1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Intellectual Disability in 3 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
| Excerpt | Relevance | Reference |
|---|
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Busti, I | 1 |
| Allegra, M | 1 |
| Spalletti, C | 1 |
| Panzi, C | 1 |
| Restani, L | 1 |
| Billuart, P | 2 |
| Caleo, M | 1 |
| Martin Lorenzo, S | 1 |
| Nalesso, V | 1 |
| Chevalier, C | 1 |
| Birling, MC | 1 |
| Herault, Y | 2 |
| Meziane, H | 1 |
| Khelfaoui, M | 1 |
| Morello, N | 1 |
| Hiba, B | 1 |
| Calcagno, E | 1 |
| Reibel-Foisset, S | 1 |
| Selloum, M | 1 |
| Chelly, J | 1 |
| Humeau, Y | 1 |
| Riet, F | 1 |
| Zanni, G | 1 |
| Bienvenu, T | 1 |
| Giustetto, M | 1 |
3 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Intellectual Disability
| Article | Year |
|---|---|
ROCK/PKA Inhibition Rescues Hippocampal Hyperexcitability and GABAergic Neuron Alterations in a Oligophrenin-1 Knock-Out Mouse Model of X-Linked Intellectual Disability.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cyclic AMP-Dependent Protein Kinases; Cytosk | 2020 |
Targeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alleles; Animals; Autism Spectrum Disorder; Autistic | 2021 |
Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Animals; Autism Spectrum Disorder; Behavior, A | 2016 |