1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Cranial Nerve II Injuries in 7 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil treatment inhibited RGCs apoptosis and reduced RGCs loss demonstrated by the decreased apoptosis-associated proteins expression and the increased fluorogold labeling of RGCs after ONC, respectively." | 5.56 | Fasudil attenuates glial cell-mediated neuroinflammation via ERK1/2 and AKT signaling pathways after optic nerve crush. ( Chen, Q; Cui, L; Hu, B; Huang, H; Huang, W; Jiang, L; Lan, Q; Li, M; Liang, N; Lv, J; Mo, Z; Shen, C; Tang, F; Xu, F; Yan, W; Zeng, S; Zhang, M; Zhong, H, 2020) |
| "Fasudil treatment inhibited RGCs apoptosis and reduced RGCs loss demonstrated by the decreased apoptosis-associated proteins expression and the increased fluorogold labeling of RGCs after ONC, respectively." | 1.56 | Fasudil attenuates glial cell-mediated neuroinflammation via ERK1/2 and AKT signaling pathways after optic nerve crush. ( Chen, Q; Cui, L; Hu, B; Huang, H; Huang, W; Jiang, L; Lan, Q; Li, M; Liang, N; Lv, J; Mo, Z; Shen, C; Tang, F; Xu, F; Yan, W; Zeng, S; Zhang, M; Zhong, H, 2020) |
| " Injection of 10 microM and 100 microM Y-27632 induced extension of the optic axons beyond the crush site, with the latter dosage giving stronger regeneration." | 1.35 | Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats. ( Ichikawa, M; Sagawa, H; Saito, K; Tokita, Y; Watanabe, M; Yoshida, J, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, W | 1 |
| Lan, Q | 1 |
| Jiang, L | 1 |
| Yan, W | 1 |
| Tang, F | 1 |
| Shen, C | 1 |
| Huang, H | 1 |
| Zhong, H | 1 |
| Lv, J | 1 |
| Zeng, S | 1 |
| Li, M | 1 |
| Mo, Z | 1 |
| Hu, B | 1 |
| Liang, N | 1 |
| Chen, Q | 1 |
| Zhang, M | 1 |
| Xu, F | 1 |
| Cui, L | 1 |
| Zhang, J | 1 |
| Wang, W | 1 |
| Wang, H | 1 |
| Liu, J | 1 |
| Zhang, Z | 1 |
| Yu, J | 2 |
| Luan, X | 2 |
| Lan, S | 1 |
| Yan, B | 1 |
| Maier, A | 1 |
| Lin, L | 1 |
| Jing, X | 1 |
| Tura, A | 1 |
| Schuettauf, F | 1 |
| Monnier, PP | 1 |
| Bartz-Schmidt, KU | 1 |
| Henke-Fahle, S | 1 |
| Lingor, P | 1 |
| Teusch, N | 1 |
| Schwarz, K | 1 |
| Mueller, R | 1 |
| Mack, H | 1 |
| Bähr, M | 1 |
| Mueller, BK | 1 |
| Ichikawa, M | 1 |
| Yoshida, J | 1 |
| Saito, K | 1 |
| Sagawa, H | 1 |
| Tokita, Y | 1 |
| Watanabe, M | 1 |
7 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Cranial Nerve II Injuries
| Article | Year |
|---|---|
Fasudil attenuates glial cell-mediated neuroinflammation via ERK1/2 and AKT signaling pathways after optic nerve crush.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cytokines; Extracellular Signal-R | 2020 |
Fasudil protects retinal ganglion cells and promotes axonal regeneration.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Depolymerizing Factors; Animals; Apoptosis; Axo | 2020 |
Fasudil, a Rho-Associated Protein Kinase Inhibitor, Attenuates Traumatic Retinal Nerve Injury in Rabbits.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cells, Cultured; Male; Optic Nerv | 2016 |
Impacts of Rho kinase inhibitor Fasudil on Rho/ROCK signaling pathway in rabbits with optic nerve injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Female; Gene Express | 2015 |
Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Astrocytes; Blotting, Western; Ca | 2009 |
Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Axons; Cell Line; Chondroitin Sulfat | 2007 |
Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Axons; Cats; Cells, Cultured; Dose-R | 2008 |