1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Glaucoma in 3 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil hydrochloride (Fas), a rho-associated protein kinase inhibitor, proved to be promising for glaucoma management owing to its IOP lowering and antioxidant effects." | 8.12 | Exploring a Novel Fasudil-Phospholipid Complex Formulated as Liposomal Thermosensitive in situ Gel for Glaucoma. ( Ahmed, MF; El-Moslemany, RM; Khalafallah, NM; Khallaf, AM; Morsi, MH, 2022) |
| "Fasudil hydrochloride (Fas), a rho-associated protein kinase inhibitor, proved to be promising for glaucoma management owing to its IOP lowering and antioxidant effects." | 4.12 | Exploring a Novel Fasudil-Phospholipid Complex Formulated as Liposomal Thermosensitive in situ Gel for Glaucoma. ( Ahmed, MF; El-Moslemany, RM; Khalafallah, NM; Khallaf, AM; Morsi, MH, 2022) |
| " Higher baseline IOP and repeated dosing were associated with greater IOP reduction." | 1.32 | Effects of topical H-7 on outflow facility, intraocular pressure, and corneal thickness in monkeys. ( Kaufman, PL; Podos, SM; Tian, B; Wang, RF, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Khallaf, AM | 1 |
| El-Moslemany, RM | 1 |
| Ahmed, MF | 1 |
| Morsi, MH | 1 |
| Khalafallah, NM | 1 |
| Seto, M | 1 |
| Asano, T | 1 |
| Tian, B | 1 |
| Wang, RF | 1 |
| Podos, SM | 1 |
| Kaufman, PL | 1 |
1 review available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Glaucoma
| Article | Year |
|---|---|
[Rho-kinase inhibitors].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Clinical Trials as Topic; Coronary A | 2011 |
2 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Glaucoma
| Article | Year |
|---|---|
Exploring a Novel Fasudil-Phospholipid Complex Formulated as Liposomal Thermosensitive in situ Gel for Glaucoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Gels; Glaucoma; Liposomes; Particle Size; Ph | 2022 |
Effects of topical H-7 on outflow facility, intraocular pressure, and corneal thickness in monkeys.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Topical; Animals; Aqueous Humor; Corn | 2004 |