1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Leukemia in 7 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a previous study, we showed that geranylgeraniol (GGO) is a potent inducer of apoptosis in human leukemia cells, including HL60 promyelocytic leukemia cells." | 7.69 | Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells. ( Aiuchi, T; Masuda, Y; Nakajo, S; Nakaya, K; Ohizumi, H; Watabe, M; Yoda, M, 1997) |
| "In a previous study, we showed that geranylgeraniol (GGO) is a potent inducer of apoptosis in human leukemia cells, including HL60 promyelocytic leukemia cells." | 3.69 | Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells. ( Aiuchi, T; Masuda, Y; Nakajo, S; Nakaya, K; Ohizumi, H; Watabe, M; Yoda, M, 1997) |
| "Injected human leukemic and breast cancer cells exhibited cell-type specific patterns of intravascular distribution with leukemic cells moving faster than breast cancer cells." | 1.56 | Long-term in vivo imaging reveals tumor-specific dissemination and captures host tumor interaction in zebrafish xenografts. ( Asokan, N; Bernas, SN; Bornhäuser, M; Brand, M; Daetwyler, S; Huisken, J; Kempermann, G; Lambert, K; Schmied, C; Vogler, S; Wermke, M; Wobus, M, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Asokan, N | 1 |
| Daetwyler, S | 1 |
| Bernas, SN | 1 |
| Schmied, C | 1 |
| Vogler, S | 1 |
| Lambert, K | 1 |
| Wobus, M | 1 |
| Wermke, M | 1 |
| Kempermann, G | 1 |
| Huisken, J | 1 |
| Brand, M | 1 |
| Bornhäuser, M | 1 |
| Zhang, X | 1 |
| Meng, L | 1 |
| He, B | 1 |
| Chen, J | 1 |
| Liu, P | 1 |
| Zhao, J | 1 |
| Zhang, Y | 1 |
| Li, M | 1 |
| An, D | 1 |
| Jung, EY | 1 |
| Ohshima, Y | 1 |
| Shintaku, N | 1 |
| Sumimoto, S | 1 |
| Heike, T | 1 |
| Katamura, K | 1 |
| Mayumi, M | 1 |
| Masuda, Y | 1 |
| Yoda, M | 1 |
| Ohizumi, H | 1 |
| Aiuchi, T | 1 |
| Watabe, M | 1 |
| Nakajo, S | 1 |
| Nakaya, K | 1 |
| Koike, T | 1 |
| Harada, N | 1 |
| Yoshida, T | 1 |
| Morikawa, M | 1 |
| Meichle, A | 1 |
| Schütze, S | 1 |
| Hensel, G | 1 |
| Brunsing, D | 1 |
| Krönke, M | 1 |
| Spisani, S | 1 |
| Gavioli, R | 1 |
| Giuliani, AL | 1 |
| Traniello, S | 1 |
7 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Leukemia
| Article | Year |
|---|---|
Long-term in vivo imaging reveals tumor-specific dissemination and captures host tumor interaction in zebrafish xenografts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Tra | 2020 |
The role of P2X7 receptor in ATP-mediated human leukemia cell death: calcium influx-independent.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Apoptosis; Benzoxazoles; Biol | 2009 |
Effects of cyclic AMP on expression of LFA-1, Mac-1, and VLA-4 and eosinophilic differentiation of a human leukemia cell line, EoL-1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, CD; Bucladesine; Butyrates; Cell Differenti | 1994 |
Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Apoptosis; Diglycerides; Diterpen | 1997 |
Regulation of myeloid-specific calcium binding protein synthesis by cytosolic protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Calcitriol; Calcium-Bind | 1992 |
Protein kinase C-independent activation of nuclear factor kappa B by tumor necrosis factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Binding Sites; Cell Line; D | 1990 |
Triggering of neutrophil cytotoxicity against an antibody-coated tumour target by TPA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antibody-Dependent Cell Cytot | 1989 |