1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Leukemia, Myeloid, Acute in 10 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (70.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wermke, M | 1 |
| Camgoz, A | 1 |
| Paszkowski-Rogacz, M | 1 |
| Thieme, S | 1 |
| von Bonin, M | 1 |
| Dahl, A | 1 |
| Platzbecker, U | 1 |
| Theis, M | 1 |
| Ehninger, G | 1 |
| Brenner, S | 1 |
| Bornhäuser, M | 1 |
| Buchholz, F | 1 |
| Wang, W | 1 |
| Xiao, J | 1 |
| Adachi, M | 1 |
| Liu, Z | 1 |
| Zhou, J | 1 |
| Adachi, S | 1 |
| Kubota, M | 1 |
| Lin, YW | 1 |
| Okuda, A | 1 |
| Matsubara, K | 1 |
| Wakazono, Y | 1 |
| Hirota, H | 1 |
| Kuwakado, K | 1 |
| Akiyama, Y | 1 |
| Ina, Y | 1 |
| Koide, Y | 1 |
| Nezu, N | 1 |
| Yoshida, TO | 1 |
| Chapekar, MS | 1 |
| Hartman, KD | 1 |
| Knode, MC | 1 |
| Glazer, RI | 1 |
| Homma, Y | 1 |
| Gemmell, MA | 1 |
| Huberman, E | 1 |
| Nozawa, R | 1 |
| Kato, H | 1 |
| Yokota, T | 1 |
| Martell, RE | 1 |
| Simpson, RU | 1 |
| Hsu, T | 1 |
| Nishikawa, M | 1 |
| Uemura, Y | 1 |
| Hidaka, H | 1 |
| Shirakawa, S | 1 |
| May, WS | 1 |
| Tyler, G | 1 |
1 trial available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
In vivo administration of granulocyte colony-stimulating factor promotes neutrophil survival in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adolescent; Burkitt Lymphoma; Cell Survival; Child; C | 1994 |
9 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
RNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates fasudil as an antileukemic drug.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Agents; Apoptosis; Female; Humans; Leu | 2015 |
4-aminopyridine induces apoptosis of human acute myeloid leukemia cells via increasing [Ca2+]i through P2X7 receptor pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Apoptosis; Calcium; Calcium Channels | 2011 |
Regulation of HLA class II antigen expression: intracellular signaling molecules responsible for the regulation by IFN-gamma and cross-linking of Fc receptors in HL-60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Neoplasm; Calcimycin; Calcium; Calmodulin; | 1987 |
Synergistic effect of retinoic acid and calcium ionophore A23187 on differentiation, c-myc expression, and membrane tyrosine kinase activity in human promyelocytic leukemia cell line HL-60.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Calmodulin; Cell Differentiation; Cell Li | 1987 |
Protein kinase C activities with different characteristics, including substrate specificity, from two human HL-60 leukemia cell variants.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Humans; Isoquinolines; Leukemia, Myeloid, Ac | 1988 |
Induction of cytosolic activation factor for NADPH oxidase in differentiated HL-60 leukemia cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcitriol; Calcium; Cell Differentiation; Cytosol; E | 1988 |
Effects of protein kinase inhibitors 1(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and N-[2-guanidinoethyl]-5-isoquinolinesulfonamide hydrochloride (HA1004) on calcitriol-induced differentiation of HL-60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcitriol; Cell Differentiation; Cell Survival; DNA, | 1988 |
1-(5-Isoquinolinesulfonyl)-2-methylpiperazine(H-7), a potent inhibitor of protein kinases, inhibits the differentiation of HL-60 cells induced by phorbol diester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Differentiation; Cell Division; Cell Line; Depre | 1986 |
Phosphorylation of the surface transferrin receptor stimulates receptor internalization in HL60 leukemic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Exocytosis; Humans; Isoquinolines; Leukemi | 1987 |