1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Hypertension, Portal in 2 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Hypertension, Portal: Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results show in secondary biliary cirrhosis that (1) Rho-kinase activation with resultant eNOS down-regulation is substantially involved in the pathogenesis of portal hypertension and (2) Rho-kinase might interact with Akt and subsequently inhibit the binding of Akt to eNOS." | 1.35 | Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis. ( Anegawa, G; Hashizume, M; Kawanaka, H; Kinjo, N; Konishi, K; Maehara, Y; Shimokawa, H; Taketomi, A; Yamaguchi, S; Yoshida, D, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukuda, T | 1 |
| Narahara, Y | 1 |
| Kanazawa, H | 1 |
| Matsushita, Y | 1 |
| Kidokoro, H | 1 |
| Itokawa, N | 1 |
| Kondo, C | 1 |
| Atsukawa, M | 1 |
| Nakatsuka, K | 1 |
| Sakamoto, C | 1 |
| Anegawa, G | 1 |
| Kawanaka, H | 1 |
| Yoshida, D | 1 |
| Konishi, K | 1 |
| Yamaguchi, S | 1 |
| Kinjo, N | 1 |
| Taketomi, A | 1 |
| Hashizume, M | 1 |
| Shimokawa, H | 1 |
| Maehara, Y | 1 |
2 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Hypertension, Portal
| Article | Year |
|---|---|
Effects of fasudil on the portal and systemic hemodynamics of patients with cirrhosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Animals; Arterial Pressure; Female; Hear | 2014 |
Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Aorta; Disease Models, Animal; Hemod | 2008 |