1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Diabetes Mellitus, Adult-Onset in 7 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A rat model of type 2 diabetes was established by high fat diet combined with streptozotocin (30 mg/kg, intraperitoneal injection)." | 1.40 | Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, ameliorates hepatic fibrosis in rats with type 2 diabetes. ( Deng, Y; Fang, C; Meng, F; Wang, M; Zhang, L; Zhou, H, 2014) |
| "We conclude that fibroblasts from type 2 diabetes patients are characterized by a hyperactive purinergic loop based either on a higher level of ATP release or on increased P2X7 reactivity." | 1.32 | Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes. ( Adinolfi, E; Baricordi, OR; Chiozzi, P; Di Virgilio, F; Morelli, A; Rizzo, R; Solini, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rothschild, PR | 1 |
| Salah, S | 1 |
| Berdugo, M | 1 |
| Gélizé, E | 1 |
| Delaunay, K | 1 |
| Naud, MC | 1 |
| Klein, C | 1 |
| Moulin, A | 1 |
| Savoldelli, M | 1 |
| Bergin, C | 1 |
| Jeanny, JC | 1 |
| Jonet, L | 1 |
| Arsenijevic, Y | 1 |
| Behar-Cohen, F | 1 |
| Crisanti, P | 1 |
| Matoba, K | 1 |
| Kawanami, D | 1 |
| Okada, R | 1 |
| Tsukamoto, M | 1 |
| Kinoshita, J | 1 |
| Ito, T | 1 |
| Ishizawa, S | 1 |
| Kanazawa, Y | 1 |
| Yokota, T | 1 |
| Murai, N | 1 |
| Matsufuji, S | 1 |
| Takahashi-Fujigasaki, J | 1 |
| Utsunomiya, K | 1 |
| Guo, R | 2 |
| Liu, B | 1 |
| Zhou, S | 1 |
| Zhang, B | 1 |
| Xu, Y | 2 |
| Su, Y | 1 |
| Yan, J | 1 |
| Sun, H | 1 |
| Wu, J | 1 |
| Liu, W | 1 |
| Zhou, H | 1 |
| Fang, C | 1 |
| Zhang, L | 1 |
| Deng, Y | 1 |
| Wang, M | 1 |
| Meng, F | 1 |
| Solini, A | 1 |
| Chiozzi, P | 1 |
| Morelli, A | 1 |
| Adinolfi, E | 1 |
| Rizzo, R | 1 |
| Baricordi, OR | 1 |
| Di Virgilio, F | 1 |
| Leclerc, I | 1 |
| Rutter, GA | 1 |
1 trial available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Fasudil improves short-term echocardiographic parameters of diastolic function in patients with type 2 diabetes with preserved left ventricular ejection fraction: a pilot study.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Diabetes Mellitus, Type 2; Diastole; Echocardio | 2015 |
6 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Animals; Biomarkers; Case-Control Studies; Cyto | 2017 |
Rho-kinase inhibition prevents the progression of diabetic nephropathy by downregulating hypoxia-inducible factor 1α.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Albuminuria; Animals; Diabetes Mellitus, Type 2; Diab | 2013 |
The protective effect of fasudil on the structure and function of cardiac mitochondria from rats with type 2 diabetes induced by streptozotocin with a high-fat diet is mediated by the attenuation of oxidative stress.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biomarkers; Cardiotonic Agents; Diabetes Mel | 2013 |
Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, ameliorates hepatic fibrosis in rats with type 2 diabetes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Connective Tissue Growth Factor; Diabetes Me | 2014 |
Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Adenosine Triphosphate; Apopto | 2004 |
AMP-activated protein kinase: a new beta-cell glucose sensor?: Regulation by amino acids and calcium ions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acids; AMP-Activated Protein Kinases; Animals; | 2004 |