1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Multiple Sclerosis in 5 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil has been confirmed to improve experimental autoimmune encephalomyelitis (EAE), an animal model of MS." | 1.91 | Hydroxyfasudil regulates immune balance and suppresses inflammatory responses in the treatment of experimental autoimmune encephalomyelitis. ( Chu, GG; Ding, ZB; Huang, JJ; Ma, CG; Song, LJ; Wang, J; Wang, Q; Xiao, BG; Yin, JZ, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chu, GG | 1 |
| Wang, J | 1 |
| Ding, ZB | 1 |
| Yin, JZ | 1 |
| Song, LJ | 1 |
| Wang, Q | 1 |
| Huang, JJ | 1 |
| Xiao, BG | 2 |
| Ma, CG | 3 |
| Yan, Y | 1 |
| Yu, J | 2 |
| Gao, Y | 1 |
| Kumar, G | 1 |
| Guo, M | 1 |
| Zhao, Y | 1 |
| Fang, Q | 1 |
| Zhang, H | 1 |
| Jiang, Y | 1 |
| Zhang, HT | 1 |
| Chen, C | 1 |
| Yu, JZ | 1 |
| Zhang, Q | 1 |
| Zhao, YF | 1 |
| Liu, CY | 1 |
| Li, YH | 1 |
| Yang, WF | 1 |
| LoGrasso, PV | 1 |
| Feng, Y | 1 |
| Huang, XN | 1 |
| Fu, J | 1 |
| Wang, WZ | 1 |
2 reviews available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Multiple Sclerosis
| Article | Year |
|---|---|
Therapeutic potentials of the Rho kinase inhibitor Fasudil in experimental autoimmune encephalomyelitis and the related mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cytokines; Encephalomyelitis, Autoimmune, Ex | 2019 |
Rho kinase (ROCK) inhibitors and their application to inflammatory disorders.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Inflammatory Agents; Asthma; Humans; In | 2009 |
3 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Multiple Sclerosis
| Article | Year |
|---|---|
Hydroxyfasudil regulates immune balance and suppresses inflammatory responses in the treatment of experimental autoimmune encephalomyelitis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Encephalomyelitis, Autoimmune, Experimental; | 2023 |
Role of Rho Kinase and Fasudil on Synaptic Plasticity in Multiple Sclerosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adolescent; Adult; Animals; Cells, Cultured; Central | 2015 |
The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cord barrier following experimental autoimmune encephalomyelitis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood-Brain Barrier; Cell Membrane Permeabil | 2011 |