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1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Liver Cirrhosis, Biliary

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Liver Cirrhosis, Biliary in 1 studies

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.

Liver Cirrhosis, Biliary: FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cholangitis involves the destruction of small intra-hepatic bile ducts and decreased bile secretion. Secondary biliary cholangitis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.

Research Excerpts

ExcerptRelevanceReference
"These results show in secondary biliary cirrhosis that (1) Rho-kinase activation with resultant eNOS down-regulation is substantially involved in the pathogenesis of portal hypertension and (2) Rho-kinase might interact with Akt and subsequently inhibit the binding of Akt to eNOS."1.35Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis. ( Anegawa, G; Hashizume, M; Kawanaka, H; Kinjo, N; Konishi, K; Maehara, Y; Shimokawa, H; Taketomi, A; Yamaguchi, S; Yoshida, D, 2008)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Anegawa, G1
Kawanaka, H1
Yoshida, D1
Konishi, K1
Yamaguchi, S1
Kinjo, N1
Taketomi, A1
Hashizume, M1
Shimokawa, H1
Maehara, Y1

Other Studies

1 other study available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Liver Cirrhosis, Biliary

ArticleYear
Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis.
    Hepatology (Baltimore, Md.), 2008, Volume: 47, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Aorta; Disease Models, Animal; Hemod

2008