1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Leukemia, Promyelocytic, Acute in 12 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Leukemia, Promyelocytic, Acute: An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 10 (83.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jarvis, WD | 1 |
| Turner, AJ | 1 |
| Povirk, LF | 1 |
| Traylor, RS | 1 |
| Grant, S | 1 |
| Walters, JD | 1 |
| Wojcik, MS | 1 |
| Bertrand, R | 1 |
| Solary, E | 1 |
| Jenkins, J | 1 |
| Pommier, Y | 1 |
| Taoka, T | 1 |
| Yamaoka, G | 1 |
| Arai, T | 1 |
| Kiuchi, H | 1 |
| Tanaka, T | 1 |
| Takahara, J | 1 |
| Kawanishi, K | 1 |
| Irino, S | 1 |
| Pérez-Sala, D | 1 |
| Collado-Escobar, D | 1 |
| Mollinedo, F | 1 |
| Zimber, A | 1 |
| Chedeville, A | 1 |
| Gespach, C | 1 |
| Abita, JP | 1 |
| Kharbanda, S | 1 |
| Datta, R | 1 |
| Kufe, D | 1 |
| Xun, CQ | 1 |
| Tian, ZG | 1 |
| Tai, HH | 1 |
| Staats, J | 1 |
| Marquardt, D | 1 |
| Center, MS | 1 |
| Hurme, M | 1 |
| Serkkola, E | 1 |
| Ronni, T | 1 |
| Silvennoinen, O | 1 |
| Simpson, RU | 1 |
| Hsu, T | 1 |
| Wendt, MD | 1 |
| Taylor, JM | 1 |
| Uemura, Y | 1 |
| Nishikawa, M | 1 |
| Komada, F | 1 |
| Shirakawa, S | 1 |
12 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Leukemia, Promyelocytic, Acute
| Article | Year |
|---|---|
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Anthracenes; Antineoplastic Agents; Apopto | 1994 |
Polyamine transport in human promyelocytic leukemia cells and polymorphonuclear leukocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Transport; Cell Line; Genistein; Gramicidi | 1994 |
Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Aphidicolin; Apoptosis; B | 1993 |
Alkaline phosphatase activity in the human promyelocytic leukemia cell line, HL-60, induced by retinoic acid and recombinant human granulocyte colony-stimulating factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaline Phosphatase; Alkaloids; Calcitriol; Cell Lin | 1993 |
Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Apoptosis; Cell Cycle; Cell Line; Cyclohex | 1995 |
Inhibition of proliferation and induction of monocytic differentiation on HL60 human promyelocytic leukemia cells treated with bile acids in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bile Acids and Salts; Cell Cycle; Cell Differentiatio | 1994 |
Regulation of c-jun gene expression in HL-60 leukemia cells by 1-beta-D-arabinofuranosylcytosine. Potential involvement of a protein kinase C dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aphidicolin; Cell Line; Cell Nucleus; Cycloheximide; | 1991 |
Stimulation of synthesis de novo of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase in human promyelocytic leukaemia (HL-60) cells by phorbol ester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Western; Dimethyl Sulfoxide; Din | 1991 |
Characterization of a membrane-associated protein kinase of multidrug-resistant HL60 cells which phosphorylates P-glycoprotein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Amino Acids; ATP Binding Cassett | 1990 |
Control of interleukin-1 beta expression by protein kinase C and cyclic adenosine monophosphate in myeloid leukemia cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bucladesine; Colforsin; Cyclic AMP; Dinoprostone; Enz | 1990 |
1,25-Dihydroxyvitamin D3 regulation of c-myc protooncogene transcription. Possible involvement of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcitriol; Cell Differentiation; Cell Line; Cell Nuc | 1989 |
Alteration of intracellular actin levels induced by phorboldiester in human HL-60 leukemia cells susceptible or resistant to differentiation, and the effects of protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Antibodies, Monoclonal; Antigen-An | 1989 |