1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Diabetes Mellitus, Type 1 in 7 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with fasudil or captopril suppressed not only the inflammation reaction but also the accumulation of the extracellular matrix due to the downregulation of TGF-β1 and MMP-9/TIMP-1, which induces the amelioration of the liver fibrosis with diabetes." | 1.48 | Fasudil alleviates hepatic fibrosis in type 1 diabetic rats: involvement of the inflammation and RhoA/ROCK pathway. ( Chu, L; Huo, M; Ma, ZH; Song, T; Wang, N; Xie, Y; Zhang, JP; Zhang, Y; Zhang, YY, 2018) |
| "The treatment with fasudil after the development of diabetes improved the metabolic abnormalities in OLETF rats, but could not suppress the progression of nephropathy." | 1.34 | A Rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats. ( Higashi, K; Hyodo, N; Imakiire, T; Kikuchi, Y; Kushiyama, T; Miura, S; Oda, T; Suzuki, S; Yamada, M; Yamamoto, K, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, Y | 1 |
| Song, T | 1 |
| Huo, M | 1 |
| Zhang, Y | 1 |
| Zhang, YY | 1 |
| Ma, ZH | 1 |
| Wang, N | 1 |
| Zhang, JP | 1 |
| Chu, L | 1 |
| Waddingham, MT | 1 |
| Edgley, AJ | 1 |
| Astolfo, A | 1 |
| Inagaki, T | 1 |
| Fujii, Y | 1 |
| Du, CK | 1 |
| Zhan, DY | 1 |
| Tsuchimochi, H | 1 |
| Yagi, N | 1 |
| Kelly, DJ | 1 |
| Shirai, M | 1 |
| Pearson, JT | 1 |
| Tratsiakovich, Y | 1 |
| Kiss, A | 1 |
| Gonon, AT | 1 |
| Yang, J | 1 |
| Sjöquist, PO | 1 |
| Pernow, J | 1 |
| Nuno, DW | 1 |
| Lamping, KG | 1 |
| Biswas, PS | 1 |
| Gupta, S | 1 |
| Chang, E | 1 |
| Bhagat, G | 1 |
| Pernis, AB | 1 |
| Kikuchi, Y | 1 |
| Yamada, M | 1 |
| Imakiire, T | 1 |
| Kushiyama, T | 1 |
| Higashi, K | 1 |
| Hyodo, N | 1 |
| Yamamoto, K | 1 |
| Oda, T | 1 |
| Suzuki, S | 1 |
| Miura, S | 1 |
| Lin, G | 1 |
| Craig, GP | 1 |
| Zhang, L | 1 |
| Yuen, VG | 1 |
| Allard, M | 1 |
| McNeill, JH | 1 |
| MacLeod, KM | 1 |
7 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Fasudil alleviates hepatic fibrosis in type 1 diabetic rats: involvement of the inflammation and RhoA/ROCK pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diabetes Mellitus, Experimental; Diabetes Me | 2018 |
Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Diabetes Mellitus, Experimental; Dia | 2015 |
Inhibition of Rho kinase protects from ischaemia-reperfusion injury via regulation of arginase activity and nitric oxide synthase in type 1 diabetes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arginase; Arginine; Cytoprotection; Diabetes | 2017 |
The role of rho kinase in sex-dependent vascular dysfunction in type 1 diabetes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diabetes Mellitus, Experimental; Diabetes Me | 2010 |
Aberrant ROCK activation promotes the development of type I diabetes in NOD mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; CD4-Positive T-Lymphocytes; Diabetes Mellitu | 2011 |
A Rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Glucose; Carrier Proteins; Diabetes Me | 2007 |
Acute inhibition of Rho-kinase improves cardiac contractile function in streptozotocin-diabetic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Animals; Blotting, Western; Cell Surv | 2007 |