1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Morphine Abuse in 6 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Naloxone was proposed to act as a negative antagonist (inverse agonist) blocking mu* activity, whereas D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) appeared to act as a neutral antagonist having no effect on mu* activity." | 5.29 | Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice. ( Bernstein, RN; Bilsky, EJ; Porreca, F; Sadée, W; Wang, Z, 1996) |
| "Naloxone was proposed to act as a negative antagonist (inverse agonist) blocking mu* activity, whereas D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) appeared to act as a neutral antagonist having no effect on mu* activity." | 1.29 | Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice. ( Bernstein, RN; Bilsky, EJ; Porreca, F; Sadée, W; Wang, Z, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tokuyama, S | 2 |
| Feng, Y | 1 |
| Wakabayashi, H | 2 |
| Ho, IK | 2 |
| Bilsky, EJ | 1 |
| Bernstein, RN | 1 |
| Wang, Z | 1 |
| Sadée, W | 1 |
| Porreca, F | 1 |
| Cruz, SL | 1 |
| Villarreal, JE | 1 |
| Volkow, ND | 1 |
| Zhu, H | 1 |
| Feng, YZ | 1 |
| Fan, GH | 1 |
| Wang, LZ | 1 |
| Qiu, HC | 1 |
| Ma, L | 1 |
| Pei, G | 1 |
| Lu, L | 1 |
| Zeng, S | 1 |
| Liu, D | 1 |
| Ceng, X | 1 |
6 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Morphine Abuse
| Article | Year |
|---|---|
Possible involvement of protein kinases in physical dependence on opioids: studies using protein kinase inhibitors, H-7 and H-8.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Behavior, Animal; Butorphanol; Cytosol; Enzy | 1995 |
Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Analgesics, Opioid; Animals; Dru | 1996 |
Further evidence that naloxone acts as an inverse opiate agonist: implications for drug dependence and withdrawal.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Iso | 1996 |
The role of glutamate in the locus coeruleus during opioid withdrawal and effects of H-7, a protein kinase inhibitor, on the action of glutamate in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Butorphanol; Glutamic Acid; Infusions, Paren | 1998 |
Inhibition of calcium/calmodulin-dependent protein kinase II in rat hippocampus attenuates morphine tolerance and dependence.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium-Calmodulin-Dependent P | 1999 |
Inhibition of the amygdala and hippocampal calcium/calmodulin-dependent protein kinase II attenuates the dependence and relapse to morphine differently in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amygdala; Animals; Behavior, Animal; Calcium-Calmodul | 2000 |