1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Glioblastoma in 4 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to explore the anti-tumor effects of Rho/ROCK inhibitor, fasudil, including the possible mechanisms involved in the suppression of the glioblastoma (GBM) cell line progression in vitro and in vivo." | 7.76 | Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo. ( Deng, L; He, Q; Li, G; Li, R; Liu, Q; Zhang, J, 2010) |
| " The aim of this study was to explore the anti-tumor effects of Rho/ROCK inhibitor, fasudil, including the possible mechanisms involved in the suppression of the glioblastoma (GBM) cell line progression in vitro and in vivo." | 3.76 | Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo. ( Deng, L; He, Q; Li, G; Li, R; Liu, Q; Zhang, J, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| He, M | 1 |
| Luo, M | 1 |
| Liu, Q | 2 |
| Chen, J | 1 |
| Li, K | 1 |
| Zheng, M | 1 |
| Weng, Y | 1 |
| Ouyang, L | 1 |
| Liu, A | 1 |
| Deng, L | 1 |
| Li, G | 1 |
| Li, R | 1 |
| He, Q | 1 |
| Zhang, J | 1 |
| Watanabe, I | 1 |
| Horiuchi, T | 1 |
| Fujita, S | 1 |
| Wang, X | 1 |
| Takahashi, A | 1 |
| Ohnishi, K | 1 |
| Matsumoto, H | 1 |
| Suda, K | 1 |
| Ohnishi, T | 1 |
4 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Glioblastoma
| Article | Year |
|---|---|
Combination treatment with fasudil and clioquinol produces synergistic anti-tumor effects in U87 glioblastoma cells by activating apoptosis and autophagy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Autophagy; Blotting, Western; Bra | 2016 |
Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Blotting, Western; Cell Line, Tum | 2010 |
Role of protein kinase C activation in synthesis of complement components C2 and factor B in interferon-gamma-stimulated human fibroblasts, glioblastoma cell line A172 and monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzoquinones; Calcium; Cells, Cultured; Complement C | 1995 |
Bifunctional effects of a protein kinase inhibitor (H-7) on heat-induced p53-dependent WAF1 accumulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzym | 1997 |