1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Experimental Leukemia in 6 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Excerpt | Relevance | Reference |
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"When ethanolamine was added to cells in conditioned medium to quench PS formation through the exchange of free serine with the ethanolamine moiety of phosphatidylethanolamine (PE), PS labelling was decreased by 33% and the inhibitory TPA effect was significantly decreased." | 1.27 | Phorbol ester inhibits phosphatidylserine synthesis in human promyelocytic leukaemia HL60 cells. Possible involvement of free radicals and correlation with phosphorylation of nuclear protein 1b. ( Deli, E; Kiss, Z; Kuo, JF, 1987) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (50.00) | 18.7374 |
1990's | 3 (50.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Bertrand, R | 1 |
Solary, E | 1 |
Jenkins, J | 1 |
Pommier, Y | 1 |
Miyamoto, K | 1 |
Nakamura, S | 1 |
Ikeda, K | 1 |
Nomura, M | 1 |
Wakusawa, S | 1 |
Hidaka, H | 1 |
Maeyama, K | 1 |
Taguchi, Y | 1 |
Sakurai, E | 1 |
Sasaki, M | 1 |
Yamatodani, A | 1 |
Watanabe, T | 1 |
Juszczak, RJ | 1 |
Russell, JH | 1 |
Teshima, R | 1 |
Suzuki, K | 1 |
Ikebuchi, H | 1 |
Terao, T | 1 |
Kiss, Z | 1 |
Deli, E | 1 |
Kuo, JF | 1 |
6 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Experimental Leukemia
Article | Year |
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Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Aphidicolin; Apoptosis; B | 1993 |
Inhibition of the G1/S transition in A65 cells by H-7, a protein kinase C inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; G1 Phase; Isoquinolines; Leuk | 1993 |
Effects of inhibitors of protein kinase C on the release and synthesis of histamine in rat basophilic leukemia cells (2H3).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Basophils; Calcium; Histamine Rel | 1992 |
Inhibition of cytotoxic T lymphocyte-mediated lysis and cellular proliferation by isoquinoline sulfonamide protein kinase inhibitors. Evidence for the involvement of protein kinase C in lymphocyte function.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cytotoxicity, Immunologic; Isoquinolines; Le | 1989 |
Possible involvement of phosphorylation of a 36,000-dalton protein of rat basophilic leukemia (RBL-2H3) cell membranes in serotonin release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basophils; Calcimycin; Cell Membrane; Diglyc | 1986 |
Phorbol ester inhibits phosphatidylserine synthesis in human promyelocytic leukaemia HL60 cells. Possible involvement of free radicals and correlation with phosphorylation of nuclear protein 1b.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Catalase; Cell Line; Chlorobenzoates; Cycloheximide; | 1987 |