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1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Experimental Leukemia

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Experimental Leukemia in 6 studies

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.

Research Excerpts

ExcerptRelevanceReference
"When ethanolamine was added to cells in conditioned medium to quench PS formation through the exchange of free serine with the ethanolamine moiety of phosphatidylethanolamine (PE), PS labelling was decreased by 33% and the inhibitory TPA effect was significantly decreased."1.27Phorbol ester inhibits phosphatidylserine synthesis in human promyelocytic leukaemia HL60 cells. Possible involvement of free radicals and correlation with phosphorylation of nuclear protein 1b. ( Deli, E; Kiss, Z; Kuo, JF, 1987)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19903 (50.00)18.7374
1990's3 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bertrand, R1
Solary, E1
Jenkins, J1
Pommier, Y1
Miyamoto, K1
Nakamura, S1
Ikeda, K1
Nomura, M1
Wakusawa, S1
Hidaka, H1
Maeyama, K1
Taguchi, Y1
Sakurai, E1
Sasaki, M1
Yamatodani, A1
Watanabe, T1
Juszczak, RJ1
Russell, JH1
Teshima, R1
Suzuki, K1
Ikebuchi, H1
Terao, T1
Kiss, Z1
Deli, E1
Kuo, JF1

Other Studies

6 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Experimental Leukemia

ArticleYear
Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors.
    Experimental cell research, 1993, Volume: 207, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Aphidicolin; Apoptosis; B

1993
Inhibition of the G1/S transition in A65 cells by H-7, a protein kinase C inhibitor.
    Biochemical pharmacology, 1993, Feb-09, Volume: 45, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; G1 Phase; Isoquinolines; Leuk

1993
Effects of inhibitors of protein kinase C on the release and synthesis of histamine in rat basophilic leukemia cells (2H3).
    Japanese journal of pharmacology, 1992, Volume: 58, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Basophils; Calcium; Histamine Rel

1992
Inhibition of cytotoxic T lymphocyte-mediated lysis and cellular proliferation by isoquinoline sulfonamide protein kinase inhibitors. Evidence for the involvement of protein kinase C in lymphocyte function.
    The Journal of biological chemistry, 1989, Jan-15, Volume: 264, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cytotoxicity, Immunologic; Isoquinolines; Le

1989
Possible involvement of phosphorylation of a 36,000-dalton protein of rat basophilic leukemia (RBL-2H3) cell membranes in serotonin release.
    Molecular immunology, 1986, Volume: 23, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basophils; Calcimycin; Cell Membrane; Diglyc

1986
Phorbol ester inhibits phosphatidylserine synthesis in human promyelocytic leukaemia HL60 cells. Possible involvement of free radicals and correlation with phosphorylation of nuclear protein 1b.
    The Biochemical journal, 1987, Dec-15, Volume: 248, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Catalase; Cell Line; Chlorobenzoates; Cycloheximide;

1987