1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Injury, Myocardial Reperfusion in 20 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study aimed to determine the protective effect of fasudil pretreatment combined with IPO on myocardial ischemia/reperfusion injury in rats and explore the possible mechanisms." | 7.80 | The protective effect of fasudil pretreatment combined with ischemia postconditioning on myocardial ischemia/reperfusion injury in rats. ( Guan, YE; Jia, DL; Li, WN; Shu, WQ; Wu, N, 2014) |
| "The current study was carried out to determine whether fasudil hydrochloride (fasudil), a Rho-kinase inhibitor, has myocardial postconditioning (PostC) activity under hyperglycemia as well as normoglycemia, and if so, whether the effects could be mediated by mitochondrial ATP-sensitive potassium (m-KATP) channels." | 7.78 | High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels. ( Cho, S; Higashijima, U; Ichinomiya, T; Maekawa, T; Matsumoto, S; Sumikawa, K, 2012) |
| "Fasudil may induce preconditioning and postconditioning against myocardial ischemia‑reperfusion injury in normal rats, however, their effectivenesses in hypercholesterolemia remains to be determined." | 3.80 | High‑dose fasudil preconditioning and postconditioning attenuate myocardial ischemia‑reperfusion injury in hypercholesterolemic rats. ( Jia, D; Wu, N; Zhang, X, 2014) |
| " This study aimed to determine the protective effect of fasudil pretreatment combined with IPO on myocardial ischemia/reperfusion injury in rats and explore the possible mechanisms." | 3.80 | The protective effect of fasudil pretreatment combined with ischemia postconditioning on myocardial ischemia/reperfusion injury in rats. ( Guan, YE; Jia, DL; Li, WN; Shu, WQ; Wu, N, 2014) |
| "The current study was carried out to determine whether fasudil hydrochloride (fasudil), a Rho-kinase inhibitor, has myocardial postconditioning (PostC) activity under hyperglycemia as well as normoglycemia, and if so, whether the effects could be mediated by mitochondrial ATP-sensitive potassium (m-KATP) channels." | 3.78 | High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels. ( Cho, S; Higashijima, U; Ichinomiya, T; Maekawa, T; Matsumoto, S; Sumikawa, K, 2012) |
| "Fasudil treatment for inhibiting Rho kinase promoted autophagy in ex vivo rat heart to protect against myocardial ischima-reperfusion injury possibly by reducing apoptosis of the cardiac myocytes." | 1.43 | [Role of autophagy in fasudil-induced Rho kinase inhibition for protection against myocardial ischemia-reperfusion injury in rats]. ( Fang, TT; Gao, Q; Gu, XY; Wang, Y; Ye, HW; Yu, Y; Zhu, GY, 2016) |
| "Fasudil was administered 15 min prior to ischemia, and wortmannin and L‑NAME were administered following IPoC." | 1.40 | Inhibition of Rho-kinase by fasudil restores the cardioprotection of ischemic postconditioninng in hypercholesterolemic rat heart. ( Jia, D; Li, W; Lv, Y; Shu, W; Wu, N, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 13 (65.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, Z | 1 |
| Qiu, B | 1 |
| Wang, Q | 1 |
| Wei, W | 1 |
| Huang, J | 1 |
| Duan, W | 1 |
| Miyahara, S | 1 |
| Jenke, A | 1 |
| Yazdanyar, M | 1 |
| Kistner, J | 1 |
| Immohr, MB | 1 |
| Sugimura, Y | 1 |
| Aubin, H | 1 |
| Kamiya, H | 1 |
| Okita, Y | 1 |
| Lichtenberg, A | 1 |
| Akhyari, P | 1 |
| Ye, H | 1 |
| Zhang, G | 1 |
| Cao, R | 1 |
| Kang, P | 1 |
| Li, Z | 1 |
| Gao, Q | 2 |
| Kong, LH | 1 |
| Gu, XM | 1 |
| Wu, F | 1 |
| Jin, ZX | 1 |
| Zhou, JJ | 1 |
| Jiang, ZH | 1 |
| Zhang, TT | 1 |
| Zhang, JF | 1 |
| Wu, N | 4 |
| Zhang, X | 1 |
| Jia, D | 3 |
| Kitano, K | 1 |
| Usui, S | 1 |
| Ootsuji, H | 1 |
| Takashima, S | 1 |
| Kobayashi, D | 1 |
| Murai, H | 1 |
| Furusho, H | 1 |
| Nomura, A | 1 |
| Kaneko, S | 1 |
| Takamura, M | 1 |
| Kiss, A | 2 |
| Tratsiakovich, Y | 2 |
| Gonon, AT | 2 |
| Fedotovskaya, O | 1 |
| Lanner, JT | 1 |
| Andersson, DC | 1 |
| Yang, J | 2 |
| Pernow, J | 2 |
| Li, W | 2 |
| Shu, W | 2 |
| Lv, Y | 2 |
| Li, WN | 1 |
| Shu, WQ | 1 |
| Guan, YE | 1 |
| Jia, DL | 1 |
| Ye, HW | 1 |
| Fang, TT | 1 |
| Gu, XY | 1 |
| Wang, Y | 1 |
| Zhu, GY | 1 |
| Yu, Y | 1 |
| Sjöquist, PO | 1 |
| Ichinomiya, T | 1 |
| Cho, S | 2 |
| Higashijima, U | 1 |
| Matsumoto, S | 1 |
| Maekawa, T | 2 |
| Sumikawa, K | 2 |
| Li, Y | 1 |
| Zhu, W | 1 |
| Tao, J | 1 |
| Xin, P | 1 |
| Liu, M | 1 |
| Li, J | 1 |
| Wei, M | 1 |
| Yada, T | 1 |
| Shimokawa, H | 1 |
| Kajiya, F | 1 |
| Hamid, SA | 1 |
| Bower, HS | 1 |
| Baxter, GF | 1 |
| Manintveld, OC | 1 |
| Verdouw, PD | 1 |
| Duncker, DJ | 1 |
| Shibata, I | 1 |
| Yoshitomi, O | 1 |
| Use, T | 1 |
| Ureshino, H | 1 |
| Hara, T | 1 |
| Daniels, S | 1 |
| Duncan, CJ | 1 |
20 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Fasudil on Myocardial Injury in Rats with Myocardial Ischemia and Reperfusion through Rho-ROCK Signal Pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Coronary Artery Disease; Humans; Ischemia; M | 2022 |
The combination approach with Rhokinase inhibition and mechanical circulatory support in myocardial ischemia-reperfusion injury: Rho-kinase inhibition and ventricular unloading.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Coronary Artery Disease; Humans; Male; Myoca | 2022 |
[Fasudil attenuates mitochondrial injury and apoptosis in rat model of myocardial ischemia/reperfusion injury].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Caspase 3; Dynamins; GTP Phosphoh | 2017 |
CaMKII inhibition mitigates ischemia/reperfusion-elicited calpain activation and the damage to membrane skeleton proteins in isolated rat hearts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium-Calmodulin-Dependent P | 2017 |
Protective effects of fasudil hydrochloride post-conditioning on acute myocardial ischemia/reperfusion injury in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; bcl-2-Associated X Protein; Caspa | 2013 |
High‑dose fasudil preconditioning and postconditioning attenuate myocardial ischemia‑reperfusion injury in hypercholesterolemic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Heart; Humans; Hypercholesterolemia; KATP Ch | 2014 |
Rho-kinase activation in leukocytes plays a pivotal role in myocardial ischemia/reperfusion injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cytokines; Enzyme Activation; Inf | 2014 |
The role of arginase and rho kinase in cardioprotection from remote ischemic perconditioning in non-diabetic and diabetic rat in vivo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arginase; Diabetes Mellitus, Experimental; E | 2014 |
Inhibition of Rho-kinase by fasudil restores the cardioprotection of ischemic postconditioninng in hypercholesterolemic rat heart.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Animals; Apoptosis; Cholesterol; Coro | 2014 |
Cardioprotective effects of low-dose combination therapy with rosuvastatin and fasudil in the isolated rat heart.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Calcium Channel Blockers; Cardiot | 2014 |
The protective effect of fasudil pretreatment combined with ischemia postconditioning on myocardial ischemia/reperfusion injury in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cardiotonic Agents; Combined Modality Therap | 2014 |
[Role of autophagy in fasudil-induced Rho kinase inhibition for protection against myocardial ischemia-reperfusion injury in rats].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Autophagy; Caspase 3; Male; Myoca | 2016 |
Inhibition of Rho kinase protects from ischaemia-reperfusion injury via regulation of arginase activity and nitric oxide synthase in type 1 diabetes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arginase; Arginine; Cytoprotection; Diabetes | 2017 |
High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Glucose; Decanoic Acids; Diazoxide; Do | 2012 |
Fasudil protects the heart against ischemia-reperfusion injury by attenuating endoplasmic reticulum stress and modulating SERCA activity: the differential role for PI3K/Akt and JAK2/STAT3 signaling pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cardiotonic Agents; Caspase 12; C | 2012 |
Cardioprotective effect of hydroxyfasudil as a specific Rho-kinase inhibitor, on ischemia-reperfusion injury in canine coronary microvessels in vivo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cardiotonic Agents; Coronary Circulation; Do | 2006 |
Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Androstadienes; Animals; Apoptosis; Cardioton | 2007 |
The RISK of ROCK.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Apoptosis; Cardiotonic Agents; Coron | 2007 |
Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cardiotonic Agents; Disease Models, Animal; | 2008 |
Biochemical pathways of cell damage during the oxygen paradox of the rat heart.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Hypoxia; Creatine Kinase; Heart; In Vit | 1993 |