1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Idiopathic Parkinson Disease in 8 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil treatment significantly reduced α-Syn aggregation in vitro in a H4 cell culture model as well as in a cell-free assay." | 1.43 | Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease. ( Bähr, M; Becker, S; Dambeck, V; Eckermann, K; Fonseca-Ornelas, L; Koch, JC; Lingor, P; Lopes da Fonseca, T; Outeiro, TF; Tatenhorst, L; Tönges, L; Walle, H; Zweckstetter, M, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ostendorf, F | 1 |
| Metzdorf, J | 1 |
| Gold, R | 1 |
| Haghikia, A | 1 |
| Tönges, L | 3 |
| Lopez-Lopez, A | 1 |
| Labandeira, CM | 1 |
| Labandeira-Garcia, JL | 1 |
| Muñoz, A | 1 |
| Tatenhorst, L | 2 |
| Saal, KA | 1 |
| Koch, JC | 2 |
| Szegő, ÉM | 1 |
| Bähr, M | 2 |
| Lingor, P | 2 |
| Eckermann, K | 1 |
| Dambeck, V | 1 |
| Fonseca-Ornelas, L | 1 |
| Walle, H | 1 |
| Lopes da Fonseca, T | 1 |
| Becker, S | 1 |
| Outeiro, TF | 1 |
| Zweckstetter, M | 1 |
| Li, YH | 1 |
| Yu, JW | 1 |
| Xi, JY | 1 |
| Yu, WB | 1 |
| Liu, JC | 1 |
| Wang, Q | 1 |
| Song, LJ | 1 |
| Feng, L | 1 |
| Yan, YP | 1 |
| Zhang, GX | 1 |
| Xiao, BG | 1 |
| Ma, CG | 1 |
| Nichols, RJ | 2 |
| Dzamko, N | 2 |
| Hutti, JE | 1 |
| Cantley, LC | 1 |
| Deak, M | 2 |
| Moran, J | 1 |
| Bamborough, P | 1 |
| Reith, AD | 2 |
| Alessi, DR | 2 |
| Hentati, F | 1 |
| Prescott, AR | 1 |
| Gillardon, F | 1 |
| Kremmer, E | 1 |
| Froehlich, T | 1 |
| Ueffing, M | 1 |
| Hengerer, B | 1 |
| Gloeckner, CJ | 1 |
8 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Propionic Acid and Fasudil as Treatment Against Rotenone Toxicity in an In Vitro Model of Parkinson's Disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Cell Survival; Cells, Cul | 2020 |
Rho kinase inhibitor fasudil reduces l-DOPA-induced dyskinesia in a rat model of Parkinson's disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Dyskinesia, Drug-Ind | 2020 |
Rho kinase inhibition by fasudil in the striatal 6-hydroxydopamine lesion mouse model of Parkinson disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic Agents; Animals; Apomorphine; Corpus Stria | 2014 |
Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Synuclein; Amides; Animals; Brain; Carrier Prot | 2016 |
Fasudil Enhances Therapeutic Efficacy of Neural Stem Cells in the Mouse Model of MPTP-Induced Parkinson's Disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals | 2017 |
Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Enzyme Activation; Enzyme Inhibitors | 2009 |
Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 14-3-3 Proteins; Amino Acid Sequence; Animals; Blotti | 2010 |
ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amino Acid Sequence; Amino Ac | 2013 |