1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 5 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burthem, J | 1 |
| Rees-Unwin, K | 1 |
| Mottram, R | 1 |
| Adams, J | 1 |
| Lucas, GS | 1 |
| Spooncer, E | 1 |
| Whetton, AD | 1 |
| Motyl, T | 1 |
| Kasterka, M | 1 |
| Grzelkowska, K | 1 |
| Blachowski, S | 1 |
| Sysa, P | 1 |
| Ezawa, H | 1 |
| Harigaya, K | 1 |
| Ishii, G | 1 |
| Nakajima, N | 1 |
| Mikata, A | 1 |
| Huang, CC | 1 |
| Chang, CB | 1 |
| Liu, JY | 1 |
| Basavappa, S | 1 |
| Lim, PH | 1 |
| Takemura, Y | 1 |
| Koide, Y | 1 |
| Miyachi, H | 1 |
| Shibata, T | 1 |
| Sekiguchi, S | 1 |
| Tukemura, Y | 1 |
5 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Antigens, CD34; Benzamides; Cell Proliferatio | 2007 |
TGF-beta 1 inhibits polyamine biosynthesis in K 562 leukemic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosylmethionine Decarboxylase; Apoptosis; Cell Div | 1993 |
12-O-tetradecanoylphorbol-13-acetate (TPA) downregulates expression of CD30 in erythroleukemia cell line K562.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Neoplasm; Blast Crisis; Cycloheximide; Dact | 1997 |
Effects of calcium, calmodulin, protein kinase C and protein tyrosine kinases on volume-activated taurine efflux in human erythroleukemia cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Transport; Calcium; Calcium Channel Blocke | 2001 |
Effect of verapamil on the class I major histocompatibility complex antigen expression in K562 chronic myelogenous leukemia cells treated with recombinant human interferon-gamma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Blotting, Northern; Calcimyci | 1992 |