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1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Chronic Kidney Diseases

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Chronic Kidney Diseases in 4 studies

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.

Research Excerpts

ExcerptRelevanceReference
" We compared the therapeutic effects of fasudil on the spontaneously hypercholesterolemic (SHC) rat, a model of chronic kidney disease (CKD) with proteinuria, with those of the angiotensin receptor blocker olmesartan (OL) by paying attention to the proteinuria and the macrophage phenotype."3.79Protective effects of Rho kinase inhibitor fasudil on rats with chronic kidney disease. ( Higashi, K; Kumagai, H; Kushiyama, T; Miura, S; Oda, T; Oshima, N; Sakurai, Y; Takechi, H; Uchida, T; Watanabe, A; Yamamoto, K, 2013)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kushiyama, T1
Oda, T1
Yamamoto, K1
Higashi, K1
Watanabe, A1
Takechi, H1
Uchida, T1
Oshima, N1
Sakurai, Y1
Miura, S1
Kumagai, H1
Calò, LA1
Vertolli, U1
Pagnin, E1
Ravarotto, V1
Davis, PA1
Lupia, M1
Naso, E1
Maiolino, G1
Naso, A1
Chu, S1
Mao, X1
Guo, H1
Wang, L1
Li, Z1
Zhang, Y1
Wang, Y1
Wang, H1
Zhang, X1
Peng, W1
Lajdova, I1
Oksa, A1
Chorvat, D1
Topor, P1
Spustova, V1

Other Studies

4 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Chronic Kidney Diseases

ArticleYear
Protective effects of Rho kinase inhibitor fasudil on rats with chronic kidney disease.
    American journal of physiology. Renal physiology, 2013, Jun-01, Volume: 304, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Angiotensin II Type 1 Receptor Blockers; Anim

2013
Increased rho kinase activity in mononuclear cells of dialysis and stage 3-4 chronic kidney disease patients with left ventricular hypertrophy: Cardiovascular risk implications.
    Life sciences, 2016, Mar-01, Volume: 148

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Enzyme Activation; Female; Humans; Hyper

2016
Indoxyl sulfate potentiates endothelial dysfunction via reciprocal role for reactive oxygen species and RhoA/ROCK signaling in 5/6 nephrectomized rats.
    Free radical research, 2017, Volume: 51, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Antioxidants; Cyclic N-Oxides

2017
Purinergic P2X7 receptors participate in disturbed intracellular calcium homeostasis in peripheral blood mononuclear cells of patients with chronic kidney disease.
    Kidney & blood pressure research, 2012, Volume: 35, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adult; Calcium Signaling; Fem

2012