1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Experimental Hepatoma in 11 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dose-response curves defining the TPA-dependent suppression of EROD induction and PKC down-regulation were very similar, as were the initial kinetics of PKC loss and the times of TPA pretreatment required for suppression of EROD induction." | 1.29 | Suppression of cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells by 12-O-tetradecanoylphorbol-13-acetate and inhibitors of protein kinase C. ( Bischer, P; Cantu, AR; Pavone, A; Reiners, JJ; Schöller, A, 1993) |
| "Treatment with cycloheximide (10 micrograms/ml) and H7, a protein kinase C inhibitor (20 microM), inhibited this induction, suggesting that c-myc induction by these agents requires protein synthesis and protein kinase C activation." | 1.28 | Modulation of c-myc gene expression by extracellular stimuli in rat hepatoma cells. ( Kato, K; Morimura, S; Tashiro, F; Ueno, Y, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 10 (90.91) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Reiners, JJ | 1 |
| Schöller, A | 1 |
| Bischer, P | 1 |
| Cantu, AR | 1 |
| Pavone, A | 1 |
| Nagasaka, Y | 2 |
| Kaku, K | 1 |
| Nakamura, K | 1 |
| Kaneko, T | 1 |
| Okubo, M | 1 |
| Larner, J | 1 |
| Arizono, K | 1 |
| Peterson, KL | 1 |
| Brady, FO | 1 |
| Miyamoto, K | 2 |
| Nakamura, S | 1 |
| Nomura, M | 2 |
| Yamamoto, H | 2 |
| Sanae, F | 1 |
| Hidaka, H | 1 |
| Sugiura, N | 1 |
| Warskulat, U | 1 |
| Hammermann, R | 1 |
| Häussinger, D | 1 |
| Butler, AP | 1 |
| Mar, PK | 1 |
| McDonald, FF | 1 |
| Ramsay, RL | 1 |
| Chan, SO | 1 |
| Wong, SS | 1 |
| Yeung, DC | 1 |
| Morimura, S | 1 |
| Kato, K | 1 |
| Tashiro, F | 1 |
| Ueno, Y | 1 |
| Kaneko, Y | 1 |
| Toda, G | 1 |
| Oka, H | 1 |
11 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Experimental Hepatoma
| Article | Year |
|---|---|
Suppression of cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells by 12-O-tetradecanoylphorbol-13-acetate and inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cytochrome P-450 Enzyme System; D | 1993 |
cAMP inhibits the insulin-stimulated mitogen-activated protein kinase pathway in rat hepatoma H4EII cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protei | 1994 |
Mechanisms of aluminum fluoride- and insulin-stimulated p33 mRNA accumulation in rat hepatoma cells: involvement of a G protein and kinase action and demonstration of effects on mRNA turnover.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetyltransferases; Aluminum Compounds; Animals; Cycl | 1993 |
Inhibitors of Ca2+ channels, calmodulin and protein kinases prevent A23187 and other inductions of metallothionein mRNA in EC3 rat hepatoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Chloroadenosine; Animals; Calcimycin; Calcium; Calc | 1993 |
Reverse relationship between malignancy and cyclic AMP-dependent protein kinase activity in Yoshida rat ascites hepatomas.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Cyclic AMP-Dependent Protein | 1993 |
Leukocyte function-associated antigen 1-dependent adhesion of rat hepatoma AH66F cells and inhibition by protein kinase C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibodies, Monoclonal; Cell Adhe | 1997 |
Anisoosmotic regulation of the Nopp140 mRNA in H4IIE rat hepatoma cells and primary hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases | 1999 |
Involvement of protein kinase C in the regulation of ornithine decarboxylase mRNA by phorbol esters in rat hepatoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diglycerides; Down-Regulation; Gene Expressi | 1991 |
Regulation of Ki-ras expression in Reuber H35 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Calcimycin; Calcium; Cell Line; | 1990 |
Modulation of c-myc gene expression by extracellular stimuli in rat hepatoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Concanavalin A; Cyclohex | 1990 |
Effects of teleocidin on the morphology and c-myc expression of hepatoma cells which are not inhibited by protein kinase antagonists.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Butyrates; Cell Division; Diglycerides; Isoq | 1987 |