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1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Hyperplasia

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Hyperplasia in 7 studies

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.

Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.

Research Excerpts

ExcerptRelevanceReference
"Fasudil is an inhibitor of protein kinases, including myosin light chain kinase and Rho associated kinase, thereby inhibiting myosin phosphorylation, and it has been clinically used to prevent vasospasm following subarachnoid hemorrage."5.30The kinase inhibitor fasudil (HA-1077) reduces intimal hyperplasia through inhibiting migration and enhancing cell loss of vascular smooth muscle cells. ( Fukui, R; Hoshiga, M; Ii, M; Ishihara, T; Kohbayashi, E; Nakakoji, T; Negoro, N; Nishiguchi, F; Ohsawa, N; Sasaki, Y; Seto, M; Shibata, N, 1999)
"To investigate the effects of Rho-kinase inhibitor--fasudil hydrochloride hydrate on vein graft intimal hyperplasia in vivo."3.75[Experimental study on rho-kinase inhibitor by intravenous injection inhibiting intimal hyperplasia in vein grafts]. ( Guo, M; Ma, L; Pan, J; Yao, S; Yu, X; Zheng, Z, 2009)
"Fasudil treatment had favorable effects on wall mass, inhibiting neointimal (P =."1.32Differential effects of Rho-kinase inhibition on artery wall mass and remodeling. ( Edwards, MS; English, WP; Geary, RL; Li, J; Pearce, JD, 2004)
"Fasudil is an inhibitor of protein kinases, including myosin light chain kinase and Rho associated kinase, thereby inhibiting myosin phosphorylation, and it has been clinically used to prevent vasospasm following subarachnoid hemorrage."1.30The kinase inhibitor fasudil (HA-1077) reduces intimal hyperplasia through inhibiting migration and enhancing cell loss of vascular smooth muscle cells. ( Fukui, R; Hoshiga, M; Ii, M; Ishihara, T; Kohbayashi, E; Nakakoji, T; Negoro, N; Nishiguchi, F; Ohsawa, N; Sasaki, Y; Seto, M; Shibata, N, 1999)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (57.14)18.2507
2000's3 (42.86)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sugimoto, M1
Yamanouchi, D1
Komori, K1
Zheng, Z1
Pan, J1
Ma, L1
Yu, X1
Guo, M1
Yao, S1
Pearce, JD1
Li, J1
Edwards, MS1
English, WP1
Geary, RL1
Migita, K1
Eguchi, K1
Tsukada, T1
Kawabe, Y1
Aoyagi, T1
Nagataki, S1
Seto, M2
Shindo, K1
Ito, K1
Sasaki, Y2
Negoro, N1
Hoshiga, M1
Kohbayashi, E1
Ii, M1
Fukui, R1
Shibata, N1
Nakakoji, T1
Nishiguchi, F1
Ishihara, T1
Ohsawa, N1
Ridefelt, P1
Nygren, P1
Hellman, P1
Larsson, R1
Rastad, J1
Akerström, G1
Gylfe, E1

Reviews

1 review available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Hyperplasia

ArticleYear
Therapeutic approach against intimal hyperplasia of vein grafts through endothelial nitric oxide synthase/nitric oxide (eNOS/NO) and the Rho/Rho-kinase pathway.
    Surgery today, 2009, Volume: 39, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic beta-Antagonists; Animals; Arginine; Cell

2009

Other Studies

6 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Hyperplasia

ArticleYear
[Experimental study on rho-kinase inhibitor by intravenous injection inhibiting intimal hyperplasia in vein grafts].
    Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2009, Volume: 23, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Female; Graft Survival; Hyperplasia; Male; P

2009
Differential effects of Rho-kinase inhibition on artery wall mass and remodeling.
    Journal of vascular surgery, 2004, Volume: 39, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Carotid Arteries; Cells, Cultured; Co

2004
The role of protein kinase in human synovial fibroblast growth.
    Biochemical and biophysical research communications, 1995, May-25, Volume: 210, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arthritis, Rheumatoid; Benzoquinones; Calcium-Calmodu

1995
Selective inhibition of myosin phosphorylation and tension of hyperplastic arteries by the kinase inhibitor HA1077.
    European journal of pharmacology, 1995, Mar-24, Volume: 276, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carotid Arteries; Hyperplasia; In V

1995
The kinase inhibitor fasudil (HA-1077) reduces intimal hyperplasia through inhibiting migration and enhancing cell loss of vascular smooth muscle cells.
    Biochemical and biophysical research communications, 1999, Aug-19, Volume: 262, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Animals; Aorta; Carotid A

1999
Regulation of parathyroid hormone release in normal and pathological parathyroid cells exposed to modulators of protein kinase C.
    Acta endocrinologica, 1992, Volume: 126, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenoma; Animals; Calcium; Cattle; Humans; Hypercalce

1992