1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Diabetic Angiopathies in 6 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Diabetic Angiopathies: VASCULAR DISEASES that are associated with DIABETES MELLITUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Further, perivascular and myocardial fibrosis, arterial intimal thickening were assessed by histology, and capillary density, nitrotyrosine and ROCK1/2 expressions were evaluated by immunohistochemical staining." | 3.79 | Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation. ( Edgley, AJ; Fujii, Y; Jenkins, MJ; Joshi, M; Kelly, DJ; Pearson, JT; Schwenke, DO; Shirai, M; Sonobe, T; Tsuchimochi, H; Umetani, K; Waddingham, MT; Yoshimoto, M, 2013) |
| "Hyperglycemia and hyperlipidemia directly affected the contractile function of VSMCs." | 1.42 | Diabetes and hyperlipidemia induce dysfunction of VSMCs: contribution of the metabolic inflammation/miRNA pathway. ( Chen, XY; Lan, D; Li, T; Liu, LM; Tian, KL; Wu, Y; Yang, GM; Zhu, Y, 2015) |
| "We conclude that fibroblasts from type 2 diabetes patients are characterized by a hyperactive purinergic loop based either on a higher level of ATP release or on increased P2X7 reactivity." | 1.32 | Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes. ( Adinolfi, E; Baricordi, OR; Chiozzi, P; Di Virgilio, F; Morelli, A; Rizzo, R; Solini, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mishra, RK | 1 |
| Alokam, R | 1 |
| Sriram, D | 1 |
| Yogeeswari, P | 1 |
| Pearson, JT | 1 |
| Jenkins, MJ | 1 |
| Edgley, AJ | 1 |
| Sonobe, T | 1 |
| Joshi, M | 1 |
| Waddingham, MT | 1 |
| Fujii, Y | 1 |
| Schwenke, DO | 1 |
| Tsuchimochi, H | 1 |
| Yoshimoto, M | 1 |
| Umetani, K | 1 |
| Kelly, DJ | 1 |
| Shirai, M | 1 |
| Li, T | 1 |
| Yang, GM | 1 |
| Zhu, Y | 1 |
| Wu, Y | 1 |
| Chen, XY | 1 |
| Lan, D | 1 |
| Tian, KL | 1 |
| Liu, LM | 1 |
| Nuno, DW | 1 |
| Lamping, KG | 1 |
| Arita, R | 1 |
| Solini, A | 1 |
| Chiozzi, P | 1 |
| Morelli, A | 1 |
| Adinolfi, E | 1 |
| Rizzo, R | 1 |
| Baricordi, OR | 1 |
| Di Virgilio, F | 1 |
2 reviews available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Diabetic Angiopathies
| Article | Year |
|---|---|
Potential role of Rho kinase inhibitors in combating diabetes-related complications including diabetic neuropathy--a review.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cardiomyopathies; Diabetes Complicat | 2013 |
[Mechanism of diabetes-induced microvascular damage and therapeutic potential of ROCK inhibition].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diabetic Angiopathies; Diabetic Retinopathy; | 2011 |
4 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Diabetic Angiopathies
| Article | Year |
|---|---|
Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Coronary Angiography; Coronary Circulation; | 2013 |
Diabetes and hyperlipidemia induce dysfunction of VSMCs: contribution of the metabolic inflammation/miRNA pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Connexins; Diabetes Mellitu | 2015 |
The role of rho kinase in sex-dependent vascular dysfunction in type 1 diabetes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diabetes Mellitus, Experimental; Diabetes Me | 2010 |
Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Adenosine Triphosphate; Apopto | 2004 |