1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Melanoma in 7 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In human melanoma cells, the combination of mezerein (MEZ) and fibroblast interferon (IFN-beta), results in a rapid and irreversible suppression of cell growth with a concomitant increase in the synthesis of melanin." | 3.68 | Modulation of the antigenic phenotype of human melanoma cells by differentiation-inducing and growth-suppressing agents. ( Ferrone, S; Fisher, PB; Graham, GM; Guarini, L; Jiang, H; Zucker, S, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nishida, S | 1 |
| Yoshioka, S | 1 |
| Kinoshita-Kimoto, S | 1 |
| Kotani, M | 1 |
| Tsubaki, M | 1 |
| Fujii, Y | 1 |
| Tomura, TT | 1 |
| Irimajiri, K | 1 |
| White, N | 1 |
| Butler, PE | 1 |
| Burnstock, G | 1 |
| Nordenberg, J | 1 |
| Goldwasser, I | 1 |
| Zoref-Shani, E | 1 |
| Beery, E | 1 |
| Sidi, Y | 1 |
| Guarini, L | 1 |
| Graham, GM | 1 |
| Jiang, H | 1 |
| Ferrone, S | 1 |
| Zucker, S | 1 |
| Fisher, PB | 1 |
| Johnson, SE | 1 |
| Baglioni, C | 1 |
| Becker, D | 1 |
| Beebe, SJ | 1 |
| Herlyn, M | 1 |
| Preston, SF | 1 |
| Volpi, M | 1 |
| Pearson, CM | 1 |
| Berlin, RD | 1 |
7 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Melanoma
| Article | Year |
|---|---|
Pretreatment with PKC inhibitor triggers TNF-alpha induced apoptosis in TNF-alpha-resistant B16 melanoma BL6 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antineoplastic Agents; Apoptosis; Butadienes | 2003 |
Human melanomas express functional P2 X(7) receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Apoptosis; Caspase 3; Caspase | 2005 |
Inhibition of B16 melanoma cell proliferation and alterations in p21 ras expression induced by interceptors of signal transduction pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Agents; Cell Division; Drug Screening | 1996 |
Modulation of the antigenic phenotype of human melanoma cells by differentiation-inducing and growth-suppressing agents.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Neoplasm; Cell Adhesion Molecules; Cell Dif | 1992 |
Positive and negative regulation of a tumor necrosis factor response in melanoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; DNA Probes; Female; Humans; Isoqu | 1990 |
Differential expression of protein kinase C and cAMP-dependent protein kinase in normal human melanocytes and malignant melanomas.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Blotting, Southern; Cell Division | 1990 |
Regulation of cell shape in the Cloudman melanoma cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-MSH; Animals; Axons; Cell Line; Cyclic AMP; Cyc | 1987 |