1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Cell Transformation, Neoplastic in 9 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Protein kinase inhibitors block v-Src- and v-Fps-induced 9E3 gene expression with the same dose-response curves seen for PKC agonist-induced 9E3 gene expression." | 1.28 | Evidence that v-src and v-fps gene products use a protein kinase C-mediated pathway to induce expression of a transformation-related gene. ( Berg, KL; Foster, DA; Joseph, C; Qureshi, SA; Spangler, R, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 7 (77.78) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Scholz, G | 1 |
| Martinerie, C | 1 |
| Perbal, B | 1 |
| Hanafusa, H | 1 |
| Wölfle, D | 1 |
| Marquardt, H | 1 |
| Wang, H | 1 |
| Chow, DA | 1 |
| Umans, RS | 1 |
| Kennedy, AR | 2 |
| Su, LN | 1 |
| Toscano, WA | 1 |
| Herbert, JM | 1 |
| Augereau, JM | 1 |
| Gleye, J | 1 |
| Maffrand, JP | 1 |
| Semba, M | 1 |
| Inui, N | 1 |
| Spangler, R | 1 |
| Joseph, C | 1 |
| Qureshi, SA | 1 |
| Berg, KL | 1 |
| Foster, DA | 1 |
| Kischel, T | 1 |
| Harbers, M | 1 |
| Stabel, S | 1 |
| Borowski, P | 1 |
| Müller, K | 1 |
| Hilz, H | 1 |
9 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Transcriptional down regulation of the nov proto-oncogene in fibroblasts transformed by p60v-src.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Cell Nucleus; Cell Transforma | 1996 |
Antioxidants inhibit the enhancement of malignant cell transformation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anticarcinogenic Agents; Antioxidants; Ascor | 1996 |
Protein kinase C expression links natural antibody binding with surveillance of activated and preneoplastic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding Sites, Antibody; Cell Transformation | 1999 |
Effects of activators and inhibitors of protein kinase C on X-ray induced malignant transformation in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antipain; Calcimycin; Cell Transformation, N | 1992 |
Suppression of phorbol ester-enhanced radiation-induced malignancy in vitro by protease inhibitors is independent of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Cell Membrane; Cell Transformatio | 1991 |
Chelerythrine is a potent and specific inhibitor of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibiotics, Antineoplastic; Benz | 1990 |
Effects of activators and inhibitors of protein kinase C on two-stage transformation in BALB/3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line; Cell Transformation, N | 1990 |
Evidence that v-src and v-fps gene products use a protein kinase C-mediated pathway to induce expression of a transformation-related gene.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucl | 1989 |
Tumor promotion and depletion of protein kinase C in epidermal JB6 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Division; Cell Line; Cell Transformation, Neopla | 1989 |