1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Edema, Pulmonary in 3 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Familial cerebral cavernous malformations (CCMs) in humans result from mutations of CCM2 (malcavernin, OSM, MGC4607), PDCD10 (CCM3), or KRIT1 (CCM1), a Rap1 effector which stabilizes endothelial cell-cell junctions." | 1.36 | Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. ( Awad, IA; Ginsberg, MH; Shenkar, R; Stockton, RA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stockton, RA | 1 |
| Shenkar, R | 1 |
| Awad, IA | 1 |
| Ginsberg, MH | 1 |
| Johnson, A | 1 |
| Phillips, P | 1 |
| Hocking, D | 1 |
| Tsan, MF | 1 |
| Ferro, T | 1 |
| Struhar, D | 1 |
| Harbeck, RJ | 1 |
3 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Edema, Pulmonary
| Article | Year |
|---|---|
Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animal Structures; Animals; Brain Edema; Capillary Pe | 2010 |
Protein kinase inhibitor prevents pulmonary edema in response to H2O2.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Capillary Permeability; Cytoskeleton; Endoth | 1989 |
Inhibition of induced acute lung edema by a novel protein kinase C inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Albumins; Animals; Disease Models, Animal; Enzyme Act | 1987 |