1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Clinically Isolated CNS Demyelinating Syndrome in 4 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The cuprizone (CPZ)-induced demyelination is widely used to investigate the demyelination/remyelination." | 1.51 | Hydroxyfasudil alleviates demyelination through the inhibition of MOG antibody and microglia activation in cuprizone mouse model. ( Li, YH; Ma, CG; Miao, Q; Song, LJ; Sui, RX; Wang, J; Wang, Q; Xiao, BG; Yu, JZ, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ding, ZB | 1 |
| Han, QX | 1 |
| Wang, Q | 2 |
| Song, LJ | 2 |
| Chu, GG | 1 |
| Guo, MF | 1 |
| Chai, Z | 1 |
| Yu, JZ | 2 |
| Xiao, BG | 2 |
| Li, XY | 1 |
| Ma, CG | 2 |
| Wang, J | 1 |
| Sui, RX | 1 |
| Miao, Q | 1 |
| Li, YH | 1 |
| Baer, AS | 1 |
| Syed, YA | 1 |
| Kang, SU | 1 |
| Mitteregger, D | 1 |
| Vig, R | 1 |
| Ffrench-Constant, C | 1 |
| Franklin, RJ | 1 |
| Altmann, F | 1 |
| Lubec, G | 1 |
| Kotter, MR | 1 |
| Nobbio, L | 1 |
| Sturla, L | 1 |
| Fiorese, F | 1 |
| Usai, C | 1 |
| Basile, G | 1 |
| Moreschi, I | 1 |
| Benvenuto, F | 1 |
| Zocchi, E | 1 |
| De Flora, A | 1 |
| Schenone, A | 1 |
| Bruzzone, S | 1 |
4 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Clinically Isolated CNS Demyelinating Syndrome
| Article | Year |
|---|---|
Fasudil enhances the phagocytosis of myelin debris and the expression of neurotrophic factors in cuprizone-induced demyelinating mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain-Derived Neurotrophic Factor; Cell Diff | 2021 |
Hydroxyfasudil alleviates demyelination through the inhibition of MOG antibody and microglia activation in cuprizone mouse model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Behavior, Animal; Brain; CD4-Positive T-Lymp | 2019 |
Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Carbazoles; Cell Different | 2009 |
P2X7-mediated increased intracellular calcium causes functional derangement in Schwann cells from rats with CMT1A neuropathy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Genetically Modified; Blotting, Wes | 2009 |