1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Leukemia, Megakaryoblastic, Acute in 6 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Leukemia, Megakaryoblastic, Acute: An acute myeloid leukemia in which 20-30% of the bone marrow or peripheral blood cells are of megakaryocyte lineage. MYELOFIBROSIS or increased bone marrow RETICULIN is common.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute megakaryocytic leukemia (AMKL) is a rare neoplasm caused by abnormal megakaryoblasts." | 1.91 | Fasudil promotes polyploidization of megakaryoblasts in an acute megakaryocyte leukemia model. ( Gao, Y; He, B; Niu, J; Wang, C; Wang, F; Yang, Q; Zhang, Y, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| He, B | 1 |
| Wang, C | 1 |
| Niu, J | 1 |
| Wang, F | 1 |
| Zhang, Y | 1 |
| Gao, Y | 1 |
| Yang, Q | 1 |
| Wen, Q | 2 |
| Goldenson, B | 1 |
| Silver, SJ | 1 |
| Schenone, M | 1 |
| Dancik, V | 1 |
| Huang, Z | 1 |
| Wang, LZ | 1 |
| Lewis, TA | 1 |
| An, WF | 1 |
| Li, X | 1 |
| Bray, MA | 1 |
| Thiollier, C | 2 |
| Diebold, L | 1 |
| Gilles, L | 1 |
| Vokes, MS | 1 |
| Moore, CB | 1 |
| Bliss-Moreau, M | 1 |
| Verplank, L | 1 |
| Tolliday, NJ | 1 |
| Mishra, R | 1 |
| Vemula, S | 1 |
| Shi, J | 1 |
| Wei, L | 1 |
| Kapur, R | 1 |
| Lopez, CK | 2 |
| Gerby, B | 2 |
| Ballerini, P | 2 |
| Pflumio, F | 2 |
| Gilliland, DG | 1 |
| Goldberg, L | 1 |
| Birger, Y | 1 |
| Izraeli, S | 1 |
| Gamis, AS | 1 |
| Smith, FO | 1 |
| Woods, WG | 1 |
| Taub, J | 1 |
| Scherer, CA | 1 |
| Bradner, JE | 1 |
| Goh, BC | 1 |
| Mercher, T | 2 |
| Carpenter, AE | 1 |
| Gould, RJ | 1 |
| Clemons, PA | 1 |
| Carr, SA | 1 |
| Root, DE | 1 |
| Schreiber, SL | 1 |
| Stern, AM | 1 |
| Crispino, JD | 2 |
| Ignacimouttou, C | 1 |
| Poglio, S | 1 |
| Duffourd, Y | 1 |
| Guégan, J | 1 |
| Rivera-Munoz, P | 1 |
| Bluteau, O | 1 |
| Mabialah, V | 1 |
| Diop, M | 1 |
| Petit, A | 1 |
| Bauchet, AL | 1 |
| Reinhardt, D | 1 |
| Bornhauser, B | 1 |
| Gautheret, D | 1 |
| Lecluse, Y | 1 |
| Landman-Parker, J | 1 |
| Radford, I | 1 |
| Vainchenker, W | 1 |
| Dastugue, N | 1 |
| de Botton, S | 1 |
| Dessen, P | 1 |
| Bourquin, JP | 1 |
| Bernard, OA | 1 |
| Rajotte, D | 1 |
| Haddad, P | 1 |
| Haman, A | 1 |
| Cragoe, EJ | 1 |
| Hoang, T | 1 |
| Goto, S | 1 |
| Kobayashi, M | 1 |
| Hidaka, H | 2 |
| Saito, H | 2 |
| Ito, T | 1 |
| Kozawa, O | 1 |
6 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Leukemia, Megakaryoblastic, Acute
| Article | Year |
|---|---|
Fasudil promotes polyploidization of megakaryoblasts in an acute megakaryocyte leukemia model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Leukemia, Megakaryoblastic, Acute; Megakaryo | 2023 |
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aurora Kinase A; Aurora Kinases; Azepines; C | 2012 |
Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Amino Acid Sequence; Animals; Aurora Kinase A; | 2012 |
Role of protein kinase C and the Na+/H+ antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amiloride; Carrier Proteins; Cell Death; C | 1992 |
[Shape change in human megakaryoblastic leukemia cells, MEG-01].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Calcimycin; Humans; Isoquinolines | 1992 |
Thrombin-induced translocation of protein kinase C in human megakaryoblastic leukemia cells (MEG-01).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Transport; Calcium; Cell Membrane; Cytosol | 1991 |