Page last updated: 2024-10-28

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Ischemic Stroke

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Ischemic Stroke in 2 studies

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.

Ischemic Stroke: Stroke due to BRAIN ISCHEMIA resulting in interruption or reduction of blood flow to a part of the brain. When obstruction is due to a BLOOD CLOT formed within in a cerebral blood vessel it is a thrombotic stroke. When obstruction is formed elsewhere and moved to block a cerebral blood vessel (see CEREBRAL EMBOLISM) it is referred to as embolic stroke. Wake-up stroke refers to ischemic stroke occurring during sleep while cryptogenic stroke refers to ischemic stroke of unknown origin.

Research Excerpts

ExcerptRelevanceReference
" Additionally, our previous studies reported that combination therapy with liposomal fasudil plus tissue plasminogen activator (t-PA), a thrombolytic agent, brings about decrease in the risk of t-PA-derived cerebral hemorrhage and prolong the therapeutic time window of t-PA for treating acute ischemic stroke."5.12[Development of Biomembrane-mimetic Nanoparticles for the Treatment of Ischemic Stroke]. ( Fukuta, T, 2021)
"Our findings suggest that fasudil is a BBB-protective agent against acute ischemic stroke."4.12Effects of fasudil on blood-brain barrier integrity. ( Deli, MA; Fujimoto, T; Izumo, T; Matsunaga, Y; Matsuo, T; Morofuji, Y; Nakagawa, S; Niwa, M; Santa-Maria, AR; Sato, K; Vigh, JP; Walter, FR; Watanabe, D, 2022)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's2 (100.00)2.80

Authors

AuthorsStudies
Fukuta, T1
Sato, K1
Nakagawa, S1
Morofuji, Y1
Matsunaga, Y1
Fujimoto, T1
Watanabe, D1
Izumo, T1
Niwa, M1
Walter, FR1
Vigh, JP1
Santa-Maria, AR1
Deli, MA1
Matsuo, T1

Reviews

1 review available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Ischemic Stroke

ArticleYear
[Development of Biomembrane-mimetic Nanoparticles for the Treatment of Ischemic Stroke].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2021, Volume: 141, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood-Brain Barrier; Capillary Permeability;

2021

Other Studies

1 other study available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Ischemic Stroke

ArticleYear
Effects of fasudil on blood-brain barrier integrity.
    Fluids and barriers of the CNS, 2022, Jun-03, Volume: 19, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13

2022