1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Infarction, Middle Cerebral Artery in 10 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil, a Rho-kinase inhibitor, is a promising neuroprotectant against ischemic stroke; however, its low bioavailability is an obstacle to be overcome." | 7.83 | Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil. ( Asai, T; Fukuta, T; Kikuchi, T; Koide, H; Namba, M; Oku, N; Sato, A; Shimizu, K; Yanagida, Y, 2016) |
| "significantly reduced cerebral infarction." | 5.37 | Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion. ( Hamanaka, J; Hara, H; Hozumi, I; Inuzuka, T; Kawasaki, K; Koumura, A; Shimazawa, M; Tsuruma, K, 2011) |
| "Fasudil, a Rho-kinase inhibitor, is a promising neuroprotectant against ischemic stroke; however, its low bioavailability is an obstacle to be overcome." | 3.83 | Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil. ( Asai, T; Fukuta, T; Kikuchi, T; Koide, H; Namba, M; Oku, N; Sato, A; Shimizu, K; Yanagida, Y, 2016) |
| "In fasudil-treated rats, the internal carotid artery narrowing was ameliorated and L-NAME-induced regional constriction was abolished." | 1.43 | Vessel Dilation Attenuates Endothelial Dysfunction Following Middle Cerebral Artery Occlusion in Hyperglycemic Rats. ( Jiang, Z; Lin, XJ; Mu, ZH; Wang, LP; Wang, YT; Xi, Y; Yang, GY; Zhang, ZJ, 2016) |
| "significantly reduced cerebral infarction." | 1.37 | Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion. ( Hamanaka, J; Hara, H; Hozumi, I; Inuzuka, T; Kawasaki, K; Koumura, A; Shimazawa, M; Tsuruma, K, 2011) |
| "Pharmacological treatment for cerebral ischemia cannot attain sufficiently high concentrations of the drugs in the cerebrospinal fluid (CSF) without precipitating systemic side effects." | 1.31 | Neuroprotection by intrathecal application of liposome-entrapped fasudil in a rat model of ischemia. ( Allen, TM; Ishida, T; Kirchmeier, MJ; Shuaib, A; Takanashi, Y, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukuta, T | 2 |
| Yanagida, Y | 2 |
| Asai, T | 2 |
| Oku, N | 2 |
| Wang, J | 1 |
| Wen, CY | 1 |
| Cui, CC | 1 |
| Xing, Y | 1 |
| Mu, ZH | 1 |
| Jiang, Z | 1 |
| Lin, XJ | 1 |
| Wang, LP | 1 |
| Xi, Y | 1 |
| Zhang, ZJ | 1 |
| Wang, YT | 1 |
| Yang, GY | 1 |
| Sato, A | 1 |
| Namba, M | 1 |
| Kikuchi, T | 1 |
| Koide, H | 1 |
| Shimizu, K | 1 |
| Li, Q | 1 |
| Huang, XJ | 1 |
| He, W | 1 |
| Ding, J | 1 |
| Jia, JT | 1 |
| Fu, G | 1 |
| Wang, HX | 1 |
| Guo, LJ | 1 |
| Koumura, A | 1 |
| Hamanaka, J | 1 |
| Kawasaki, K | 1 |
| Tsuruma, K | 1 |
| Shimazawa, M | 1 |
| Hozumi, I | 1 |
| Inuzuka, T | 1 |
| Hara, H | 1 |
| Liu, K | 1 |
| Li, Z | 1 |
| Wu, T | 1 |
| Ding, S | 1 |
| Rikitake, Y | 1 |
| Kim, HH | 1 |
| Huang, Z | 1 |
| Seto, M | 1 |
| Yano, K | 1 |
| Asano, T | 1 |
| Moskowitz, MA | 2 |
| Liao, JK | 2 |
| Shin, HK | 1 |
| Salomone, S | 1 |
| Potts, EM | 1 |
| Lee, SW | 1 |
| Millican, E | 1 |
| Noma, K | 1 |
| Huang, PL | 1 |
| Boas, DA | 1 |
| Ayata, C | 1 |
| Takanashi, Y | 1 |
| Ishida, T | 1 |
| Kirchmeier, MJ | 1 |
| Shuaib, A | 1 |
| Allen, TM | 1 |
10 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Co-administration of liposomal fasudil and tissue plasminogen activator ameliorated ischemic brain damage in occlusion model rats prepared by photochemically induced thrombosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Drug Combinations; Fibrinoly | 2018 |
Effect of activation of the Ca(2+)-permeable acid-sensing ion channel 1a on focal cerebral ischemia in diabetic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acid Sensing Ion Channels; Animals; Brain; Brain Isch | 2015 |
Vessel Dilation Attenuates Endothelial Dysfunction Following Middle Cerebral Artery Occlusion in Hyperglycemic Rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Cerebral Angiography; Cerebral Arteri | 2016 |
Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Intravenous; Animals; Brain; Brain Is | 2016 |
Neuroprotective potential of fasudil mesylate in brain ischemia-reperfusion injury of rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Cell Survival; Cer | 2009 |
Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Cerebral Infarction; Dose-R | 2011 |
Role of rho kinase in microvascular damage following cerebral ischemia reperfusion in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood-Brain Barrier; Capillary Permeability; | 2011 |
Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Analysis of Variance; Animals; Antihypertensi | 2005 |
Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Brain Ischemia; Cerebrovascul | 2007 |
Neuroprotection by intrathecal application of liposome-entrapped fasudil in a rat model of ischemia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Damage, Chronic; Brain Ischemia; Cereb | 2001 |