1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Malignant Melanoma in 7 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In human melanoma cells, the combination of mezerein (MEZ) and fibroblast interferon (IFN-beta), results in a rapid and irreversible suppression of cell growth with a concomitant increase in the synthesis of melanin." | 3.68 | Modulation of the antigenic phenotype of human melanoma cells by differentiation-inducing and growth-suppressing agents. ( Ferrone, S; Fisher, PB; Graham, GM; Guarini, L; Jiang, H; Zucker, S, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nishida, S | 1 |
| Yoshioka, S | 1 |
| Kinoshita-Kimoto, S | 1 |
| Kotani, M | 1 |
| Tsubaki, M | 1 |
| Fujii, Y | 1 |
| Tomura, TT | 1 |
| Irimajiri, K | 1 |
| White, N | 1 |
| Butler, PE | 1 |
| Burnstock, G | 1 |
| Nordenberg, J | 1 |
| Goldwasser, I | 1 |
| Zoref-Shani, E | 1 |
| Beery, E | 1 |
| Sidi, Y | 1 |
| Guarini, L | 1 |
| Graham, GM | 1 |
| Jiang, H | 1 |
| Ferrone, S | 1 |
| Zucker, S | 1 |
| Fisher, PB | 1 |
| Johnson, SE | 1 |
| Baglioni, C | 1 |
| Becker, D | 1 |
| Beebe, SJ | 1 |
| Herlyn, M | 1 |
| Preston, SF | 1 |
| Volpi, M | 1 |
| Pearson, CM | 1 |
| Berlin, RD | 1 |
7 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Malignant Melanoma
| Article | Year |
|---|---|
Pretreatment with PKC inhibitor triggers TNF-alpha induced apoptosis in TNF-alpha-resistant B16 melanoma BL6 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antineoplastic Agents; Apoptosis; Butadienes | 2003 |
Human melanomas express functional P2 X(7) receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Apoptosis; Caspase 3; Caspase | 2005 |
Inhibition of B16 melanoma cell proliferation and alterations in p21 ras expression induced by interceptors of signal transduction pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Agents; Cell Division; Drug Screening | 1996 |
Modulation of the antigenic phenotype of human melanoma cells by differentiation-inducing and growth-suppressing agents.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Neoplasm; Cell Adhesion Molecules; Cell Dif | 1992 |
Positive and negative regulation of a tumor necrosis factor response in melanoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; DNA Probes; Female; Humans; Isoqu | 1990 |
Differential expression of protein kinase C and cAMP-dependent protein kinase in normal human melanocytes and malignant melanomas.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Blotting, Southern; Cell Division | 1990 |
Regulation of cell shape in the Cloudman melanoma cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-MSH; Animals; Axons; Cell Line; Cyclic AMP; Cyc | 1987 |