1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Heart Failure in 12 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study aims to investigate the protective effects of fasudil, a Rho-kinase inhibitor, on pressure overload induced heart failure in rats." | 7.88 | Fasudil alleviates pressure overload-induced heart failure by activating Nrf2-mediated antioxidant responses. ( Guan, P; Liang, Y; Wang, N, 2018) |
| "To study the expression of Rho/Rho kinase of cardiac muscle in heart failure rats caused by pressure overload and the effects of fasudil on heart failure." | 7.73 | [The expression of Rho/Rho kinase of cardiac muscle in heart failure rats caused by pressure overload and the intervention of fasudil]. ( Qu, C; Zeng, DY; Zhang, M, 2005) |
| "Fasudil was well tolerated; one patient discontinued treatment." | 5.42 | Intravenous fasudil improves in-hospital mortality of patients with right heart failure in severe pulmonary hypertension. ( Ai, ZS; Gomberg-Maitland, M; He, J; Jiang, R; Jiang, X; Jing, ZC; Liu, D; Wang, L; Yuan, P; Zhao, QH, 2015) |
| " This study aims to investigate the protective effects of fasudil, a Rho-kinase inhibitor, on pressure overload induced heart failure in rats." | 3.88 | Fasudil alleviates pressure overload-induced heart failure by activating Nrf2-mediated antioxidant responses. ( Guan, P; Liang, Y; Wang, N, 2018) |
| "To study the expression of Rho/Rho kinase of cardiac muscle in heart failure rats caused by pressure overload and the effects of fasudil on heart failure." | 3.73 | [The expression of Rho/Rho kinase of cardiac muscle in heart failure rats caused by pressure overload and the intervention of fasudil]. ( Qu, C; Zeng, DY; Zhang, M, 2005) |
| "Fasudil was well tolerated; one patient discontinued treatment." | 1.42 | Intravenous fasudil improves in-hospital mortality of patients with right heart failure in severe pulmonary hypertension. ( Ai, ZS; Gomberg-Maitland, M; He, J; Jiang, R; Jiang, X; Jing, ZC; Liu, D; Wang, L; Yuan, P; Zhao, QH, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guan, P | 2 |
| Liang, Y | 1 |
| Wang, N | 2 |
| Yan, X | 1 |
| Jiao, K | 1 |
| Song, X | 1 |
| Jiang, R | 1 |
| Ai, ZS | 1 |
| Jiang, X | 1 |
| Yuan, P | 1 |
| Liu, D | 1 |
| Zhao, QH | 1 |
| He, J | 1 |
| Wang, L | 1 |
| Gomberg-Maitland, M | 1 |
| Jing, ZC | 1 |
| Harris, GS | 1 |
| Lust, RM | 1 |
| Katwa, LC | 1 |
| Wingard, CJ | 1 |
| Zhang, JP | 1 |
| Li, YQ | 1 |
| Chang, YZ | 1 |
| Shi, ZH | 1 |
| Wang, FY | 1 |
| Chu, L | 1 |
| Surma, M | 1 |
| Wei, L | 1 |
| Shi, J | 1 |
| Fukumoto, Y | 1 |
| Haack, KK | 1 |
| Gao, L | 1 |
| Schiller, AM | 1 |
| Curry, PL | 1 |
| Pellegrino, PR | 1 |
| Zucker, IH | 1 |
| Ren, J | 1 |
| Fang, CX | 1 |
| Zhang, M | 1 |
| Qu, C | 1 |
| Zeng, DY | 1 |
| Kishi, T | 1 |
| Hirooka, Y | 1 |
| Masumoto, A | 1 |
| Ito, K | 1 |
| Kimura, Y | 1 |
| Inokuchi, K | 1 |
| Tagawa, T | 1 |
| Shimokawa, H | 1 |
| Takeshita, A | 1 |
| Sunagawa, K | 1 |
| Suzuki, M | 1 |
| Ohte, N | 1 |
| Wang, ZM | 1 |
| Williams, DL | 1 |
| Little, WC | 1 |
| Cheng, CP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Telmisartan (Micardis) For the Prevention of Acute Graft vs. Host Disease Post Allogeneic Hematopoietic Stem Cell Transplantation[NCT02338232] | 32 participants (Actual) | Interventional | 2015-07-07 | Terminated (stopped due to Lack of Accrual) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Heart Failure
| Article | Year |
|---|---|
Rho kinase as a therapeutic target in cardiovascular disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Apoptosis; Cardiovascular Diseases; Coronary | 2011 |
Small guanine nucleotide-binding protein Rho and myocardial function.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Heart Failure; Humans; Intracellular | 2005 |
1 trial available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Heart Failure
| Article | Year |
|---|---|
Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Case-Control Studies; Dose-Response Relationshi | 2005 |
9 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Heart Failure
| Article | Year |
|---|---|
Fasudil alleviates pressure overload-induced heart failure by activating Nrf2-mediated antioxidant responses.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Disease Models, Animal; Heart | 2018 |
Shen'ge powder decreases the cardiomyocyte hypertrophy in chronic heart failure by activating the Rho protein/Rho-associated coiledcoil forming protein kinase signaling pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cardiomegaly; Cell Survival; Dise | 2019 |
Intravenous fasudil improves in-hospital mortality of patients with right heart failure in severe pulmonary hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Intravenous; Adult; Female; Heart Fai | 2015 |
Urotensin II alters vascular reactivity in animals subjected to volume overload.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Aorta, Thoracic; Arteriovenou | 2010 |
Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses isoproterenol-induced heart failure in rats via JNK and ERK1/2 pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; CASP8 and FADD-Like Apoptosis Regulating Pro | 2011 |
[Fasudil(Rho-kinase inhibitor)].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cardiomyopathy, Dilated; Heart Failure; Mice | 2011 |
Central Rho kinase inhibition restores baroreflex sensitivity and angiotensin II type 1 receptor protein imbalance in conscious rabbits with chronic heart failure.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Baroreflex; Brain Stem; Chronic Disease; Con | 2013 |
[The expression of Rho/Rho kinase of cardiac muscle in heart failure rats caused by pressure overload and the intervention of fasudil].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Female; Heart Failure; Myocardium; Protein K | 2005 |
Altered inotropic response of endothelin-1 in cardiomyocytes from rats with isoproterenol-induced cardiomyopathy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Anti-Arrhythmia Agents; Calcium; | 1998 |