1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Fibrosarcoma in 4 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated the effects of fasudil, a specific ROCK inhibitor, on BRAK secretion and tumor progression in mesenchymal fibrosarcoma cells (MC57)." | 7.78 | Fasudil suppresses fibrosarcoma growth by stimulating secretion of the chemokine CXCL14/BRAK. ( Hata, R; Ikoma, T; Izukuri, K; Kato, Y; Kubota, E; Lee, MC; Maehata, Y; Miyamoto, C; Ozawa, S, 2012) |
| " We investigated the effects of fasudil, a specific ROCK inhibitor, on BRAK secretion and tumor progression in mesenchymal fibrosarcoma cells (MC57)." | 3.78 | Fasudil suppresses fibrosarcoma growth by stimulating secretion of the chemokine CXCL14/BRAK. ( Hata, R; Ikoma, T; Izukuri, K; Kato, Y; Kubota, E; Lee, MC; Maehata, Y; Miyamoto, C; Ozawa, S, 2012) |
| "Fasudil has been approved for the treatment of cerebral vasospasm and associated cerebral ischemic symptoms." | 1.33 | The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models. ( Alicke, B; Biroc, SL; Dinter, H; Kamata, Y; Li, WW; Ohashi, Y; Okada, T; Pagila, R; Xuan, JA; Ying, H, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miyamoto, C | 1 |
| Maehata, Y | 1 |
| Ozawa, S | 1 |
| Ikoma, T | 1 |
| Kubota, E | 1 |
| Izukuri, K | 1 |
| Kato, Y | 1 |
| Hata, R | 1 |
| Lee, MC | 1 |
| Ying, H | 1 |
| Biroc, SL | 1 |
| Li, WW | 1 |
| Alicke, B | 1 |
| Xuan, JA | 1 |
| Pagila, R | 1 |
| Ohashi, Y | 1 |
| Okada, T | 1 |
| Kamata, Y | 1 |
| Dinter, H | 1 |
| Abend, M | 1 |
| Frombeck, S | 1 |
| Van Beuningen, D | 1 |
| O'Brian, CA | 1 |
| Fan, D | 1 |
| Ward, NE | 1 |
| Seid, C | 1 |
| Fidler, IJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Telmisartan (Micardis) For the Prevention of Acute Graft vs. Host Disease Post Allogeneic Hematopoietic Stem Cell Transplantation[NCT02338232] | 32 participants (Actual) | Interventional | 2015-07-07 | Terminated (stopped due to Lack of Accrual) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Fibrosarcoma
| Article | Year |
|---|---|
Fasudil suppresses fibrosarcoma growth by stimulating secretion of the chemokine CXCL14/BRAK.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cel | 2012 |
The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Breast Neoplasms; Cell Adhesion; Cell Growth | 2006 |
Indications for an active process underlying spontaneous and radiation-induced micronucleation in L929 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aurintricarboxylic Acid; Benzhydryl Compound | 1999 |
Level of protein kinase C activity correlates directly with resistance to adriamycin in murine fibrosarcoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Survival; Doxorubicin; Drug Resistance; | 1989 |