1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Intracranial Arteriovenous Malformations in 2 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Intracranial Arteriovenous Malformations: Congenital vascular anomalies in the brain characterized by direct communication between an artery and a vein without passing through the CAPILLARIES. The locations and size of the shunts determine the symptoms including HEADACHES; SEIZURES; STROKE; INTRACRANIAL HEMORRHAGES; mass effect; and vascular steal effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil-treated Ccm1(+/-)Msh2(-/-) mice had a significantly decreased prevalence of CCM lesions compared with placebo controls." | 1.38 | Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. ( Awad, IA; Ginsberg, MH; Liu, F; Marchuk, DA; McDonald, DA; Shenkar, R; Shi, C; Stockton, RA, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gross, BA | 1 |
| Albuquerque, FC | 1 |
| McDonald, DA | 1 |
| Shi, C | 1 |
| Shenkar, R | 1 |
| Stockton, RA | 1 |
| Liu, F | 1 |
| Ginsberg, MH | 1 |
| Marchuk, DA | 1 |
| Awad, IA | 1 |
2 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Intracranial Arteriovenous Malformations
| Article | Year |
|---|---|
Endothelial-mesenchymal transition in cerebral cavernous malformations and the unveiling of new potential therapeutic targets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Enzyme Inhibitors; Intracranial Arteriovenou | 2014 |
Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Cerebral Hemorrhage; Enzyme Inhibitor | 2012 |