Techniques; Inosi | 1990 |
Participation of both intracellular free Ca2+ and protein kinase C in tonic vasoconstriction induced by prostaglandin F2 alpha.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Calcium; Dinoprost; Enzyme | 1990 |
Contrasting effects of phorbol dibutyrate and phorbol myristate acetate in rabbit aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Cells, Cultured; Epinephrine; In Vitr | 1990 |
Endothelin-induced Ca-independent contraction of the porcine coronary artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Caffeine; Calcium; Coronary Vessels; Dose-Re | 1989 |
The role of protein kinase-C in sensitization and antigen response of airway smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Antibody Specificity; Antigens; C | 1989 |
Endothelin action: Inhibition by a protein kinase C inhibitor and involvement of phosphoinositols.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Calcium; Dose-Response Relationship, | 1989 |
Comparative effects of endothelin and phorbol 12-13 dibutyrate in rat aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Calcium; Diltiazem; Endoth | 1989 |
Involvement of protein kinase C in the histamine H1-receptor mediated contraction of guinea-pig lung parenchymal strips.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Guinea Pigs; In Vitro Techniques; Isoquinoli | 1989 |
Sustained contraction of vascular smooth muscle: calcium influx or C-kinase activation?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Enzyme Activation; In Vitro Techniq | 1988 |