1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Glial Cell Tumors in 14 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Resistance to temozolomide (TMZ) is a major clinical challenge in glioma treatment, but the mechanisms of TMZ resistance are poorly understood." | 7.88 | Fasudil increases temozolomide sensitivity and suppresses temozolomide-resistant glioma growth via inhibiting ROCK2/ABCG2. ( Ding, Y; Hu, R; Liu, X; Wang, Q; Yang, M; Zhang, X; Zhou, W, 2018) |
| "The effect of staurosporine, a potent protein kinase C (PKC) inhibitor, on the sensitivity to radiation has been investigated in C6 glioma cells." | 7.68 | Sensitization of C6 glioma cells to radiation by staurosporine, a potent protein kinase C inhibitor. ( Nozawa, Y; Sakai, N; Yamada, H; Zhang, W, 1993) |
| " Imipramine increased the maximum response to 5-HT without altering the EC50 of the dose-response curve." | 5.30 | Chronic imipramine administration amplifies the serotonin2A receptor-induced intracellular Ca2+ mobilization in C6 glioma cells through a calmodulin-dependent pathway. ( Kamei, K; Muneoka, K; Muraoka, S; Takigawa, M, 1998) |
| "Resistance to temozolomide (TMZ) is a major clinical challenge in glioma treatment, but the mechanisms of TMZ resistance are poorly understood." | 3.88 | Fasudil increases temozolomide sensitivity and suppresses temozolomide-resistant glioma growth via inhibiting ROCK2/ABCG2. ( Ding, Y; Hu, R; Liu, X; Wang, Q; Yang, M; Zhang, X; Zhou, W, 2018) |
| "To investigate the possible mechanisms involved in forskolin-induced c-jun mRNA decrease in rat C6 glioma cells, we examined effects of a PKA inhibitor (H-89), a L-type Ca2+ channel blocker (nimodipine), a calmodulin activation inhibitor (calmidazolium chloride) and a Ca2+/calmodulin-dependent protein kinase II inhibitor (KN-62) on forskolin-induced c-jun mRNA down-regulation." | 3.70 | Activation of adenylate cyclase results in down-regulation of c-jun mRNA expression in rat C6 glioma cells. ( Choi, MR; Huh, SO; Kim, YH; Lee, JK; Song, DK; Suh, HW, 1999) |
| "The effect of staurosporine, a potent protein kinase C (PKC) inhibitor, on the sensitivity to radiation has been investigated in C6 glioma cells." | 3.68 | Sensitization of C6 glioma cells to radiation by staurosporine, a potent protein kinase C inhibitor. ( Nozawa, Y; Sakai, N; Yamada, H; Zhang, W, 1993) |
| "Malignant gliomas are characterized by high invasive potential and strong angiogenic ability." | 1.37 | HA1077, a Rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the Rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways. ( Nakabayashi, H; Shimizu, K, 2011) |
| " Imipramine increased the maximum response to 5-HT without altering the EC50 of the dose-response curve." | 1.30 | Chronic imipramine administration amplifies the serotonin2A receptor-induced intracellular Ca2+ mobilization in C6 glioma cells through a calmodulin-dependent pathway. ( Kamei, K; Muneoka, K; Muraoka, S; Takigawa, M, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (28.57) | 18.7374 |
| 1990's | 8 (57.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, X | 1 |
| Liu, X | 1 |
| Zhou, W | 1 |
| Yang, M | 1 |
| Ding, Y | 1 |
| Wang, Q | 1 |
| Hu, R | 1 |
| Nakabayashi, H | 1 |
| Shimizu, K | 1 |
| Kugaya, A | 2 |
| Kagaya, A | 2 |
| Uchitomi, Y | 2 |
| Motohashi, N | 1 |
| Yamawaki, S | 2 |
| Bouillon, M | 1 |
| Audette, M | 1 |
| Fukushima, D | 1 |
| Konishi, M | 1 |
| Maruyama, K | 1 |
| Miyamoto, T | 1 |
| Ishiura, S | 1 |
| Suzuki, K | 1 |
| Zhang, W | 1 |
| Yamada, H | 1 |
| Sakai, N | 1 |
| Nozawa, Y | 1 |
| Zensho, H | 1 |
| Oyamada, T | 1 |
| Tawara, Y | 1 |
| Inagaki, M | 1 |
| Muraoka, S | 1 |
| Kamei, K | 1 |
| Muneoka, K | 1 |
| Takigawa, M | 1 |
| Lee, JK | 1 |
| Choi, MR | 1 |
| Song, DK | 1 |
| Huh, SO | 1 |
| Kim, YH | 1 |
| Suh, HW | 1 |
| Perlman, JH | 1 |
| Gershengorn, MC | 1 |
| Masson, M | 1 |
| Albouz, S | 1 |
| Boutry, JM | 1 |
| Spezzatti, B | 1 |
| Castagna, M | 1 |
| Baumann, N | 1 |
| Shirazi, Y | 1 |
| McMorris, FA | 1 |
| Shin, ML | 1 |
| Press, RD | 1 |
| Misra, A | 1 |
| Gillaspy, G | 1 |
| Samols, D | 1 |
| Goldthwait, DA | 1 |
| Liscovitch, M | 1 |
| Slack, B | 1 |
| Blusztajn, JK | 1 |
| Wurtman, RJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Telmisartan (Micardis) For the Prevention of Acute Graft vs. Host Disease Post Allogeneic Hematopoietic Stem Cell Transplantation[NCT02338232] | 32 participants (Actual) | Interventional | 2015-07-07 | Terminated (stopped due to Lack of Accrual) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Glial Cell Tumors
| Article | Year |
|---|---|
Fasudil increases temozolomide sensitivity and suppresses temozolomide-resistant glioma growth via inhibiting ROCK2/ABCG2.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antineoplastic Combined Chemotherapy Protoco | 2018 |
HA1077, a Rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the Rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Agents; Blotting, Western; Brain Neopl | 2011 |
Inhibition of serotonin-induced Ca2+ mobilization by interleukin-1 beta in rat C6BU-1 glioma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Neoplasms; Calcium; Cell Division; Enz | 1995 |
Transduction of retinoic acid and gamma-interferon signal for intercellular adhesion molecule-1 expression on human tumor cell lines: evidence for the late-acting involvement of protein kinase C inactivation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Adhesion Molecules; Enzyme Activation | 1993 |
Activation of the secretory pathway leads to a decrease in the intracellular amyloidogenic fragments generated from the amyloid protein precursor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amyloid beta-Protein Precursor; Animals; C | 1993 |
Sensitization of C6 glioma cells to radiation by staurosporine, a potent protein kinase C inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Dose-Response Relationship, Radia | 1993 |
Modulation of endothelin-induced intracellular Ca2+ mobilization by interleukin-1 beta and lipopolysaccharide in C6 rat glioma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Endothelin-1; Enzyme Inhibitors; Ge | 1997 |
Chronic imipramine administration amplifies the serotonin2A receptor-induced intracellular Ca2+ mobilization in C6 glioma cells through a calmodulin-dependent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antidepressive Agents, Tricyclic; Antipsycho | 1998 |
Activation of adenylate cyclase results in down-regulation of c-jun mRNA expression in rat C6 glioma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Calcium Channel Blockers; | 1999 |
Thyrotropin-releasing hormone stimulation of phosphoinositide hydrolysis desensitizes. Evidence against mediation by protein kinase C or calcium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cells, Cultured; Chlorides; Dose-Re | 1991 |
Calmodulin antagonist W-7 inhibits lysosomal sphingomyelinase activity in C6 glioma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calmodulin; Desipramine; Glioma; Isoquinolines; Lysos | 1989 |
Arachidonic acid mobilization and phosphoinositide turnover by the terminal complement complex, C5b-9, in rat oligodendrocyte x C6 glioma cell hybrids.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Arachidonic Acid; Arachidonic | 1989 |
Control of the expression of c-sis mRNA in human glioblastoma cells by phorbol ester and transforming growth factor beta 1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Enzyme Activation; Gene Expression Regulation; Glioma | 1989 |
Differential regulation of phosphatidylcholine biosynthesis by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol in NG108-15 neuroblastoma x glioma hybrid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Choline; Chromatography, High Pressure Liqui | 1987 |