1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Intraocular Pressure in 12 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Intraocular Pressure: The pressure of the fluids in the eye.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In addition, in the rabbit ocular hypertension model, the topical administration of H-1152P (28 mM) significantly lowered IOPs starting at 30 minutes and lasting up to 300 minutes after water loading." | 1.35 | The effect of the H-1152P, a potent Rho-associated coiled coil-formed protein kinase inhibitor, in rabbit normal and ocular hypertensive eyes. ( Fukunaga, T; Hidaka, H; Ikesugi, K; Nishio, M; Sugimoto, M; Sumi, K; Uji, Y, 2009) |
| " Multiple daily dosing with the drug produced a persistent IOP-lowering effect." | 1.35 | Evaluation of monkey intraocular pressure by rebound tonometer. ( Cao, G; Chen, L; Li, N; Liu, X; Ma, J; Pang, IH; Qiu, J; Yan, N; Yu, M; Yu, W, 2009) |
| " Higher baseline IOP and repeated dosing were associated with greater IOP reduction." | 1.32 | Effects of topical H-7 on outflow facility, intraocular pressure, and corneal thickness in monkeys. ( Kaufman, PL; Podos, SM; Tian, B; Wang, RF, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 10 (83.33) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, M | 2 |
| Chen, X | 1 |
| Wang, N | 1 |
| Cai, S | 1 |
| Li, N | 2 |
| Qiu, J | 2 |
| Brandt, CR | 1 |
| Kaufman, PL | 6 |
| Liu, X | 2 |
| Fukunaga, T | 2 |
| Ikesugi, K | 2 |
| Nishio, M | 2 |
| Sugimoto, M | 2 |
| Sasoh, M | 1 |
| Hidaka, H | 2 |
| Uji, Y | 2 |
| Sumi, K | 1 |
| Yu, W | 1 |
| Cao, G | 1 |
| Ma, J | 1 |
| Yan, N | 1 |
| Chen, L | 1 |
| Pang, IH | 1 |
| Sugiyama, T | 1 |
| Shibata, M | 1 |
| Kajiura, S | 1 |
| Okuno, T | 1 |
| Tonari, M | 1 |
| Oku, H | 1 |
| Ikeda, T | 1 |
| Bahler, CK | 1 |
| Hann, CR | 1 |
| Fautsch, MP | 1 |
| Johnson, DH | 1 |
| Gabelt, BT | 4 |
| Hennes, EA | 1 |
| Seeman, JL | 1 |
| Tian, B | 4 |
| Wang, RF | 1 |
| Podos, SM | 1 |
| Hu, Y | 1 |
| Volberg, T | 1 |
| Geiger, B | 2 |
| Sabanay, I | 1 |
| Honjo, M | 1 |
| Inatani, M | 1 |
| Kido, N | 1 |
| Sawamura, T | 1 |
| Yue, BY | 1 |
| Honda, Y | 1 |
| Tanihara, H | 1 |
12 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Intraocular Pressure
| Article | Year |
|---|---|
H-1152 effects on intraocular pressure and trabecular meshwork morphology of rat eyes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Cells, Cultured; Eye; Humans; Int | 2008 |
The effect of the Rho-associated protein kinase inhibitor, HA-1077, in the rabbit ocular hypertension model induced by water loading.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Topical; Animals; Disease Models, Ani | 2009 |
The effect of the H-1152P, a potent Rho-associated coiled coil-formed protein kinase inhibitor, in rabbit normal and ocular hypertensive eyes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Topical; Animals; Conjunctiva; Dose-R | 2009 |
Evaluation of monkey intraocular pressure by rebound tonometer.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Topical; Animals; Antihypertensive Ag | 2009 |
Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Topical; Animals; Blood Flow Velocity | 2011 |
Pharmacologic disruption of Schlemm's canal cells and outflow facility in anterior segments of human eyes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Aged, 80 and over; Aqueous Humor; Cell S | 2004 |
H-7 effect on outflow facility after trabecular obstruction following long-term echothiophate treatment in monkeys.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Accommodation, Ocular; Animals; Aqueous Humor; Cholin | 2004 |
Effects of topical H-7 on outflow facility, intraocular pressure, and corneal thickness in monkeys.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Topical; Animals; Aqueous Humor; Corn | 2004 |
Monkey organ-cultured anterior segments: technique and response to H-7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anterior Eye Segment; Enzyme Inhibitors; Fem | 2006 |
H-7 disrupts the actin cytoskeleton and increases outflow facility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Administration, Topical; Animals; Aorta; Aque | 1998 |
H-7 effects on the structure and fluid conductance of monkey trabecular meshwork.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anterior Chamber; Aqueous Humor; Cytoskeleta | 2000 |
Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Aqueous Humor; Blotting, Western; Ca | 2001 |