1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Hypertrophy in 3 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cardiac hypertrophy occurs in as many as 47% of normotensive individuals who chronically use cocaine." | 7.73 | Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy. ( Cuevas, J; Henning, RJ, 2006) |
| "Cardiac hypertrophy occurs in as many as 47% of normotensive individuals who chronically use cocaine." | 3.73 | Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy. ( Cuevas, J; Henning, RJ, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Merkus, D | 1 |
| Tune, JD | 1 |
| Henning, RJ | 1 |
| Cuevas, J | 1 |
| Suzuki, T | 1 |
| Hoshi, H | 1 |
| Sasaki, H | 1 |
| Mitsui, Y | 1 |
3 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Hypertrophy
| Article | Year |
|---|---|
ROCK as a molecular bond connecting coronary microvascular and cardiac remodelling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cardiomyopathies; Endothelin-1; Humans; Hypertrophy; | 2017 |
Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium Channels; Ca | 2006 |
Endothelin-1 stimulates hypertrophy and contractility of neonatal rat cardiac myocytes in a serum-free medium. II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Calcium; Culture Media; En | 1991 |